hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02953.1
Complex Portal: CPX-20387
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) | 2 | UniProt NCBI |
| DCAF16 | DDB1- and CUL4-associated factor 16 | 4 | UniProt NCBI |
| CRBN | Protein cereblon | 5 | UniProt NCBI |
| RBX1 | E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)] | 5 | UniProt NCBI |
| CUL4A | Cullin-4A (CUL-4A) | 5 | UniProt NCBI |
| CUL4B | Cullin-4B (CUL-4B) | 5 | UniProt NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | 5 | UniProt NCBI |
| DDA1 | DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0080008 | 1.18122777854e-13 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | Cul4-RING E3 ubiquitin ligase complex |
| GO:0031461 | 9.66926634264e-09 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | cullin-RING ubiquitin ligase complex |
| CORUM:6875 | 3.92798604902e-08 | 0.375 | CUL4A CRBN RBX1 | CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase |
| CORUM:1162 | 9.81744484776e-08 | 0.375 | CUL4A RBX1 CUL4B | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) |
| GO:0000151 | 3.2902832111e-07 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | ubiquitin ligase complex |
| GO:0031464 | 1.8396911621e-06 | 0.5 | CUL4A CUL4B CRBN RBX1 | Cul4A-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 9.49349875985e-06 | 0.625 | CUL4A CUL4B DCAF16 DDA1 RBX1 | Neddylation |
| CORUM:2722 | 7.17483486175e-05 | 0.25 | CUL4A RBX1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:391 | 7.17483486175e-05 | 0.25 | CUL4A RBX1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:224 | 7.17483486175e-05 | 0.25 | RBX1 CUL4B | CAND1-CUL4B-RBX1 complex |
| CORUM:223 | 7.17483486175e-05 | 0.25 | CUL4A RBX1 | CAND1-CUL4A-RBX1 complex |
| REAC:R-HSA-110314 | 9.23525641109e-05 | 0.375 | CUL4A RBX1 CUL4B | Recognition of DNA damage by PCNA-containing replication complex |
| WP:WP4753 | 0.000119980221063 | 0.375 | CUL4A RBX1 CUL4B | Nucleotide excision repair |
| CORUM:2172 | 0.000143457417375 | 0.25 | CUL4A RBX1 | Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) |
| KEGG:03420 | 0.000162137358357 | 0.375 | CUL4A RBX1 CUL4B | Nucleotide excision repair |
| REAC:R-HSA-5696394 | 0.000191499085287 | 0.375 | CUL4A RBX1 CUL4B | DNA Damage Recognition in GG-NER |
| CORUM:1214 | 0.000239030245992 | 0.25 | CUL4A RBX1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| REAC:R-HSA-5696400 | 0.000241797870321 | 0.375 | CUL4A RBX1 CUL4B | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.000260330782854 | 0.375 | CUL4A RBX1 CUL4B | Formation of Incision Complex in GG-NER |
| CORUM:1211 | 0.000358447219737 | 0.25 | RBX1 CUL4B | Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) |
| REAC:R-HSA-73893 | 0.000367233569698 | 0.375 | CUL4A RBX1 CUL4B | DNA Damage Bypass |
| GO:1990234 | 0.000446438652387 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | transferase complex |
| REAC:R-HSA-6781823 | 0.000499872649354 | 0.375 | CUL4A RBX1 CUL4B | Formation of TC-NER Pre-Incision Complex |
| WP:WP5114 | 0.000600026967084 | 0.375 | CUL4A RBX1 CUL4B | Nucleotide excision repair in xeroderma pigmentosum |
| GO:0140535 | 0.000666832615666 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | intracellular protein-containing complex |
| REAC:R-HSA-6782210 | 0.00089567252269 | 0.375 | CUL4A RBX1 CUL4B | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.000939480277464 | 0.375 | CUL4A RBX1 CUL4B | Dual incision in TC-NER |
| CORUM:726 | 0.00157457895347 | 0.25 | CUL4A RBX1 | DDB2 complex |
| CORUM:727 | 0.00157457895347 | 0.25 | CUL4A RBX1 | CSA complex |
| CORUM:728 | 0.00157457895347 | 0.25 | CUL4A RBX1 | CSA-POLIIa complex |
| REAC:R-HSA-6781827 | 0.00164394868368 | 0.375 | CUL4A RBX1 CUL4B | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 0.00206171621711 | 0.375 | CUL4A RBX1 CUL4B | Global Genome Nucleotide Excision Repair (GG-NER) |
| KEGG:04120 | 0.00206570877774 | 0.375 | CUL4A RBX1 CUL4B | Ubiquitin mediated proteolysis |
| WP:WP4946 | 0.00223564396029 | 0.375 | CUL4A RBX1 CUL4B | DNA repair pathways full network |
| REAC:R-HSA-5696398 | 0.00455165033631 | 0.375 | CUL4A RBX1 CUL4B | Nucleotide Excision Repair |
| KEGG:05170 | 0.00598640884546 | 0.375 | CUL4A RBX1 CUL4B | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-597592 | 0.0405127359976 | 0.625 | CUL4A CUL4B DCAF16 DDA1 RBX1 | Post-translational protein modification |
| GO:1902494 | 0.049033393423 | 0.875 | CUL4A CRBN DDA1 RBX1 DCAF16 CUL4B DCAF8L2 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CUL4A | CUL4B | 0.999 | 0.374 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CUL4A | DDA1 | 0.999 | 0.12 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CUL4A | RBX1 | 0.998 | 0.878 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| CRBN | CUL4B | 0.997 | 0.136 |
structurally_consistent (Q16531)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL4B | DCAF16 | 0.997 | 0.128 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CUL4A | BRWD3 | 0.996 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| CUL4B | RBX1 | 0.996 | 0.138 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () | |
| CUL4B | DDA1 | 0.994 | 0.092 |
structurally_consistent (Q16531)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| BRWD3 | DDA1 | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| CRBN | CUL4A | 0.985 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CUL4B | BRWD3 | 0.955 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| BRWD3 | RBX1 | 0.941 | hein_WMM hein () | ||
| CUL4A | DCAF16 | 0.927 | 0.198 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| DCAF16 | DDA1 | 0.849 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RBX1 | DDA1 | 0.785 | 0.306 | hein_WMM WMM_only | |
| CRBN | RBX1 | 0.75 | 0.3 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CRBN | DCAF16 | 0.545 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| RBX1 | DCAF16 | 0.461 | 0.274 | hein_WMM bioplex3_WMM WMM_only | |
| CRBN | DDA1 | 0.058 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes