hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02854.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD17 | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | 5 | UniProt NCBI |
| RFC2 | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | 5 | UniProt NCBI |
| ATAD5 | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | 5 | UniProt NCBI |
| RFC3 | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | 5 | UniProt NCBI |
| RFC5 | Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) | 5 | UniProt NCBI |
| DSCC1 | Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) | 5 | UniProt NCBI |
| CDC6 | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | 5 | UniProt NCBI |
| RFC4 | Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) | 5 | UniProt NCBI |
| CHTF8 | Chromosome transmission fidelity protein 8 homolog (hCTF8) | 4 | UniProt NCBI |
| RB1 | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0003689 | 1.70069372575e-18 | 0.7 | RFC5 DSCC1 RFC3 RAD17 CHTF8 RFC4 RFC2 | DNA clamp loader activity |
| CORUM:2804 | 7.93378086195e-18 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | CTF18-cohesion-RFC complex |
| CORUM:3070 | 3.17276751541e-17 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | CTF18-cohesion-RFC-POLH complex |
| CORUM:266 | 3.31256423358e-15 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | RAD17-RFC complex |
| CORUM:270 | 3.31256423358e-15 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | RAD17-RFC complex |
| CORUM:2810 | 3.31256423358e-15 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | RAD17-RFC complex |
| GO:0006275 | 9.35701944215e-15 | 0.9 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 CDC6 RFC4 RFC2 | regulation of DNA replication |
| GO:0031390 | 2.17334574806e-14 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Ctf18 RFC-like complex |
| GO:1900264 | 6.51850689488e-14 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | positive regulation of DNA-directed DNA polymerase activity |
| GO:1900262 | 6.51850689488e-14 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | regulation of DNA-directed DNA polymerase activity |
| CORUM:274 | 1.85344921461e-13 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | 9-1-1-RAD17-RFC complex |
| CORUM:268 | 1.85344921461e-13 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | 9-1-1-RAD17-RFC complex |
| REAC:R-HSA-174411 | 8.59659463252e-13 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Polymerase switching on the C-strand of the telomere |
| GO:0008094 | 4.02303516034e-12 | 0.8 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 RFC4 RFC2 | ATP-dependent activity, acting on DNA |
| REAC:R-HSA-174417 | 5.01232561056e-12 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-176187 | 7.25581792399e-12 | 0.6 | RFC5 RFC3 RAD17 CDC6 RFC4 RFC2 | Activation of ATR in response to replication stress |
| CORUM:2201 | 8.06664600281e-12 | 0.4 | RFC4 RFC5 RFC2 RFC3 | PCNA-RFC2-5 complex |
| CORUM:2200 | 8.06664600281e-12 | 0.4 | RFC4 RFC5 RFC2 RFC3 | RFC2-5 subcomplex |
| GO:0006260 | 1.34757221223e-11 | 0.9 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 CDC6 RFC4 RFC2 | DNA replication |
| CORUM:2202 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | CHTF18-RFC2-5 complex |
| CORUM:2199 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | CHTF18-RFC2-5 complex |
| CORUM:279 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | RFC complex |
| CORUM:277 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | RFC complex |
| CORUM:2797 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | PCNA-CHL12-RFC2-5 complex |
| CORUM:2799 | 4.03199797571e-11 | 0.4 | RFC4 RFC5 RFC2 RFC3 | RFC complex |
| GO:0017116 | 5.77241464357e-11 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | single-stranded DNA helicase activity |
| REAC:R-HSA-180786 | 6.68516806571e-11 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Extension of Telomeres |
| CORUM:2203 | 1.20920199837e-10 | 0.4 | RFC4 RFC5 RFC2 RFC3 | BRD4-RFC complex |
| WP:WP2363 | 4.36119593544e-10 | 0.5 | RFC4 DSCC1 RAD17 CHTF8 RFC3 | Gastric cancer network 2 |
| CORUM:1003 | 5.63923523184e-10 | 0.4 | RFC4 RFC5 RFC2 RFC3 | RC complex (Replication competent complex) |
| REAC:R-HSA-1640170 | 1.43657923965e-09 | 0.9 | RFC5 DSCC1 RFC3 RB1 RAD17 CHTF8 CDC6 RFC4 RFC2 | Cell Cycle |
| GO:0140097 | 1.75958514278e-09 | 0.8 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 RFC4 RFC2 | catalytic activity, acting on DNA |
| GO:0090329 | 2.51405460706e-09 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | regulation of DNA-templated DNA replication |
| REAC:R-HSA-9709570 | 3.02506105837e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 3.528229912e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | HDR through Single Strand Annealing (SSA) |
| WP:WP466 | 3.75979100467e-09 | 0.5 | RFC4 RFC5 CDC6 RFC2 RFC3 | DNA replication |
| REAC:R-HSA-157579 | 4.37414413237e-09 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Telomere Maintenance |
| GO:0051052 | 5.49311040429e-09 | 0.9 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 CDC6 RFC4 RFC2 | regulation of DNA metabolic process |
| REAC:R-HSA-5693616 | 6.25040971168e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9675136 | 7.14128465607e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 7.14128465607e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-5693579 | 9.22692671678e-09 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Homologous DNA Pairing and Strand Exchange |
| CORUM:278 | 1.68385473419e-08 | 0.3 | RFC5 RFC2 RFC4 | RFC core complex |
| REAC:R-HSA-73886 | 1.8848100577e-08 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | Chromosome Maintenance |
| REAC:R-HSA-9675135 | 2.06420282253e-08 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Diseases of DNA repair |
| GO:0003678 | 2.22544333765e-08 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | DNA helicase activity |
| REAC:R-HSA-69091 | 2.66329974158e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Polymerase switching |
| REAC:R-HSA-69109 | 2.66329974158e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Leading Strand Synthesis |
| GO:0005663 | 2.76191861336e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA replication factor C complex |
| GO:2000573 | 3.45566118878e-08 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | positive regulation of DNA biosynthetic process |
| REAC:R-HSA-5656121 | 4.83918061893e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Translesion synthesis by POLI |
| REAC:R-HSA-110312 | 4.83918061893e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Translesion synthesis by REV1 |
| KEGG:03430 | 4.89677977907e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Mismatch repair |
| REAC:R-HSA-5655862 | 6.32607926503e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Translesion synthesis by POLK |
| CORUM:613 | 6.73299894294e-08 | 0.3 | CHTF8 RFC3 DSCC1 | CTF18-CTF8-DCC1-RFC3 complex |
| REAC:R-HSA-69481 | 7.38143751137e-08 | 0.6 | RFC5 RFC3 RAD17 CDC6 RFC4 RFC2 | G2/M Checkpoints |
| REAC:R-HSA-69242 | 7.38143751137e-08 | 0.6 | RFC5 RFC3 RB1 RFC2 CDC6 RFC4 | S Phase |
| WP:WP531 | 9.57185496185e-08 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA mismatch repair |
| REAC:R-HSA-5685942 | 9.62730935343e-08 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-110320 | 1.02956999694e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 1.28653942882e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 1.58873212508e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | PCNA-Dependent Long Patch Base Excision Repair |
| WP:WP5366 | 2.66014337221e-07 | 0.5 | RFC4 ATAD5 RFC5 RFC2 RFC3 | NF1 copy number variation syndrome |
| KEGG:03030 | 3.24352378181e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA replication |
| REAC:R-HSA-110373 | 3.3535578264e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 3.3535578264e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-69473 | 3.95656850838e-07 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 4.44206801108e-07 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 4.70201905217e-07 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Processing of DNA double-strand break ends |
| KEGG:03410 | 6.77976870851e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Base excision repair |
| GO:0140657 | 6.82656894189e-07 | 0.8 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 RFC4 RFC2 | ATP-dependent activity |
| REAC:R-HSA-110314 | 7.25322049724e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Recognition of DNA damage by PCNA-containing replication complex |
| GO:2000278 | 7.51117978355e-07 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | regulation of DNA biosynthetic process |
| REAC:R-HSA-5656169 | 8.32503276128e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 9.51119385451e-07 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA strand elongation |
| WP:WP4753 | 1.32525793849e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Nucleotide excision repair |
| GO:0006259 | 1.32880440525e-06 | 0.9 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 CDC6 RFC4 RFC2 | DNA metabolic process |
| REAC:R-HSA-73933 | 1.38352291517e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Resolution of Abasic Sites (AP sites) |
| GO:0051054 | 1.64903162559e-06 | 0.7 | RFC5 DSCC1 ATAD5 RFC3 RFC2 CHTF8 RFC4 | positive regulation of DNA metabolic process |
| GO:0004386 | 1.8120632292e-06 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | helicase activity |
| REAC:R-HSA-69239 | 1.93781238715e-06 | 0.5 | RFC4 RFC5 CDC6 RFC2 RFC3 | Synthesis of DNA |
| REAC:R-HSA-110313 | 1.94851007479e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-69620 | 2.18250010519e-06 | 0.6 | RFC5 RFC3 RAD17 CDC6 RFC4 RFC2 | Cell Cycle Checkpoints |
| REAC:R-HSA-5693567 | 2.28992459356e-06 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| KEGG:03420 | 2.31932768775e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Nucleotide excision repair |
| GO:0051338 | 2.58224095573e-06 | 0.8 | RFC5 DSCC1 RFC3 RB1 RFC2 CHTF8 CDC6 RFC4 | regulation of transferase activity |
| REAC:R-HSA-5696400 | 2.67060771041e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Dual Incision in GG-NER |
| REAC:R-HSA-5693538 | 2.91191585933e-06 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Homology Directed Repair |
| GO:0140640 | 3.41685566231e-06 | 0.8 | RFC5 DSCC1 ATAD5 RFC3 RAD17 CHTF8 RFC4 RFC2 | catalytic activity, acting on a nucleic acid |
| REAC:R-HSA-73893 | 4.69441276875e-06 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA Damage Bypass |
| REAC:R-HSA-5633007 | 6.64945375209e-06 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Regulation of TP53 Activity |
| GO:0006261 | 7.3710670408e-06 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | DNA-templated DNA replication |
| GO:0071897 | 8.02952519765e-06 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | DNA biosynthetic process |
| REAC:R-HSA-5693532 | 8.076274077e-06 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | DNA Double-Strand Break Repair |
| WP:WP5114 | 1.15733662318e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-69306 | 1.3099295555e-05 | 0.5 | RFC4 RFC5 CDC6 RFC2 RFC3 | DNA Replication |
| REAC:R-HSA-6782210 | 1.55950062043e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.66291944782e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Dual incision in TC-NER |
| WP:WP2446 | 2.24833797869e-05 | 0.4 | RFC5 RB1 RFC3 RFC4 | Retinoblastoma gene in cancer |
| CORUM:2805 | 3.07577115383e-05 | 0.2 | CHTF8 DSCC1 | CTF8-DCC1 subcomplex |
| REAC:R-HSA-73884 | 3.34457823732e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Base Excision Repair |
| REAC:R-HSA-6781827 | 3.52668021108e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 4.77943696984e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| WP:WP4946 | 6.75663156792e-05 | 0.4 | RFC4 RFC5 RFC2 RFC3 | DNA repair pathways full network |
| CORUM:612 | 9.22394575203e-05 | 0.2 | CHTF8 DSCC1 | CTF18-CTF8-DCC1 complex |
| CORUM:2806 | 9.22394575203e-05 | 0.2 | CHTF8 DSCC1 | CTF18-CTF8-DCC1 complex |
| REAC:R-HSA-69278 | 9.47504494937e-05 | 0.6 | RFC5 RFC3 RB1 RFC2 CDC6 RFC4 | Cell Cycle, Mitotic |
| REAC:R-HSA-5696398 | 0.000138239115309 | 0.4 | RFC4 RFC5 RFC2 RFC3 | Nucleotide Excision Repair |
| REAC:R-HSA-73894 | 0.000217508574823 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | DNA Repair |
| GO:0005694 | 0.000297560348568 | 0.9 | RFC5 DSCC1 ATAD5 RFC3 RB1 RAD17 CHTF8 RFC4 RFC2 | chromosome |
| REAC:R-HSA-3700989 | 0.000355451955011 | 0.5 | RFC4 RFC5 RAD17 RFC3 RFC2 | Transcriptional Regulation by TP53 |
| CORUM:435 | 0.000460692494101 | 0.2 | RFC2 RFC4 | BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) |
| GO:0051347 | 0.000461560461759 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | positive regulation of transferase activity |
| GO:0050790 | 0.000594565623817 | 0.8 | RFC5 DSCC1 RFC3 RB1 RFC2 CHTF8 CDC6 RFC4 | regulation of catalytic activity |
| CORUM:434 | 0.000859331699025 | 0.2 | RFC2 RFC4 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| CORUM:433 | 0.00202261196918 | 0.2 | RFC2 RFC4 | BASC complex (BRCA1-associated genome surveillance complex) |
| WP:WP4932 | 0.00313738741595 | 0.3 | RFC5 RFC2 RB1 | 7q11 23 copy number variation syndrome |
| GO:0019219 | 0.00365822298925 | 1.0 | RFC5 DSCC1 ATAD5 RFC3 RB1 RAD17 CHTF8 CDC6 RFC4 RFC2 | regulation of nucleobase-containing compound metabolic process |
| GO:0005657 | 0.00366675599097 | 0.4 | RFC4 RFC5 RFC2 RFC3 | replication fork |
| REAC:R-HSA-212436 | 0.00465548020126 | 0.6 | RFC5 RFC3 RB1 RAD17 RFC4 RFC2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.0087488365386 | 0.6 | RFC5 RFC3 RB1 RAD17 RFC4 RFC2 | RNA Polymerase II Transcription |
| GO:0044093 | 0.0121422690506 | 0.7 | RFC5 DSCC1 RFC3 RB1 RFC2 CHTF8 RFC4 | positive regulation of molecular function |
| GO:0065009 | 0.0144267386478 | 0.8 | RFC5 DSCC1 RFC3 RB1 RFC2 CHTF8 CDC6 RFC4 | regulation of molecular function |
| REAC:R-HSA-74160 | 0.0179061878456 | 0.6 | RFC5 RFC3 RB1 RAD17 RFC4 RFC2 | Gene expression (Transcription) |
| WP:000000 | 0.029871335992 | 1.0 | RFC5 DSCC1 ATAD5 RFC3 RB1 RAD17 CHTF8 CDC6 RFC4 RFC2 | WIKIPATHWAYS |
| WP:000000 | 0.029871335992 | 1.0 | RFC5 DSCC1 ATAD5 RFC3 RB1 RAD17 CHTF8 CDC6 RFC4 RFC2 | WIKIPATHWAYS |
| GO:0043085 | 0.0370674843388 | 0.6 | RFC5 DSCC1 RFC3 RFC2 CHTF8 RFC4 | positive regulation of catalytic activity |
| REAC:R-HSA-1643685 | 0.0385148593027 | 0.6 | RFC5 RFC3 RB1 RAD17 RFC4 RFC2 | Disease |
| GO:0090304 | 0.0476672618515 | 1.0 | RFC5 DSCC1 ATAD5 RFC3 RB1 RAD17 CHTF8 CDC6 RFC4 RFC2 | nucleic acid metabolic process |
| CORUM:5663 | 0.0499436884912 | 0.1 | RB1 | TRIM27-RB1 complex |
| CORUM:1131 | 0.0499436884912 | 0.1 | RFC2 | RFC2-RIalpha complex |
| CORUM:1132 | 0.0499436884912 | 0.1 | RFC4 | RFC2-RIalpha complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RFC5 | RFC4 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| RFC2 | RFC5 | 1.0 | 0.978 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| RFC3 | RFC5 | 1.0 | 0.898 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction treiber_WMM |
| RFC3 | RFC4 | 1.0 | 0.802 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| DSCC1 | CHTF8 | 1.0 | 0.360666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DSCC1 | RFC3 | 1.0 | 0.368 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RFC2 | RFC4 | 0.999 | 0.942 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| DSCC1 | RFC5 | 0.999 | 0.464 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RFC2 | RFC3 | 0.999 | 0.948 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DSCC1 | RFC2 | 0.999 | 0.388 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHTF8 | RFC5 | 0.999 | 0.322 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD17 | RFC4 | 0.999 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| DSCC1 | RFC4 | 0.999 | 0.48 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD17 | RFC5 | 0.999 | 0.216 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CHTF8 | RFC4 | 0.999 | 0.38 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATAD5 | RFC5 | 0.998 | 0.206 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| ATAD5 | RFC4 | 0.996 | 0.258 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| RAD17 | RFC3 | 0.988 | 0.204 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| RFC2 | ATAD5 | 0.986 | 0.29 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RAD17 | RFC2 | 0.985 | 0.222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RFC5 | RB1 | 0.97 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| RFC5 | CDC6 | 0.953 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CHTF8 | RFC2 | 0.893 | 0.344 | bioplex_WMM bioplex3_WMM WMM_only |
| CHTF8 | RFC3 | 0.872 | 0.208 | bioplex_WMM bioplex3_WMM WMM_only |
| RFC3 | CDC6 | 0.737 | 0.134 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ATAD5 | CDC6 | 0.684 | 0.162 | hein_WMM bioplex3_WMM WMM_only |
| ATAD5 | RFC3 | 0.643 | 0.216 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| CHTF8 | RAD17 | 0.631 | 0.23 | bioplex_WMM bioplex3_WMM WMM_only |
| RAD17 | ATAD5 | 0.583 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only |
| DSCC1 | RAD17 | 0.535 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only |
| DSCC1 | ATAD5 | 0.263 | 0.162 | bioplex_WMM bioplex3_WMM WMM_only |
| CHTF8 | ATAD5 | 0.202 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only |
| ATAD5 | RB1 | 0.192 | 0.248 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RFC3 | RB1 | 0.165 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RFC4 | RB1 | 0.144 | 0.128 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CDC6 | RFC4 | 0.122 | 0.262 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| RAD17 | RB1 | 0.095 | 0.114 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CHTF8 | RB1 | 0.061 | 0.094 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| RFC2 | RB1 | 0.058 | 0.096 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CDC6 | RB1 | 0.053 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| DSCC1 | RB1 | 0.043 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| RFC2 | CDC6 | 0.03 | 0.188 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes