hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02985.1
Complex Portal: CPX-21348
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPUSD3 | Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) | 5 | UniProt NCBI |
| RCC1L | RCC1-like G exchanging factor-like protein (RCC1-like) (Williams-Beuren syndrome chromosomal region 16 protein) | 5 | UniProt NCBI |
| NGRN | Neugrin (Mesenchymal stem cell protein DSC92) (Neurite outgrowth-associated protein) (Spinal cord-derived protein FI58G) | 5 | UniProt NCBI |
| NME6 | Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) (Inhibitor of p53-induced apoptosis-alpha) (IPIA-alpha) (nm23-H6) | 5 | UniProt NCBI |
| FASTKD2 | FAST kinase domain-containing protein 2, mitochondrial | 5 | UniProt NCBI |
| PIGY | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (Phosphatidylinositol-glycan biosynthesis class Y protein) (PIG-Y) | 5 | UniProt NCBI |
| MCAT | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070131 | 1.25481586619e-06 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | positive regulation of mitochondrial translation |
| GO:0070129 | 6.71679244503e-06 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | regulation of mitochondrial translation |
| GO:0062125 | 8.1295172324e-06 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | regulation of mitochondrial gene expression |
| GO:0045727 | 0.00503558984177 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | positive regulation of translation |
| GO:0032543 | 0.00874901431253 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | mitochondrial translation |
| GO:0034250 | 0.00993228783009 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | positive regulation of amide metabolic process |
| GO:0140053 | 0.0197221628961 | 0.571428571429 | RPUSD3 NGRN FASTKD2 RCC1L | mitochondrial gene expression |
| GO:0019843 | 0.0473277551461 | 0.428571428571 | RCC1L FASTKD2 NGRN | rRNA binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPUSD3 | FASTKD2 | 0.998 | 0.35 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCC1L | NME6 | 0.998 | 0.242 |
mutually_exclusive (O95900)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCC1L | FASTKD2 | 0.995 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NGRN | RCC1L | 0.995 | 0.294 |
structurally_consistent (Q9Y2Z4)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NGRN | FASTKD2 | 0.993 | 0.076 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| RPUSD3 | RCC1L | 0.991 | 0.478 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NGRN | MCAT | 0.99 | 0.308 |
structurally_consistent (Q9Y2Z4)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPUSD3 | NGRN | 0.987 | 0.224 |
structurally_consistent (Q9NYY8)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MCAT | RCC1L | 0.982 | 0.279333333333 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCAT | FASTKD2 | 0.98 | 0.06 |
structurally_consistent (Q96CM3)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RCC1L | PIGY | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RPUSD3 | MCAT | 0.979 | 0.342 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NME6 | PIGY | 0.892 | bioplex3_WMM WMM_only | ||
| MCAT | PIGY | 0.188 | bioplex3_WMM WMM_only | ||
| MCAT | NME6 | 0.082 | 0.152 | bioplex3_WMM WMM_only | |
| NME6 | FASTKD2 | 0.025 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPUSD3 | NME6 | 0.023 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| NGRN | NME6 | 0.019 | 0.162 | bioplex3_WMM WMM_only | |
| NGRN | PIGY | 0.013 | bioplex3_WMM WMM_only |
Related Complexes