hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02940.1

Complex Portal: CPX-23662

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
PCF11	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	4.80104919782e-12	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	tRNA splicing endonuclease
REAC:R-HSA-6784531	4.92132752099e-07	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	tRNA processing in the nucleus
HP:0006850	5.91234728455e-07	0.5	TSEN15 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0012765	5.91234728455e-07	0.5	TSEN15 TSEN34 TSEN2	Widened cerebellar subarachnoid space
HP:0200049	1.65494737492e-06	0.5	TSEN15 TSEN34 TSEN2	Upper limb hypertonia
HP:0003558	4.87393142655e-06	0.5	TSEN15 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
REAC:R-HSA-72306	5.40567812429e-06	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	tRNA processing
HP:0031162	6.49757420892e-06	0.5	TSEN15 TSEN34 TSEN2	Impaired oropharyngeal swallow response
HP:0000253	1.10619803591e-05	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Progressive microcephaly
HP:0002268	2.0067945866e-05	0.5	TSEN15 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	3.92263544242e-05	0.5	TSEN15 TSEN34 TSEN2	Simple febrile seizure
CORUM:5284	5.12534978153e-05	0.333333333333	TSEN2 CLP1	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0002509	9.70943935954e-05	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Limb hypertonia
HP:0100704	9.98774586679e-05	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Cerebral visual impairment
HP:0006895	0.000160619133799	0.5	TSEN15 TSEN34 TSEN2	Lower limb hypertonia
REAC:R-HSA-8953854	0.000234756919958	0.833333333333	TSEN34 TSEN15 CLP1 TSEN2 PCF11	Metabolism of RNA
HP:0005484	0.00024085827978	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Secondary microcephaly
HP:0200136	0.000268794104831	0.5	TSEN15 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0012704	0.000268794104831	0.5	TSEN15 TSEN34 TSEN2	Widened subarachnoid space
HP:0003201	0.000268794104831	0.5	TSEN15 TSEN34 TSEN2	Rhabdomyolysis
HP:0025190	0.000290543404042	0.5	TSEN15 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	0.000313432690896	0.5	TSEN15 TSEN34 TSEN2	Dysplastic corpus callosum
GO:0006388	0.000316805542726	0.5	TSEN2 CLP1 TSEN34	tRNA splicing, via endonucleolytic cleavage and ligation
HP:0009062	0.000337490834039	0.5	TSEN15 TSEN34 TSEN2	Infantile axial hypotonia
GO:0000394	0.00042234232358	0.5	TSEN2 CLP1 TSEN34	RNA splicing, via endonucleolytic cleavage and ligation
HP:0007598	0.000769715072349	0.5	TSEN15 TSEN34 TSEN2	Bilateral single transverse palmar creases
HP:0002363	0.000880329333254	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Abnormal brainstem morphology
CORUM:1141	0.00133016076778	0.333333333333	PCF11 CLP1	CF IIAm complex (Cleavage factor IIAm complex)
HP:0008936	0.00154050710701	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Axial hypotonia
HP:0012703	0.00205587120443	0.5	TSEN15 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0007362	0.00222409867646	0.5	TSEN15 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0012110	0.00222409867646	0.5	TSEN15 TSEN34 TSEN2	Hypoplasia of the pons
HP:0002365	0.00222409867646	0.5	TSEN15 TSEN34 TSEN2	Hypoplasia of the brainstem
HP:0011471	0.00309448033966	0.5	TSEN15 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
HP:0002536	0.00327620273234	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Abnormal cortical gyration
REAC:R-HSA-77595	0.00440152140132	0.333333333333	PCF11 CLP1	Processing of Intronless Pre-mRNAs
HP:0007361	0.00443283482612	0.5	TSEN15 TSEN34 TSEN2	Abnormal pons morphology
HP:0001266	0.00530249442786	0.5	TSEN15 TSEN34 TSEN2	Choreoathetosis
HP:0002079	0.00693330736043	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Hypoplasia of the corpus callosum
GO:0000213	0.00702301080125	0.333333333333	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0032894	0.00717714082957	0.5	TSEN15 TSEN34 TSEN2	Seizure precipitated by febrile infection
HP:0032892	0.00717714082957	0.5	TSEN15 TSEN34 TSEN2	Infection-related seizure
HP:0002373	0.00717714082957	0.5	TSEN15 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002269	0.00741144488892	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Abnormality of neuronal migration
HP:0002123	0.00857286967155	0.5	TSEN15 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002020	0.00875352451043	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Gastroesophageal reflux
REAC:R-HSA-75067	0.00902151290218	0.333333333333	PCF11 CLP1	Processing of Capped Intronless Pre-mRNA
HP:0002033	0.00922220710687	0.5	TSEN15 TSEN34 TSEN2	Poor suck
HP:0012469	0.0108621519105	0.5	TSEN15 TSEN34 TSEN2	Infantile spasms
HP:0002305	0.014698352718	0.5	TSEN15 TSEN34 TSEN2	Athetosis
HP:0002350	0.0156224342076	0.5	TSEN15 TSEN34 TSEN2	Cerebellar cyst
GO:0000214	0.0210651876021	0.333333333333	TSEN2 CLP1	tRNA-intron endonuclease complex
GO:0000379	0.0210651876021	0.333333333333	TSEN2 TSEN34	tRNA-type intron splice site recognition and cleavage
HP:0032677	0.0215910861519	0.5	TSEN15 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0000340	0.0219826348817	0.5	TSEN15 TSEN34 TSEN2	Sloping forehead
HP:0009127	0.022019943452	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Abnormality of the musculature of the limbs
HP:0011097	0.0244307972482	0.5	TSEN15 TSEN34 TSEN2	Epileptic spasm
HP:0008947	0.0270525934689	0.5	TSEN15 TSEN34 TSEN2	Infantile muscular hypotonia
HP:0033454	0.0284303919892	0.5	TSEN15 TSEN34 TSEN2	Tube feeding
KEGG:03015	0.029291198851	0.333333333333	PCF11 CLP1	mRNA surveillance pathway
HP:0000954	0.0293741864658	0.5	TSEN15 TSEN34 TSEN2	Single transverse palmar crease
HP:0010576	0.0308282983803	0.5	TSEN15 TSEN34 TSEN2	Intracranial cystic lesion
HP:0030724	0.0318236267042	0.5	TSEN15 TSEN34 TSEN2	Central nervous system cyst
HP:0011344	0.0328399365009	0.5	TSEN15 TSEN34 TSEN2	Severe global developmental delay
REAC:R-HSA-72187	0.0379731829042	0.333333333333	PCF11 CLP1	mRNA 3'-end processing
HP:0002104	0.0411521790966	0.5	TSEN15 TSEN34 TSEN2	Apnea
HP:0002072	0.0435813356909	0.5	TSEN15 TSEN34 TSEN2	Chorea
HP:0032794	0.0467483115964	0.5	TSEN15 TSEN34 TSEN2	Myoclonic seizure
HP:0002119	0.0474661990519	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Ventriculomegaly
HP:0007370	0.0494403483522	0.666666666667	TSEN34 TSEN15 CLP1 TSEN2	Aplasia/Hypoplasia of the corpus callosum
REAC:R-HSA-73856	0.0498675109087	0.333333333333	PCF11 CLP1	RNA Polymerase II Transcription Termination

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TSEN15	TSEN34	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN2	0.999	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN15	CLP1	0.998	0.07		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN34	0.998	0.12		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CLP1	PCF11	0.997	0.27	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction
PHLDA2	CLP1	0.952	0.062		hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	PCF11	0.796	0.05		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN34	0.215	0.056		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN2	0.209	0.09		bioplex3_WMM WMM_only
PHLDA2	PCF11	0.135	0.058		bioplex3_WMM WMM_only
PHLDA2	TSEN2	0.122	0.062		bioplex3_WMM WMM_only
TSEN15	PHLDA2	0.086	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN34	0.063	0.064		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
PCF11	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_12111.1 huMAP3_13730.1 huMAP3_14483.1 huMAP3_14586.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02940.1

Complex Portal: CPX-23662