hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02945.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAB14 | Ras-related protein Rab-14 | 5 | UniProt NCBI |
| RAB1A | Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein) | 5 | UniProt NCBI |
| RAB7A | Ras-related protein Rab-7a (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAB5C | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 5.35706921361e-08 | 1.0 | RAB7A RAB14 RAB5C RAB1A | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 1.59771447866e-07 | 1.0 | RAB7A RAB14 RAB5C RAB1A | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 5.14641931672e-07 | 1.0 | RAB7A RAB14 RAB5C RAB1A | Rab regulation of trafficking |
| KEGG:04148 | 0.000105799991328 | 0.75 | RAB14 RAB5C RAB7A | Efferocytosis |
| REAC:R-HSA-199991 | 0.000426838992032 | 1.0 | RAB7A RAB14 RAB5C RAB1A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000530772712934 | 1.0 | RAB7A RAB14 RAB5C RAB1A | Vesicle-mediated transport |
| GO:0003924 | 0.00366770658506 | 1.0 | RAB7A RAB14 RAB5C RAB1A | GTPase activity |
| REAC:R-HSA-8854214 | 0.007571530532 | 0.5 | RAB7A RAB5C | TBC/RABGAPs |
| KEGG:05146 | 0.00909742323246 | 0.5 | RAB7A RAB5C | Amoebiasis |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | RAB7A RAB14 RAB5C RAB1A | Post-translational protein modification |
| KEGG:04137 | 0.0118173906169 | 0.5 | RAB7A RAB5C | Mitophagy - animal |
| GO:0019003 | 0.0152210712647 | 0.75 | RAB14 RAB5C RAB7A | GDP binding |
| REAC:R-HSA-6798695 | 0.0179349264259 | 0.75 | RAB14 RAB5C RAB7A | Neutrophil degranulation |
| GO:0017111 | 0.0191409054275 | 1.0 | RAB7A RAB14 RAB5C RAB1A | ribonucleoside triphosphate phosphatase activity |
| KEGG:04145 | 0.0214296747035 | 0.5 | RAB7A RAB5C | Phagosome |
| KEGG:05152 | 0.02620193588 | 0.5 | RAB7A RAB5C | Tuberculosis |
| KEGG:04140 | 0.0298999303213 | 0.5 | RAB1A RAB7A | Autophagy - animal |
| GO:0016818 | 0.0305291540849 | 1.0 | RAB7A RAB14 RAB5C RAB1A | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.0305291540849 | 1.0 | RAB7A RAB14 RAB5C RAB1A | hydrolase activity, acting on acid anhydrides |
| GO:0016462 | 0.0305291540849 | 1.0 | RAB7A RAB14 RAB5C RAB1A | pyrophosphatase activity |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | RAB7A RAB14 RAB5C RAB1A | Metabolism of proteins |
| GO:0006897 | 0.0467824894143 | 1.0 | RAB7A RAB14 RAB5C RAB1A | endocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RAB14 | RAB7A | 0.999 | 0.514 | hein_WMM bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM treiber_WMM WMM_only |
| RAB1A | RAB7A | 0.996 | 0.784 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB14 | RAB1A | 0.993 | 0.776 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| RAB5C | RAB14 | 0.99 | 0.828 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| RAB5C | RAB7A | 0.978 | 0.602 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB5C | RAB1A | 0.971 | 0.834 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Related Complexes