hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02950.1
Complex Portal: CPX-21738
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | 5 | UniProt NCBI |
| IMMT | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | 5 | UniProt NCBI |
| MTX3 | Metaxin-3 | 4 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | 5 | UniProt NCBI |
| APOOL | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | 5 | UniProt NCBI |
| CRACR2B | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | 5 | UniProt NCBI |
| CARD19 | Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0001401 | 3.98884551806e-10 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | SAM complex |
| GO:0140275 | 3.98884551806e-10 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | MIB complex |
| CORUM:6249 | 7.0490440398e-10 | 0.5 | MTX2 APOOL SAMM50 IMMT | MIB complex |
| GO:0005742 | 7.79777844544e-09 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial outer membrane translocase complex |
| GO:0098799 | 1.02328314981e-08 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | outer mitochondrial membrane protein complex |
| REAC:R-HSA-8949613 | 2.13574543247e-07 | 0.5 | MTX2 APOOL SAMM50 IMMT | Cristae formation |
| GO:0007007 | 3.29814637009e-07 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | inner mitochondrial membrane organization |
| GO:0007006 | 1.63146572742e-05 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial membrane organization |
| REAC:R-HSA-1592230 | 1.63471640191e-05 | 0.5 | MTX2 APOOL SAMM50 IMMT | Mitochondrial biogenesis |
| GO:0098800 | 0.000262787112498 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | inner mitochondrial membrane protein complex |
| CORUM:6255 | 0.000358447219737 | 0.25 | APOOL IMMT | MICOS complex |
| GO:0005741 | 0.000378074212138 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial outer membrane |
| HPA:0241103 | 0.000388731962222 | 0.75 | MTX2 TRAK1 IMMT APOOL CRACR2B SAMM50 | heart muscle; cardiomyocytes[High] |
| GO:0007005 | 0.000444120223896 | 0.75 | MTX3 IMMT MTX2 APOOL TRAK1 SAMM50 | mitochondrion organization |
| GO:0031968 | 0.000614345450659 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | organelle outer membrane |
| GO:0019867 | 0.00063230522663 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | outer membrane |
| KEGG:04137 | 0.000791024458035 | 0.375 | MTX3 SAMM50 MTX2 | Mitophagy - animal |
| REAC:R-HSA-1852241 | 0.0017212773113 | 0.5 | MTX2 APOOL SAMM50 IMMT | Organelle biogenesis and maintenance |
| HPA:0360053 | 0.00225866712274 | 0.75 | MTX3 CRACR2B IMMT MTX2 TRAK1 SAMM50 | parathyroid gland; glandular cells[High] |
| GO:0042407 | 0.00300428100757 | 0.375 | APOOL SAMM50 IMMT | cristae formation |
| HPA:0360052 | 0.00342134563787 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | parathyroid gland; glandular cells[>=Medium] |
| HPA:0030071 | 0.00574478196768 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | appendix; lymphoid tissue[>=Low] |
| GO:0098798 | 0.00726772903132 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial protein-containing complex |
| HPA:0430052 | 0.0130722497279 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | seminal vesicle; glandular cells[>=Medium] |
| GO:0005739 | 0.0144653996187 | 0.875 | CARD19 MTX3 IMMT MTX2 APOOL TRAK1 SAMM50 | mitochondrion |
| HPA:0570732 | 0.0147630653452 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | testis; Leydig cells[>=Medium] |
| HPA:0500000 | 0.0148623646522 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | soft tissue 1 |
| HPA:0090161 | 0.0197252977611 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | cerebellum; Purkinje cells[>=Low] |
| HPA:0351181 | 0.0231865452418 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | pancreas; pancreatic endocrine cells[>=Low] |
| HPA:0290401 | 0.0249315740551 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | liver; hepatocytes[>=Low] |
| HPA:0360000 | 0.0324185979528 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | parathyroid gland |
| HPA:0360051 | 0.0324185979528 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | parathyroid gland; glandular cells[>=Low] |
| GO:0005743 | 0.0359079131582 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | mitochondrial inner membrane |
| HPA:0130052 | 0.0366305862407 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | colon; glandular cells[>=Medium] |
| HPA:0610832 | 0.0370714569997 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | urinary bladder; urothelial cells[>=Medium] |
| HPA:0020052 | 0.0372379764948 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | adrenal gland; glandular cells[>=Medium] |
| HPA:0480052 | 0.0394045873072 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | small intestine; glandular cells[>=Medium] |
| HPA:0400052 | 0.042050413614 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | rectum; glandular cells[>=Medium] |
| HPA:0150052 | 0.0422363400125 | 1.0 | CARD19 MTX3 CRACR2B IMMT MTX2 APOOL TRAK1 SAMM50 | duodenum; glandular cells[>=Medium] |
| HPA:0090162 | 0.0473766132884 | 0.875 | CARD19 MTX3 IMMT MTX2 APOOL TRAK1 SAMM50 | cerebellum; Purkinje cells[>=Medium] |
| GO:0019866 | 0.0475951624611 | 0.625 | MTX3 MTX2 APOOL SAMM50 IMMT | organelle inner membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SAMM50 | MTX2 | 1.0 | 0.958 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| IMMT | MTX2 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM | ||
| MTX2 | CARD19 | 1.0 | 0.27 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| TRAK1 | CARD19 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX3 | MTX2 | 0.998 | 0.32 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| IMMT | CARD19 | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| SAMM50 | CARD19 | 0.998 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SAMM50 | IMMT | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| TRAK1 | SAMM50 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTX3 | CARD19 | 0.995 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TRAK1 | IMMT | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAMM50 | MTX3 | 0.985 | 0.404 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IMMT | MTX3 | 0.983 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| TRAK1 | MTX2 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| APOOL | CARD19 | 0.978 | 0.196 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CRACR2B | CARD19 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MTX3 | APOOL | 0.95 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SAMM50 | APOOL | 0.948 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MTX2 | APOOL | 0.948 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IMMT | APOOL | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| TRAK1 | MTX3 | 0.855 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TRAK1 | APOOL | 0.41 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IMMT | CRACR2B | 0.033 | bioplex3_HEK293 bioplex () |
Related Complexes