hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02816.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SOS1 | Son of sevenless homolog 1 (SOS-1) | 5 | UniProt NCBI |
| PRAG1 | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | 5 | UniProt NCBI |
| RAPGEF1 | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | 5 | UniProt NCBI |
| PEAK1 | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | 5 | UniProt NCBI |
| CRKL | Crk-like protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9027284 | 3.74224604281e-07 | 0.6 | SOS1 RAPGEF1 CRKL | Erythropoietin activates RAS |
| REAC:R-HSA-9006335 | 3.01907146066e-06 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by Erythropoietin |
| WP:WP313 | 4.88902625878e-06 | 0.6 | SOS1 RAPGEF1 CRKL | Hepatocyte growth factor receptor signaling |
| REAC:R-HSA-187687 | 8.09488316343e-06 | 0.6 | SOS1 RAPGEF1 CRKL | Signalling to ERKs |
| REAC:R-HSA-186763 | 8.09488316343e-06 | 0.6 | SOS1 RAPGEF1 CRKL | Downstream signal transduction |
| WP:WP286 | 1.3807096837e-05 | 0.6 | SOS1 RAPGEF1 CRKL | IL 3 signaling pathway |
| REAC:R-HSA-512988 | 2.84155131715e-05 | 0.6 | SOS1 RAPGEF1 CRKL | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| WP:WP4205 | 3.51369898836e-05 | 0.6 | SOS1 RAPGEF1 CRKL | MET in type 1 papillary renal cell carcinoma |
| KEGG:05211 | 4.05033588721e-05 | 0.6 | SOS1 RAPGEF1 CRKL | Renal cell carcinoma |
| CORUM:2476 | 4.09448956317e-05 | 0.4 | RAPGEF1 CRKL | CRKL-PDGFRA-CRK-RAPGEF1 complex |
| REAC:R-HSA-186797 | 5.3727974474e-05 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by PDGF |
| WP:WP23 | 8.42550380506e-05 | 0.6 | SOS1 RAPGEF1 CRKL | B cell receptor signaling pathway |
| KEGG:04722 | 0.000149400492944 | 0.6 | SOS1 RAPGEF1 CRKL | Neurotrophin signaling pathway |
| REAC:R-HSA-6806834 | 0.00016240432487 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by MET |
| WP:WP2263 | 0.000165566800876 | 0.6 | SOS1 RAPGEF1 CRKL | Androgen receptor network in prostate cancer |
| KEGG:04910 | 0.000299935370843 | 0.6 | SOS1 RAPGEF1 CRKL | Insulin signaling pathway |
| REAC:R-HSA-9012999 | 0.000413380173937 | 0.8 | SOS1 PEAK1 RAPGEF1 PRAG1 | RHO GTPase cycle |
| REAC:R-HSA-170968 | 0.000425287580531 | 0.4 | RAPGEF1 CRKL | Frs2-mediated activation |
| REAC:R-HSA-187037 | 0.000455699137987 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-8875555 | 0.000683310775372 | 0.4 | RAPGEF1 CRKL | MET activates RAP1 and RAC1 |
| REAC:R-HSA-169893 | 0.000683310775372 | 0.4 | RAPGEF1 CRKL | Prolonged ERK activation events |
| REAC:R-HSA-166520 | 0.00074191010701 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by NTRKs |
| KEGG:04510 | 0.0007776530092 | 0.6 | SOS1 RAPGEF1 CRKL | Focal adhesion |
| WP:WP306 | 0.00100625954708 | 0.6 | SOS1 RAPGEF1 CRKL | Focal adhesion |
| REAC:R-HSA-912631 | 0.00259338296865 | 0.4 | RAPGEF1 CRKL | Regulation of signaling by CBL |
| REAC:R-HSA-194315 | 0.00268190833433 | 0.8 | SOS1 PEAK1 RAPGEF1 PRAG1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.00292664866109 | 0.8 | SOS1 PEAK1 RAPGEF1 PRAG1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| WP:WP49 | 0.00309249663983 | 0.4 | SOS1 CRKL | IL 2 signaling pathway |
| WP:WP304 | 0.00744927604553 | 0.4 | SOS1 CRKL | Kit receptor signaling pathway |
| WP:WP585 | 0.00744927604553 | 0.4 | RAPGEF1 CRKL | Interferon type I signaling pathways |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | CRKL SOS1 PEAK1 RAPGEF1 PRAG1 | Signal Transduction |
| REAC:R-HSA-8875878 | 0.00849065158197 | 0.4 | RAPGEF1 CRKL | MET promotes cell motility |
| WP:WP69 | 0.010677250915 | 0.4 | SOS1 CRKL | T cell receptor signaling pathway |
| KEGG:05220 | 0.012157220678 | 0.4 | SOS1 CRKL | Chronic myeloid leukemia |
| KEGG:04012 | 0.0128243509281 | 0.4 | SOS1 CRKL | ErbB signaling pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | SOS1 CRKL | ErbB signaling pathway |
| WP:WP185 | 0.020275205407 | 0.4 | SOS1 RAPGEF1 | Integrin mediated cell adhesion |
| KEGG:04935 | 0.0222006100833 | 0.4 | SOS1 CRKL | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-449147 | 0.0307759989667 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by Interleukins |
| WP:WP3915 | 0.0373080007736 | 0.4 | SOS1 RAPGEF1 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | SOS1 RAPGEF1 CRKL | Signaling by Receptor Tyrosine Kinases |
| WP:WP3929 | 0.0420114386662 | 0.4 | SOS1 CRKL | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | SOS1 CRKL | Chemokine signaling pathway |
| KEGG:05206 | 0.0484667159694 | 0.4 | SOS1 CRKL | MicroRNAs in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PEAK1 | CRKL | 0.997 | 0.064 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () gupta_WMM |
| RAPGEF1 | CRKL | 0.995 | 0.084 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () gupta_WMM |
| PRAG1 | CRKL | 0.995 | 0.082 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () |
| SOS1 | PEAK1 | 0.988 | 0.176 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SOS1 | CRKL | 0.982 | 0.176 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () fraction |
| PRAG1 | PEAK1 | 0.968 | 0.082 | hein_WMM bioplex3_WMM WMM_only |
| SOS1 | PRAG1 | 0.955 | 0.096 | hein_WMM bioplex3_WMM WMM_only |
| PRAG1 | RAPGEF1 | 0.946 | 0.078 | hein_WMM bioplex3_WMM WMM_only |
| SOS1 | RAPGEF1 | 0.946 | 0.088 | hein_WMM bioplex3_WMM WMM_only |
| RAPGEF1 | PEAK1 | 0.905 | 0.056 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes