hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02963.1

Complex Portal: CPX-24682

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
LAMTOR1	Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)	5	UniProt NCBI
LAMTOR2	Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)	5	UniProt NCBI
RRAGC	Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)	5	UniProt NCBI
RRAGD	Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)	5	UniProt NCBI
SLC38A9	Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)	5	UniProt NCBI
SMYD5	Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5)	5	UniProt NCBI

Showing 1 to 6 of 6 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-166208	8.43326163254e-12	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	mTORC1-mediated signalling
REAC:R-HSA-380972	2.35555725816e-11	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	Energy dependent regulation of mTOR by LKB1-AMPK
REAC:R-HSA-165159	1.48544481847e-10	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	MTOR signalling
REAC:R-HSA-9639288	5.68434264714e-10	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	Amino acids regulate mTORC1
REAC:R-HSA-8943724	8.29202508616e-10	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	Regulation of PTEN gene transcription
REAC:R-HSA-5628897	4.45764769353e-09	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	TP53 Regulates Metabolic Genes
GO:0071230	1.5008288106e-08	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	cellular response to amino acid stimulus
GO:0071229	2.35069376956e-08	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	cellular response to acid chemical
KEGG:04150	3.06586313087e-08	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	mTOR signaling pathway
GO:0043200	3.1045722158e-08	0.833333333333	RRAGC SLC38A9 RRAGD LAMTOR1 LAMTOR2	response to amino acid

Showing 1 to 10 of 45 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
LAMTOR2	LAMTOR1	1.0	0.872		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
RRAGC	LAMTOR1	0.998	0.262	mutually_exclusive (Q9NQL2)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SLC38A9	LAMTOR1	0.998	0.250911392405		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
RRAGC	LAMTOR2	0.998	0.112		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SLC38A9	LAMTOR2	0.997	0.194		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
RRAGD	LAMTOR1	0.994		structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SLC38A9	RRAGC	0.984	0.046		bioplex_WMM bioplex3_WMM WMM_only
LAMTOR1	SMYD5	0.975	0.108		hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
RRAGC	RRAGD	0.973		structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
RRAGD	LAMTOR2	0.965			bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only

Showing 1 to 10 of 12 entries

Related Complexes

Genename	Complexes
RRAGD	huMAP3_01903.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_14108.1 huMAP3_14708.1 huMAP3_14711.1
SLC38A9	huMAP3_00620.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR2	huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_12042.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR1	huMAP3_02963.1 huMAP3_03143.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10047.1 huMAP3_14108.1 huMAP3_14708.1
RRAGC	huMAP3_00620.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_14108.1 huMAP3_14708.1
SMYD5	huMAP3_02963.1 huMAP3_03143.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10047.1 huMAP3_11707.1 huMAP3_11900.1 huMAP3_12868.1 huMAP3_14418.1 huMAP3_15139.1