hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02961.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56) | 5 | UniProt NCBI |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54) | 5 | UniProt NCBI |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) | 5 | UniProt NCBI |
| PHACTR4 | Phosphatase and actin regulator 4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-909733 | 5.03512663474e-05 | 0.75 | IFIT2 IFIT1 IFIT3 | Interferon alpha/beta signaling |
| WP:WP4197 | 0.000484429625977 | 0.5 | IFIT1 IFIT3 | Immune response to tuberculosis |
| TF:M11670_1 | 0.000883305813556 | 0.75 | PHACTR4 IFIT1 IFIT3 | Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 |
| REAC:R-HSA-913531 | 0.00122110889015 | 0.75 | IFIT2 IFIT1 IFIT3 | Interferon Signaling |
| TF:M11665_1 | 0.00124298263937 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 |
| TF:M04014 | 0.00184343006403 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR |
| TF:M04020_1 | 0.00190418300832 | 0.75 | PHACTR4 IFIT1 IFIT3 | Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 |
| TF:M00453_1 | 0.00309468405264 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 |
| TF:M09733_1 | 0.00320350035918 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 |
| GO:0140374 | 0.00350727150095 | 0.75 | IFIT2 IFIT1 IFIT3 | antiviral innate immune response |
| TF:M00772_1 | 0.0037914498893 | 0.75 | IFIT2 IFIT1 IFIT3 | Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 |
| TF:M08887_1 | 0.0089837173405 | 0.75 | IFIT2 IFIT1 IFIT3 | Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 |
| TF:M11686_1 | 0.0103222422745 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 |
| TF:M11687_1 | 0.0181092817595 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 |
| TF:M07045 | 0.0229807489815 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-1; motif: NNRAAANNGAAASN |
| TF:M11682_1 | 0.0239624415377 | 1.0 | IFIT2 PHACTR4 IFIT1 IFIT3 | Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IFIT2 | PHACTR4 | 0.993 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT3 | PHACTR4 | 0.991 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT2 | IFIT3 | 0.988 | 0.534 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT1 | PHACTR4 | 0.988 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT1 | IFIT2 | 0.986 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IFIT1 | IFIT3 | 0.925 | 0.576 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| IFIT1 | huMAP3_02961.1 huMAP3_09614.1 huMAP3_11921.1 huMAP3_14555.1 |
| IFIT2 | huMAP3_02961.1 huMAP3_07780.1 huMAP3_09614.1 |
| IFIT3 | huMAP3_02961.1 huMAP3_09614.1 huMAP3_11921.1 |
| PHACTR4 | huMAP3_02961.1 huMAP3_07780.1 huMAP3_09614.1 huMAP3_14555.1 |