hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02905.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GNA13 | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) | 5 | UniProt NCBI |
| PPY | Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)] | 5 | UniProt NCBI |
| GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 5 | UniProt NCBI |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428930 | 2.1588394976e-06 | 0.75 | GNG5 GNA13 GNG10 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-456926 | 4.0993398561e-06 | 0.75 | GNG5 GNA13 GNG10 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-392518 | 5.68914662089e-06 | 0.75 | GNG5 GNA13 GNG10 | Signal amplification |
| WP:WP35 | 2.64882854506e-05 | 0.75 | GNG5 GNA13 GNG10 | G protein signaling pathways |
| REAC:R-HSA-416482 | 5.2908776296e-05 | 0.75 | GNG5 GNA13 GNG10 | G alpha (12/13) signalling events |
| REAC:R-HSA-388396 | 7.14075066073e-05 | 1.0 | GNG5 PPY GNA13 GNG10 | GPCR downstream signalling |
| KEGG:04371 | 7.57238466156e-05 | 0.75 | GNG5 GNA13 GNG10 | Apelin signaling pathway |
| REAC:R-HSA-372790 | 0.000120408247398 | 1.0 | GNG5 PPY GNA13 GNG10 | Signaling by GPCR |
| KEGG:05163 | 0.000394783718861 | 0.75 | GNG5 GNA13 GNG10 | Human cytomegalovirus infection |
| REAC:R-HSA-392851 | 0.00122873738811 | 0.5 | GNG10 GNG5 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-8964315 | 0.00122873738811 | 0.5 | GNG10 GNG5 | G beta:gamma signalling through BTK |
| REAC:R-HSA-418217 | 0.0013924419067 | 0.5 | GNG10 GNG5 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-500657 | 0.0013924419067 | 0.5 | GNG10 GNG5 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-418594 | 0.00146681732031 | 0.75 | PPY GNG10 GNG5 | G alpha (i) signalling events |
| GO:0005834 | 0.00155882617412 | 0.75 | GNG5 GNA13 GNG10 | heterotrimeric G-protein complex |
| REAC:R-HSA-8964616 | 0.00156635412759 | 0.5 | GNG10 GNG5 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-392170 | 0.00194479046925 | 0.5 | GNG10 GNG5 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-392451 | 0.00214930898727 | 0.5 | GNG10 GNG5 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-76002 | 0.00233091981852 | 0.75 | GNG5 GNA13 GNG10 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-202040 | 0.00236402400204 | 0.5 | GNG10 GNG5 | G-protein activation |
| REAC:R-HSA-400042 | 0.00236402400204 | 0.5 | GNG10 GNG5 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-418592 | 0.00236402400204 | 0.5 | GNG10 GNG5 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-451326 | 0.00236402400204 | 0.5 | GNG10 GNG5 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-1296059 | 0.00258893271292 | 0.5 | GNG10 GNG5 | G protein gated Potassium channels |
| REAC:R-HSA-420092 | 0.00258893271292 | 0.5 | GNG10 GNG5 | Glucagon-type ligand receptors |
| REAC:R-HSA-997272 | 0.00258893271292 | 0.5 | GNG10 GNG5 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296041 | 0.00258893271292 | 0.5 | GNG10 GNG5 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-500792 | 0.00273968747995 | 0.75 | PPY GNG10 GNG5 | GPCR ligand binding |
| GO:1905360 | 0.00274053853655 | 0.75 | GNG5 GNA13 GNG10 | GTPase complex |
| REAC:R-HSA-397795 | 0.00359044851421 | 0.5 | GNG10 GNG5 | G-protein beta:gamma signalling |
| REAC:R-HSA-163359 | 0.00359044851421 | 0.5 | GNG10 GNG5 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-1296065 | 0.00359044851421 | 0.5 | GNG10 GNG5 | Inwardly rectifying K+ channels |
| KEGG:05200 | 0.0049271234807 | 0.75 | GNG5 GNA13 GNG10 | Pathways in cancer |
| REAC:R-HSA-977444 | 0.00539805716719 | 0.5 | GNG10 GNG5 | GABA B receptor activation |
| REAC:R-HSA-991365 | 0.00539805716719 | 0.5 | GNG10 GNG5 | Activation of GABAB receptors |
| KEGG:04727 | 0.00551283411821 | 0.5 | GNG10 GNG5 | GABAergic synapse |
| KEGG:05032 | 0.0056793701001 | 0.5 | GNG10 GNG5 | Morphine addiction |
| REAC:R-HSA-432040 | 0.00573491177379 | 0.5 | GNG10 GNG5 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-9660821 | 0.006081926491 | 0.5 | GNG10 GNG5 | ADORA2B mediated anti-inflammatory cytokines production |
| REAC:R-HSA-381676 | 0.006081926491 | 0.5 | GNG10 GNG5 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-418597 | 0.006081926491 | 0.5 | GNG10 GNG5 | G alpha (z) signalling events |
| REAC:R-HSA-6814122 | 0.006081926491 | 0.5 | GNG10 GNG5 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-445717 | 0.00643909852192 | 0.5 | GNG10 GNG5 | Aquaporin-mediated transport |
| REAC:R-HSA-9634597 | 0.00643909852192 | 0.5 | GNG10 GNG5 | GPER1 signaling |
| KEGG:04713 | 0.00654897197861 | 0.5 | GNG10 GNG5 | Circadian entrainment |
| KEGG:04724 | 0.00806816574582 | 0.5 | GNG10 GNG5 | Glutamatergic synapse |
| REAC:R-HSA-977443 | 0.00837722051003 | 0.5 | GNG10 GNG5 | GABA receptor activation |
| KEGG:04726 | 0.00867836513934 | 0.5 | GNG10 GNG5 | Serotonergic synapse |
| KEGG:04725 | 0.00974438450458 | 0.5 | GNG10 GNG5 | Cholinergic synapse |
| GO:0031234 | 0.0131184183431 | 0.75 | GNG5 GNA13 GNG10 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-4086398 | 0.0140623832262 | 0.5 | GNG10 GNG5 | Ca2+ pathway |
| KEGG:04926 | 0.014352694406 | 0.5 | GNG10 GNG5 | Relaxin signaling pathway |
| KEGG:04728 | 0.014619629343 | 0.5 | GNG10 GNG5 | Dopaminergic synapse |
| KEGG:04723 | 0.017422762868 | 0.5 | GNG10 GNG5 | Retrograde endocannabinoid signaling |
| WP:WP3929 | 0.0183400443465 | 0.5 | GNG10 GNG5 | Chemokine signaling pathway |
| REAC:R-HSA-9009391 | 0.019281632575 | 0.5 | GNG10 GNG5 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9664433 | 0.019281632575 | 0.5 | GNG10 GNG5 | Leishmania parasite growth and survival |
| REAC:R-HSA-9662851 | 0.019281632575 | 0.5 | GNG10 GNG5 | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-422356 | 0.0212029570934 | 0.5 | GNG10 GNG5 | Regulation of insulin secretion |
| REAC:R-HSA-1296071 | 0.0218635493976 | 0.5 | GNG10 GNG5 | Potassium Channels |
| REAC:R-HSA-373080 | 0.0232149434748 | 0.5 | GNG10 GNG5 | Class B/2 (Secretin family receptors) |
| KEGG:04062 | 0.0237566589162 | 0.5 | GNG10 GNG5 | Chemokine signaling pathway |
| CORUM:7189 | 0.0249718442456 | 0.25 | GNG10 | GNAS-L-GNB3-GNG10 complex |
| CORUM:7167 | 0.0249718442456 | 0.25 | GNG5 | GNAS-L-GNB3-GNG5 complex |
| REAC:R-HSA-418346 | 0.0260384914588 | 0.5 | GNG10 GNG5 | Platelet homeostasis |
| WP:WP4223 | 0.0270438297073 | 0.5 | GNG10 GNG5 | Ras signaling |
| KEGG:05034 | 0.0272860662684 | 0.5 | GNG10 GNG5 | Alcoholism |
| REAC:R-HSA-111885 | 0.0305753786405 | 0.5 | GNG10 GNG5 | Opioid Signalling |
| REAC:R-HSA-109582 | 0.0327468558633 | 0.75 | GNG5 GNA13 GNG10 | Hemostasis |
| KEGG:05167 | 0.0346546128597 | 0.5 | GNG10 GNG5 | Kaposi sarcoma-associated herpesvirus infection |
| GO:0007186 | 0.0356006384818 | 1.0 | GNG5 PPY GNA13 GNG10 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-390466 | 0.0363250695065 | 0.5 | GNG10 GNG5 | Chaperonin-mediated protein folding |
| KEGG:04014 | 0.0415303647194 | 0.5 | GNG10 GNG5 | Ras signaling pathway |
| REAC:R-HSA-163685 | 0.041644107744 | 0.5 | GNG10 GNG5 | Integration of energy metabolism |
| REAC:R-HSA-418555 | 0.0425656343513 | 0.5 | GNG10 GNG5 | G alpha (s) signalling events |
| REAC:R-HSA-391251 | 0.0425656343513 | 0.5 | GNG10 GNG5 | Protein folding |
| KEGG:05170 | 0.0456663239038 | 0.5 | GNG10 GNG5 | Human immunodeficiency virus 1 infection |
| GO:0019897 | 0.048062454325 | 0.75 | GNG5 GNA13 GNG10 | extrinsic component of plasma membrane |
| CORUM:7078 | 0.049938562206 | 0.25 | GNG10 | GNAI1-GNB3-GNG10 complex |
| CORUM:7059 | 0.049938562206 | 0.25 | GNG5 | GNAI1-GNB3-GNG5 complex |
| CORUM:7168 | 0.049938562206 | 0.25 | GNG5 | GNAS-L-GNB4-GNG5 complex |
| CORUM:7169 | 0.049938562206 | 0.25 | GNG5 | GNAS-L-GNB5-GNG5 complex |
| CORUM:7187 | 0.049938562206 | 0.25 | GNG10 | GNAS-L-GNB1-GNG10 complex |
| CORUM:7188 | 0.049938562206 | 0.25 | GNG10 | GNAS-L-GNB2-GNG10 complex |
| CORUM:7193 | 0.049938562206 | 0.25 | GNG10 | GNAS-L-GNB4-GNG10 complex |
| CORUM:7194 | 0.049938562206 | 0.25 | GNG10 | GNAS-L-GNB5-GNG10 complex |
| CORUM:7165 | 0.049938562206 | 0.25 | GNG5 | GNAS-L-GNB1-GNG5 complex |
| CORUM:7166 | 0.049938562206 | 0.25 | GNG5 | GNAS-L-GNB2-GNG5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GNA13 | GNG10 | 0.997 | 0.238 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GNA13 | GNG5 | 0.997 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| GNG10 | GNG5 | 0.976 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only |
| PPY | GNG10 | 0.97 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GNA13 | PPY | 0.039 | bioplex3_HCT116 WMM_only |
Related Complexes