hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02849.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HYLS1 | Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1) | 5 | UniProt NCBI |
| CEP120 | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005736 | 0.000717679935894 | 1.0 | HYLS1 CEP120 | Short tibia |
| HP:0005772 | 0.00102525705128 | 1.0 | HYLS1 CEP120 | Aplasia/Hypoplasia of the tibia |
| HP:0003826 | 0.00119955074999 | 1.0 | HYLS1 CEP120 | Stillbirth |
| HP:0002876 | 0.00401900764101 | 1.0 | HYLS1 CEP120 | Episodic tachypnea |
| HP:0034241 | 0.00453163616665 | 1.0 | HYLS1 CEP120 | Prenatal death |
| WP:WP4803 | 0.00514595155073 | 1.0 | HYLS1 CEP120 | Ciliopathies |
| HP:0004422 | 0.0054543675128 | 1.0 | HYLS1 CEP120 | Biparietal narrowing |
| HP:0001539 | 0.00733058791663 | 1.0 | HYLS1 CEP120 | Omphalocele |
| HP:0100258 | 0.009230730985 | 1.0 | HYLS1 CEP120 | Preaxial polydactyly |
| HP:0002992 | 0.00999967377346 | 1.0 | HYLS1 CEP120 | Abnormal tibia morphology |
| HP:0002983 | 0.0107993742735 | 1.0 | HYLS1 CEP120 | Micromelia |
| HP:0001162 | 0.0110727761538 | 1.0 | HYLS1 CEP120 | Postaxial hand polydactyly |
| HP:0002789 | 0.011629832485 | 1.0 | HYLS1 CEP120 | Tachypnea |
| HP:0001696 | 0.0146201655512 | 1.0 | HYLS1 CEP120 | Situs inversus totalis |
| HP:0011534 | 0.0152592424465 | 1.0 | HYLS1 CEP120 | Abnormal spatial orientation of the cardiac segments |
| HP:0000657 | 0.0162434892157 | 1.0 | HYLS1 CEP120 | Oculomotor apraxia |
| HP:0002084 | 0.0183042558888 | 1.0 | HYLS1 CEP120 | Encephalocele |
| HP:0011815 | 0.0183042558888 | 1.0 | HYLS1 CEP120 | Cephalocele |
| HP:0001651 | 0.0208639809935 | 1.0 | HYLS1 CEP120 | Dextrocardia |
| HP:0004307 | 0.0212433261025 | 1.0 | HYLS1 CEP120 | Abnormal anatomic location of the heart |
| HP:0001829 | 0.0231913144999 | 1.0 | HYLS1 CEP120 | Foot polydactyly |
| HP:0009136 | 0.0248112206409 | 1.0 | HYLS1 CEP120 | Duplication involving bones of the feet |
| HP:0001305 | 0.026485807158 | 1.0 | HYLS1 CEP120 | Dandy-Walker malformation |
| HP:0100259 | 0.026912997596 | 1.0 | HYLS1 CEP120 | Postaxial polydactyly |
| HP:0034237 | 0.0273436055576 | 1.0 | HYLS1 CEP120 | Open neural tube defect |
| HP:0004362 | 0.0299990213204 | 1.0 | HYLS1 CEP120 | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.0299990213204 | 1.0 | HYLS1 CEP120 | Aganglionic megacolon |
| HP:0025028 | 0.0304535519464 | 1.0 | HYLS1 CEP120 | Abnormal enteric nervous system morphology |
| HP:0012331 | 0.0304535519464 | 1.0 | HYLS1 CEP120 | Abnormal autonomic nervous system morphology |
| HP:0000204 | 0.033730956987 | 1.0 | HYLS1 CEP120 | Cleft upper lip |
| HP:0010950 | 0.0351868219998 | 1.0 | HYLS1 CEP120 | Abnormal fourth ventricle morphology |
| HP:0002198 | 0.0351868219998 | 1.0 | HYLS1 CEP120 | Dilated fourth ventricle |
| HP:0002350 | 0.0376816141579 | 1.0 | HYLS1 CEP120 | Cerebellar cyst |
| HP:0001161 | 0.0418509928331 | 1.0 | HYLS1 CEP120 | Hand polydactyly |
| HP:0000612 | 0.0440177027348 | 1.0 | HYLS1 CEP120 | Iris coloboma |
| HP:0005445 | 0.0490927251387 | 1.0 | HYLS1 CEP120 | Enlarged posterior fossa |
| HP:0006882 | 0.0499436884913 | 0.5 | HYLS1 | Severe hydrocephalus |
| HP:0006379 | 0.0499436884913 | 0.5 | HYLS1 | Proximal tibial hypoplasia |
| HP:0008986 | 0.0499436884913 | 0.5 | HYLS1 | Agenesis of the diaphragm |
| HP:0009752 | 0.0499436884913 | 0.5 | HYLS1 | Cleft in skull base |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HYLS1 | CEP120 | 0.997 | bioplex3_WMM boldt bioplex3_HCT116 gupta () boldt_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| HYLS1 | huMAP3_01323.1 huMAP3_02849.1 huMAP3_11263.1 huMAP3_13878.1 |
| CEP120 | huMAP3_01323.1 huMAP3_02849.1 huMAP3_05934.1 huMAP3_11221.1 huMAP3_11263.1 |