hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02978.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | 5 | UniProt NCBI |
| HK1 | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | 5 | UniProt NCBI |
| GCK | Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) | 5 | UniProt NCBI |
| HK3 | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 5.22391527589e-10 | 1.0 | HK3 HK2 GCK | Neomycin, kanamycin and gentamicin biosynthesis |
| WP:WP5394 | 9.30193945901e-09 | 1.0 | HK3 HK2 GCK | UDP derived sugars synthesis in fibroblasts |
| KEGG:00500 | 1.20150051346e-07 | 1.0 | HK3 HK2 GCK | Starch and sucrose metabolism |
| KEGG:00052 | 1.35821797173e-07 | 1.0 | HK3 HK2 GCK | Galactose metabolism |
| KEGG:01250 | 3.41905254807e-07 | 1.0 | HK3 HK2 GCK | Biosynthesis of nucleotide sugars |
| KEGG:04930 | 5.5686936841e-07 | 1.0 | HK3 HK2 GCK | Type II diabetes mellitus |
| KEGG:00520 | 7.41273577649e-07 | 1.0 | HK3 HK2 GCK | Amino sugar and nucleotide sugar metabolism |
| WP:WP534 | 8.89885541579e-07 | 1.0 | HK3 HK2 GCK | Glycolysis and gluconeogenesis |
| GO:0004340 | 9.61200410764e-07 | 1.0 | HK3 HK2 GCK | glucokinase activity |
| GO:0004396 | 9.61200410764e-07 | 1.0 | HK3 HK2 GCK | hexokinase activity |
| GO:0008865 | 9.61200410764e-07 | 1.0 | HK3 HK2 GCK | fructokinase activity |
| KEGG:00010 | 1.97568475734e-06 | 1.0 | HK3 HK2 GCK | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 2.50251661292e-06 | 1.0 | HK3 HK2 GCK | Central carbon metabolism in cancer |
| WP:WP5355 | 7.93300403529e-06 | 1.0 | HK3 HK2 GCK | Metabolic Epileptic Disorders |
| KEGG:01200 | 9.51295867401e-06 | 1.0 | HK3 HK2 GCK | Carbon metabolism |
| GO:0046835 | 1.15344049292e-05 | 1.0 | HK3 HK2 GCK | carbohydrate phosphorylation |
| KEGG:04910 | 1.7003844223e-05 | 1.0 | HK3 HK2 GCK | Insulin signaling pathway |
| REAC:R-HSA-70171 | 2.03811815253e-05 | 1.0 | HK3 HK2 GCK | Glycolysis |
| REAC:R-HSA-70326 | 3.68984307198e-05 | 1.0 | HK3 HK2 GCK | Glucose metabolism |
| GO:0006735 | 5.38272230028e-05 | 1.0 | HK3 HK2 GCK | NADH regeneration |
| GO:0061621 | 5.38272230028e-05 | 1.0 | HK3 HK2 GCK | canonical glycolysis |
| GO:0061718 | 5.38272230028e-05 | 1.0 | HK3 HK2 GCK | glucose catabolic process to pyruvate |
| GO:0061620 | 6.5361627932e-05 | 1.0 | HK3 HK2 GCK | glycolytic process through glucose-6-phosphate |
| GO:0061615 | 6.5361627932e-05 | 1.0 | HK3 HK2 GCK | glycolytic process through fructose-6-phosphate |
| GO:0019677 | 7.84339535184e-05 | 1.0 | HK3 HK2 GCK | NAD catabolic process |
| GO:0006007 | 9.31403198031e-05 | 1.0 | HK3 HK2 GCK | glucose catabolic process |
| GO:0019200 | 0.000109576846827 | 1.0 | HK3 HK2 GCK | carbohydrate kinase activity |
| GO:0051156 | 0.000194546963139 | 1.0 | HK3 HK2 GCK | glucose 6-phosphate metabolic process |
| GO:0006734 | 0.000221076094476 | 1.0 | HK3 HK2 GCK | NADH metabolic process |
| GO:0019320 | 0.000351222630093 | 1.0 | HK3 HK2 GCK | hexose catabolic process |
| KEGG:00051 | 0.000427625786548 | 0.666666666667 | HK2 HK3 | Fructose and mannose metabolism |
| GO:0046365 | 0.000432059584639 | 1.0 | HK3 HK2 GCK | monosaccharide catabolic process |
| KEGG:04973 | 0.000453521779354 | 0.666666666667 | HK2 HK3 | Carbohydrate digestion and absorption |
| WP:WP500 | 0.000753202688136 | 0.666666666667 | HK2 HK3 | Glycogen synthesis and degradation |
| REAC:R-HSA-71387 | 0.0012894643491 | 1.0 | HK3 HK2 GCK | Metabolism of carbohydrates |
| GO:0019674 | 0.00145910222354 | 1.0 | HK3 HK2 GCK | NAD metabolic process |
| WP:WP4018 | 0.0031328951477 | 0.666666666667 | HK2 HK3 | Clear cell renal cell carcinoma pathways |
| KEGG:04066 | 0.00368672413844 | 0.666666666667 | HK2 HK3 | HIF-1 signaling pathway |
| GO:0006096 | 0.00419852339422 | 1.0 | HK3 HK2 GCK | glycolytic process |
| GO:0046032 | 0.00419852339422 | 1.0 | HK3 HK2 GCK | ADP catabolic process |
| GO:0046031 | 0.00439845307966 | 1.0 | HK3 HK2 GCK | ADP metabolic process |
| GO:0009137 | 0.00460463056777 | 1.0 | HK3 HK2 GCK | purine nucleoside diphosphate catabolic process |
| GO:0009181 | 0.00460463056777 | 1.0 | HK3 HK2 GCK | purine ribonucleoside diphosphate catabolic process |
| GO:0019364 | 0.00481715197859 | 1.0 | HK3 HK2 GCK | pyridine nucleotide catabolic process |
| GO:0009179 | 0.00481715197859 | 1.0 | HK3 HK2 GCK | purine ribonucleoside diphosphate metabolic process |
| GO:0009135 | 0.00503611343216 | 1.0 | HK3 HK2 GCK | purine nucleoside diphosphate metabolic process |
| GO:0001678 | 0.00503611343216 | 1.0 | HK3 HK2 GCK | intracellular glucose homeostasis |
| GO:0009191 | 0.00526161104852 | 1.0 | HK3 HK2 GCK | ribonucleoside diphosphate catabolic process |
| GO:0072526 | 0.00549374094772 | 1.0 | HK3 HK2 GCK | pyridine-containing compound catabolic process |
| GO:0009134 | 0.0057325992498 | 1.0 | HK3 HK2 GCK | nucleoside diphosphate catabolic process |
| GO:0009185 | 0.00675723888767 | 1.0 | HK3 HK2 GCK | ribonucleoside diphosphate metabolic process |
| GO:0009132 | 0.00789722257484 | 1.0 | HK3 HK2 GCK | nucleoside diphosphate metabolic process |
| GO:0006090 | 0.0105478288276 | 1.0 | HK3 HK2 GCK | pyruvate metabolic process |
| GO:0009154 | 0.0120707547584 | 1.0 | HK3 HK2 GCK | purine ribonucleotide catabolic process |
| GO:0009261 | 0.0128843147861 | 1.0 | HK3 HK2 GCK | ribonucleotide catabolic process |
| GO:0006195 | 0.0146194737676 | 1.0 | HK3 HK2 GCK | purine nucleotide catabolic process |
| GO:0072523 | 0.0165038110528 | 1.0 | HK3 HK2 GCK | purine-containing compound catabolic process |
| GO:0016052 | 0.0175038439602 | 1.0 | HK3 HK2 GCK | carbohydrate catabolic process |
| GO:0006006 | 0.0180186629002 | 1.0 | HK3 HK2 GCK | glucose metabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | HK3 HK2 GCK | Metabolic pathways |
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | HK2 HK3 | Shigellosis |
| GO:0042593 | 0.0231134095574 | 1.0 | HK3 HK2 GCK | glucose homeostasis |
| GO:0009166 | 0.023732518742 | 1.0 | HK3 HK2 GCK | nucleotide catabolic process |
| GO:0033500 | 0.0243625856112 | 1.0 | HK3 HK2 GCK | carbohydrate homeostasis |
| GO:0019362 | 0.0263194935275 | 1.0 | HK3 HK2 GCK | pyridine nucleotide metabolic process |
| GO:0046496 | 0.0263194935275 | 1.0 | HK3 HK2 GCK | nicotinamide nucleotide metabolic process |
| GO:1901292 | 0.0269943523359 | 1.0 | HK3 HK2 GCK | nucleoside phosphate catabolic process |
| GO:0072524 | 0.0290879429506 | 1.0 | HK3 HK2 GCK | pyridine-containing compound metabolic process |
| GO:0019318 | 0.0335943388364 | 1.0 | HK3 HK2 GCK | hexose metabolic process |
| GO:0005996 | 0.043021407985 | 1.0 | HK3 HK2 GCK | monosaccharide metabolic process |
| REAC:R-HSA-5619073 | 0.0498224659464 | 0.333333333333 | GCK | Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HK2 | HK1 | 0.999 | 0.306 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| HK3 | HK2 | 0.998 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GCK | HK3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HK3 | HK1 | 0.996 | 0.036 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GCK | HK2 | 0.12 | bioplex3_WMM WMM_only | |
| GCK | HK1 | 0.116 | bioplex3_WMM WMM_only |
Related Complexes