hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02963.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRAGD | Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-) | 5 | UniProt NCBI |
| SLC38A9 | Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11) | 5 | UniProt NCBI |
| LAMTOR2 | Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3) | 5 | UniProt NCBI |
| LAMTOR1 | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | 5 | UniProt NCBI |
| RRAGC | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | 5 | UniProt NCBI |
| SMYD5 | Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-166208 | 8.43326163254e-12 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | mTORC1-mediated signalling |
| REAC:R-HSA-380972 | 2.35555725816e-11 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 1.48544481847e-10 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | MTOR signalling |
| REAC:R-HSA-9639288 | 5.68434264714e-10 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Amino acids regulate mTORC1 |
| REAC:R-HSA-8943724 | 8.29202508616e-10 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-5628897 | 4.45764769353e-09 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | TP53 Regulates Metabolic Genes |
| GO:0071230 | 1.5008288106e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | cellular response to amino acid stimulus |
| GO:0071229 | 2.35069376956e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | cellular response to acid chemical |
| KEGG:04150 | 3.06586313087e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | mTOR signaling pathway |
| GO:0043200 | 3.1045722158e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | response to amino acid |
| REAC:R-HSA-1632852 | 4.81742407112e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Macroautophagy |
| GO:0001101 | 5.18929314326e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | response to acid chemical |
| REAC:R-HSA-6807070 | 6.83531567593e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | PTEN Regulation |
| GO:1990877 | 8.28303368884e-08 | 0.666666666667 | SLC38A9 RRAGC LAMTOR1 LAMTOR2 | FNIP-folliculin RagC/D GAP |
| REAC:R-HSA-9612973 | 8.5199094395e-08 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Autophagy |
| GO:1904263 | 1.14175047996e-07 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | positive regulation of TORC1 signaling |
| REAC:R-HSA-9711097 | 1.28814034961e-07 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Cellular response to starvation |
| GO:1902773 | 1.30147699894e-07 | 0.666666666667 | SLC38A9 RRAGC LAMTOR1 LAMTOR2 | GTPase activator complex |
| GO:0032008 | 4.44724347983e-07 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | positive regulation of TOR signaling |
| GO:0150005 | 7.17391174374e-07 | 0.666666666667 | SLC38A9 RRAGC LAMTOR1 LAMTOR2 | enzyme activator complex |
| REAC:R-HSA-1257604 | 1.00664938557e-06 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | PIP3 activates AKT signaling |
| GO:1903432 | 1.7640596292e-06 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | regulation of TORC1 signaling |
| REAC:R-HSA-9006925 | 2.05170045467e-06 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Intracellular signaling by second messengers |
| GO:0038202 | 2.23176181384e-06 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | TORC1 signaling |
| REAC:R-HSA-3700989 | 6.9535138865e-06 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Transcriptional Regulation by TP53 |
| GO:0032006 | 1.20814684781e-05 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | regulation of TOR signaling |
| GO:0031929 | 2.07823329526e-05 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | TOR signaling |
| GO:0071986 | 3.84302573496e-05 | 0.5 | SLC38A9 LAMTOR1 LAMTOR2 | Ragulator complex |
| REAC:R-HSA-2262752 | 0.000309290917502 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.000324464342864 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Cellular responses to stimuli |
| CORUM:6888 | 0.00155157094875 | 0.333333333333 | LAMTOR2 LAMTOR1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| REAC:R-HSA-212436 | 0.00174662531744 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Generic Transcription Pathway |
| GO:0071417 | 0.00178183624348 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | cellular response to organonitrogen compound |
| GO:0032045 | 0.00185822071527 | 0.5 | SLC38A9 LAMTOR1 LAMTOR2 | guanyl-nucleotide exchange factor complex |
| REAC:R-HSA-73857 | 0.00300615431734 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | RNA Polymerase II Transcription |
| GO:1901699 | 0.00335545189976 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | cellular response to nitrogen compound |
| REAC:R-HSA-74160 | 0.00558415609329 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Gene expression (Transcription) |
| WP:WP1471 | 0.00561973689916 | 0.333333333333 | RRAGC RRAGD | Target of rapamycin signaling |
| GO:0010243 | 0.00874179249959 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | response to organonitrogen compound |
| GO:1901698 | 0.0177538025676 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | response to nitrogen compound |
| GO:0005764 | 0.026442044167 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | lysosome |
| GO:0000323 | 0.026442044167 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | lytic vacuole |
| GO:1990131 | 0.042122686785 | 0.333333333333 | RRAGC RRAGD | Gtr1-Gtr2 GTPase complex |
| GO:0005773 | 0.0427446223865 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | vacuole |
| REAC:R-HSA-162582 | 0.0495022563739 | 0.833333333333 | SLC38A9 LAMTOR1 RRAGD RRAGC LAMTOR2 | Signal Transduction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LAMTOR2 | LAMTOR1 | 1.0 | 0.872 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGC | LAMTOR1 | 0.998 | 0.262 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SLC38A9 | LAMTOR1 | 0.998 | 0.250911392405 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGC | LAMTOR2 | 0.998 | 0.112 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SLC38A9 | LAMTOR2 | 0.997 | 0.194 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGD | LAMTOR1 | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC38A9 | RRAGC | 0.984 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only |
| LAMTOR1 | SMYD5 | 0.975 | 0.108 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| RRAGC | RRAGD | 0.973 | bioplex_WMM bioplex3_WMM WMM_only | |
| RRAGD | LAMTOR2 | 0.965 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SLC38A9 | RRAGD | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAMTOR2 | SMYD5 | 0.076 | 0.036 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes