hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02913.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KCNJ5 | G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) | 5 | UniProt NCBI |
| KCNJ18 | Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) | 5 | UniProt NCBI |
| KCNJ3 | G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04921 | 1.39434656978e-05 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | Oxytocin signaling pathway |
| GO:0005242 | 4.37346186898e-05 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | inward rectifier potassium channel activity |
| HP:0001962 | 8.25108287741e-05 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | Palpitations |
| HP:0003752 | 0.000126523416231 | 0.666666666667 | KCNJ18 KCNJ5 | Episodic flaccid weakness |
| HP:0008153 | 0.000265674927589 | 0.666666666667 | KCNJ18 KCNJ5 | Periodic hypokalemic paresis |
| GO:1990573 | 0.000432059584639 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | potassium ion import across plasma membrane |
| HP:0003768 | 0.000455401167586 | 0.666666666667 | KCNJ18 KCNJ5 | Periodic paralysis |
| KEGG:04929 | 0.000754254484718 | 0.666666666667 | KCNJ3 KCNJ5 | GnRH secretion |
| HP:0010547 | 0.000986522412937 | 0.666666666667 | KCNJ18 KCNJ5 | Muscle flaccidity |
| REAC:R-HSA-997272 | 0.00172341693863 | 0.666666666667 | KCNJ3 KCNJ5 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296059 | 0.00172341693863 | 0.666666666667 | KCNJ3 KCNJ5 | G protein gated Potassium channels |
| REAC:R-HSA-1296041 | 0.00172341693863 | 0.666666666667 | KCNJ3 KCNJ5 | Activation of G protein gated Potassium channels |
| KEGG:05032 | 0.00173372250929 | 0.666666666667 | KCNJ3 KCNJ5 | Morphine addiction |
| GO:0005249 | 0.0018839528051 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | voltage-gated potassium channel activity |
| KEGG:04713 | 0.0019996401701 | 0.666666666667 | KCNJ3 KCNJ5 | Circadian entrainment |
| REAC:R-HSA-1296065 | 0.00239054881557 | 0.666666666667 | KCNJ3 KCNJ5 | Inwardly rectifying K+ channels |
| KEGG:04726 | 0.00265115528622 | 0.666666666667 | KCNJ3 KCNJ5 | Serotonergic synapse |
| KEGG:04725 | 0.00297749484068 | 0.666666666667 | KCNJ18 KCNJ3 | Cholinergic synapse |
| KEGG:04915 | 0.00318234952896 | 0.666666666667 | KCNJ3 KCNJ5 | Estrogen signaling pathway |
| GO:0005267 | 0.00345936027834 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | potassium channel activity |
| REAC:R-HSA-977444 | 0.00359505378021 | 0.666666666667 | KCNJ3 KCNJ5 | GABA B receptor activation |
| REAC:R-HSA-991365 | 0.00359505378021 | 0.666666666667 | KCNJ3 KCNJ5 | Activation of GABAB receptors |
| GO:0015467 | 0.00421361424067 | 0.666666666667 | KCNJ3 KCNJ5 | G-protein activated inward rectifier potassium channel activity |
| KEGG:04728 | 0.00447126662273 | 0.666666666667 | KCNJ3 KCNJ5 | Dopaminergic synapse |
| KEGG:04723 | 0.00533101781525 | 0.666666666667 | KCNJ3 KCNJ5 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-977443 | 0.005581186855 | 0.666666666667 | KCNJ3 KCNJ5 | GABA receptor activation |
| GO:0098659 | 0.00675723888767 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | inorganic cation import across plasma membrane |
| GO:0099587 | 0.00675723888767 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | inorganic ion import across plasma membrane |
| WP:WP536 | 0.00700579973273 | 0.666666666667 | KCNJ3 KCNJ5 | Calcium regulation in cardiac cells |
| HP:0001657 | 0.0075178385046 | 0.666666666667 | KCNJ18 KCNJ5 | Prolonged QT interval |
| GO:0086089 | 0.00842684400117 | 0.666666666667 | KCNJ3 KCNJ5 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
| GO:0022843 | 0.00851239083773 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | voltage-gated monoatomic cation channel activity |
| GO:0099094 | 0.00949377645712 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | ligand-gated monoatomic cation channel activity |
| GO:0015079 | 0.00949377645712 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | potassium ion transmembrane transporter activity |
| HP:0011675 | 0.0107692028076 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | Arrhythmia |
| HP:0031547 | 0.0119478163599 | 0.666666666667 | KCNJ18 KCNJ5 | Abnormal QT interval |
| HP:0030956 | 0.0140478920465 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | Abnormality of cardiovascular system electrophysiology |
| REAC:R-HSA-1296071 | 0.0145828870271 | 0.666666666667 | KCNJ3 KCNJ5 | Potassium Channels |
| GO:0022832 | 0.0150763323228 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | voltage-gated channel activity |
| GO:0005244 | 0.0150763323228 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | voltage-gated monoatomic ion channel activity |
| HP:0002900 | 0.0160978770685 | 0.666666666667 | KCNJ18 KCNJ5 | Hypokalemia |
| GO:0022834 | 0.0180186629002 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | ligand-gated channel activity |
| GO:0015276 | 0.0180186629002 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | ligand-gated monoatomic ion channel activity |
| HP:0001727 | 0.0208637442425 | 0.666666666667 | KCNJ3 KCNJ5 | Thromboembolic stroke |
| HP:0005110 | 0.0208637442425 | 0.666666666667 | KCNJ3 KCNJ5 | Atrial fibrillation |
| GO:0098914 | 0.0210651876021 | 0.666666666667 | KCNJ3 KCNJ5 | membrane repolarization during atrial cardiac muscle cell action potential |
| HP:0001692 | 0.024644630388 | 0.666666666667 | KCNJ3 KCNJ5 | Atrial arrhythmia |
| GO:0071805 | 0.0290879429506 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | potassium ion transmembrane transport |
| GO:1902282 | 0.0294899169624 | 0.666666666667 | KCNJ3 KCNJ5 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| GO:0098739 | 0.0312870733704 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | import across plasma membrane |
| HP:0001678 | 0.0313463863633 | 0.666666666667 | KCNJ18 KCNJ5 | Atrioventricular block |
| HP:0005150 | 0.0359423574679 | 0.666666666667 | KCNJ18 KCNJ5 | Abnormal atrioventricular conduction |
| GO:0006813 | 0.0360123345897 | 1.0 | KCNJ18 KCNJ5 KCNJ3 | potassium ion transport |
| HP:0011042 | 0.037868427304 | 0.666666666667 | KCNJ18 KCNJ5 | Abnormal blood potassium concentration |
| HP:0001907 | 0.037868427304 | 0.666666666667 | KCNJ3 KCNJ5 | Thromboembolism |
| HP:0033678 | 0.0460733968082 | 0.666666666667 | KCNJ3 KCNJ5 | Acute coronary syndrome |
| HP:0001658 | 0.0460733968082 | 0.666666666667 | KCNJ3 KCNJ5 | Myocardial infarction |
| HP:0012591 | 0.0482497424485 | 0.666666666667 | KCNJ18 KCNJ5 | Abnormal urinary electrolyte concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KCNJ5 | KCNJ18 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KCNJ5 | KCNJ3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KCNJ18 | KCNJ3 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| KCNJ5 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |
| KCNJ18 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |
| KCNJ3 | huMAP3_02913.1 huMAP3_06979.1 |