hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02949.1
Complex Portal: CPX-12587
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | 5 | UniProt NCBI |
| LCTL | Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein) | 4 | UniProt NCBI |
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | 5 | UniProt NCBI |
| SEMA4A | Semaphorin-4A (Semaphorin-B) (Sema B) | 5 | UniProt NCBI |
| LEMD3 | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3876 | 0.000264396631677 | 0.4 | SMAD9 SMAD5 | BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation |
| WP:WP2895 | 0.00123199381981 | 0.4 | SMAD9 SMAD5 | Differentiation of white and brown adipocyte |
| WP:WP4331 | 0.00290547066497 | 0.4 | SMAD9 SMAD5 | Neovascularisation processes |
| REAC:R-HSA-201451 | 0.00454605723789 | 0.4 | SMAD9 SMAD5 | Signaling by BMP |
| WP:WP560 | 0.00528162918062 | 0.4 | SMAD9 SMAD5 | TGF beta receptor signaling |
| WP:WP4816 | 0.00578890329638 | 0.4 | SMAD9 SMAD5 | TGF beta receptor signaling in skeletal dysplasias |
| WP:WP5352 | 0.00631928190743 | 0.4 | SMAD9 SMAD5 | 10q11 21q11 23 copy number variation syndrome |
| WP:WP5205 | 0.0132783799217 | 0.4 | SMAD9 SMAD5 | Clock controlled autophagy in bone metabolism |
| WP:WP5353 | 0.015731077008 | 0.4 | SMAD9 SMAD5 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04350 | 0.0168082536599 | 0.4 | SMAD9 SMAD5 | TGF-beta signaling pathway |
| WP:WP3931 | 0.0287269200827 | 0.4 | SMAD9 SMAD5 | Embryonic stem cell pluripotency pathways |
| WP:WP4787 | 0.0298851974032 | 0.4 | SMAD9 SMAD5 | Osteoblast differentiation and related diseases |
| KEGG:04550 | 0.0319348346673 | 0.4 | SMAD9 SMAD5 | Signaling pathways regulating pluripotency of stem cells |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMAD9 | LEMD3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SEMA4A | LEMD3 | 0.97 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SMAD5 | LEMD3 | 0.967 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LCTL | LEMD3 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes