hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02983.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | 5 | UniProt NCBI |
| UQCRB | Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) | 5 | UniProt NCBI |
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4921 | 3.52698537821e-08 | 1.0 | MT-CYB UQCRQ UQCR10 | Mitochondrial complex III assembly |
| KEGG:04260 | 3.11554307054e-06 | 1.0 | MT-CYB UQCRQ UQCR10 | Cardiac muscle contraction |
| WP:WP111 | 1.17898981996e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Oxidative phosphorylation |
| GO:0006122 | 1.58598067776e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0005750 | 2.11464090368e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | mitochondrial respiratory chain complex III |
| GO:0045275 | 2.11464090368e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | respiratory chain complex III |
| KEGG:04932 | 2.28801742777e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 3.24963255001e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Nonalcoholic fatty liver disease |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-611105 | 7.31860792369e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Respiratory electron transport |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | MT-CYB UQCRQ UQCR10 | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | MT-CYB UQCRQ UQCR10 | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | MT-CYB UQCRQ UQCR10 | Prion disease |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | MT-CYB UQCRQ UQCR10 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | MT-CYB UQCRQ UQCR10 | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | MT-CYB UQCRQ UQCR10 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | MT-CYB UQCRQ UQCR10 | Alzheimer disease |
| GO:0070069 | 0.000351222630093 | 1.0 | MT-CYB UQCRQ UQCR10 | cytochrome complex |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | MT-CYB UQCRQ UQCR10 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | MT-CYB UQCRQ UQCR10 | Pathways of neurodegeneration - multiple diseases |
| GO:0019646 | 0.00675723888767 | 1.0 | MT-CYB UQCRQ UQCR10 | aerobic electron transport chain |
| GO:0098803 | 0.00760107672828 | 1.0 | MT-CYB UQCRQ UQCR10 | respiratory chain complex |
| GO:0008121 | 0.00842684400117 | 0.666666666667 | MT-CYB UQCR10 | ubiquinol-cytochrome-c reductase activity |
| GO:0042773 | 0.00851239083773 | 1.0 | MT-CYB UQCRQ UQCR10 | ATP synthesis coupled electron transport |
| GO:0042775 | 0.00851239083773 | 1.0 | MT-CYB UQCRQ UQCR10 | mitochondrial ATP synthesis coupled electron transport |
| GO:0070469 | 0.00949377645712 | 1.0 | MT-CYB UQCRQ UQCR10 | respirasome |
| GO:0005746 | 0.00949377645712 | 1.0 | MT-CYB UQCRQ UQCR10 | mitochondrial respirasome |
| GO:0022904 | 0.0116771431902 | 1.0 | MT-CYB UQCRQ UQCR10 | respiratory electron transport chain |
| GO:0016679 | 0.0140440992017 | 0.666666666667 | MT-CYB UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0022900 | 0.0150763323228 | 1.0 | MT-CYB UQCRQ UQCR10 | electron transport chain |
| HP:0003200 | 0.0167410266547 | 0.666666666667 | MT-CYB UQCRQ | Ragged-red muscle fibers |
| KEGG:01100 | 0.0189521995452 | 1.0 | MT-CYB UQCRQ UQCR10 | Metabolic pathways |
| GO:1990204 | 0.0219076797621 | 1.0 | MT-CYB UQCRQ UQCR10 | oxidoreductase complex |
| GO:0006119 | 0.025655976884 | 1.0 | MT-CYB UQCRQ UQCR10 | oxidative phosphorylation |
| GO:0098800 | 0.0498541011049 | 1.0 | MT-CYB UQCRQ UQCR10 | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UQCRB | UQCRQ | 0.996 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| MT-CYB | UQCRQ | 0.995 | 0.77 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCR10 | UQCRQ | 0.994 | 0.766 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| MT-CYB | UQCRB | 0.981 | 0.814 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MT-CYB | UQCR10 | 0.966 | 0.612 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| UQCRB | UQCR10 | 0.965 | 0.914 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes