hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03009.1
Complex Portal: CPX-24584
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OTUD3 | OTU domain-containing protein 3 (EC 3.4.19.12) | 5 | UniProt NCBI |
| GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | 5 | UniProt NCBI |
| GNA13 | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) | 5 | UniProt NCBI |
| HRAS | GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1905360 | 0.00274053853655 | 0.75 | GNA13 GNAT3 HRAS | GTPase complex |
| KEGG:04730 | 0.00281740883519 | 0.5 | GNA13 HRAS | Long-term depression |
| WP:WP2032 | 0.00377411060353 | 0.5 | GNA13 HRAS | Thyroid stimulating hormone TSH signaling pathway |
| REAC:R-HSA-392518 | 0.00444848198459 | 0.5 | GNA13 GNAT3 | Signal amplification |
| WP:WP35 | 0.00761604886135 | 0.5 | GNA13 HRAS | G protein signaling pathways |
| REAC:R-HSA-388396 | 0.0112517828268 | 0.75 | GNA13 GNAT3 HRAS | GPCR downstream signalling |
| KEGG:04071 | 0.0130545606238 | 0.5 | GNA13 HRAS | Sphingolipid signaling pathway |
| KEGG:04371 | 0.015160801965 | 0.5 | GNA13 HRAS | Apelin signaling pathway |
| KEGG:04072 | 0.0165563012031 | 0.5 | GNA13 HRAS | Phospholipase D signaling pathway |
| REAC:R-HSA-372790 | 0.0165968987372 | 0.75 | GNA13 GNAT3 HRAS | Signaling by GPCR |
| REAC:R-HSA-9009391 | 0.019281632575 | 0.5 | HRAS GNAT3 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-109582 | 0.0327468558633 | 0.75 | GNA13 GNAT3 HRAS | Hemostasis |
| KEGG:05163 | 0.0451972531521 | 0.5 | GNA13 HRAS | Human cytomegalovirus infection |
| KEGG:04810 | 0.0466115978004 | 0.5 | GNA13 HRAS | Regulation of actin cytoskeleton |
| CORUM:5922 | 0.049938562206 | 0.25 | HRAS | RAF1-RAS complex, EGF induced |
| CORUM:6219 | 0.049938562206 | 0.25 | HRAS | DGKZ-RASGRP1-HRAS complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| OTUD3 | GNAT3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OTUD3 | HRAS | 0.984 | 0.296 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OTUD3 | GNA13 | 0.961 | 0.202 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HRAS | GNA13 | 0.835 | 0.258 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNAT3 | GNA13 | 0.498 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GNAT3 | HRAS | 0.297 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes