hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02982.1
Complex Portal: CPX-10855
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PARD6A | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | 5 | UniProt NCBI |
| PRKCZ | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | 5 | UniProt NCBI |
| BEGAIN | Brain-enriched guanylate kinase-associated protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2173791 | 0.000715513386354 | 0.666666666667 | PARD6A PRKCZ | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| WP:WP5090 | 0.00441821815069 | 0.666666666667 | PARD6A PRKCZ | Complement system in neuronal development and plasticity |
| KEGG:04530 | 0.00727572841175 | 0.666666666667 | PARD6A PRKCZ | Tight junction |
| KEGG:04390 | 0.00802719593767 | 0.666666666667 | PARD6A PRKCZ | Hippo signaling pathway |
| KEGG:04360 | 0.00893090716082 | 0.666666666667 | PARD6A PRKCZ | Axon guidance |
| KEGG:04015 | 0.010376143546 | 0.666666666667 | PARD6A PRKCZ | Rap1 signaling pathway |
| KEGG:04144 | 0.0200670831031 | 0.666666666667 | PARD6A PRKCZ | Endocytosis |
| GO:0120157 | 0.0210651876021 | 0.666666666667 | PARD6A PRKCZ | PAR polarity complex |
| REAC:R-HSA-170834 | 0.0254089329805 | 0.666666666667 | PARD6A PRKCZ | Signaling by TGF-beta Receptor Complex |
| KEGG:05165 | 0.0324411425615 | 0.666666666667 | PARD6A PRKCZ | Human papillomavirus infection |
| REAC:R-HSA-9006936 | 0.0392065258044 | 0.666666666667 | PARD6A PRKCZ | Signaling by TGFB family members |
| CORUM:829 | 0.0499402709677 | 0.333333333333 | PARD6A | PAR-6-VE-cadherin complex, endothelial |
| CORUM:6790 | 0.0499402709677 | 0.333333333333 | PRKCZ | NHERF1-PRKCZ complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PARD6A | PRKCZ | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKCZ | BEGAIN | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PARD6A | BEGAIN | 0.902 | bioplex3_WMM WMM_only |
Related Complexes