hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03010.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CEBPA | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | 5 | UniProt NCBI |
| CEBPB | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | 5 | UniProt NCBI |
| DDIT3 | DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4211 | 1.27901667561e-08 | 1.0 | CEBPA DDIT3 CEBPB | Transcriptional cascade regulating adipogenesis |
| GO:0036488 | 9.61200410764e-08 | 1.0 | CEBPA DDIT3 CEBPB | CHOP-C/EBP complex |
| WP:WP4149 | 1.78287172964e-07 | 1.0 | CEBPA DDIT3 CEBPB | White fat cell differentiation |
| WP:WP236 | 1.5385795446e-05 | 1.0 | CEBPA DDIT3 CEBPB | Adipogenesis |
| KEGG:05202 | 3.17971886971e-05 | 1.0 | CEBPA DDIT3 CEBPB | Transcriptional misregulation in cancer |
| WP:WP3599 | 0.000193548942551 | 0.666666666667 | CEBPA CEBPB | Transcription factor regulation in adipogenesis |
| WP:WP2895 | 0.000237669979309 | 0.666666666667 | CEBPA CEBPB | Differentiation of white and brown adipocyte |
| WP:WP2817 | 0.000367738611184 | 0.666666666667 | CEBPA CEBPB | Mammary gland development pathway Pregnancy and lactation Stage 3 of 4 |
| WP:WP4844 | 0.000492114068528 | 0.666666666667 | CEBPA CEBPB | Influence of laminopathies on Wnt signaling |
| REAC:R-HSA-9648895 | 0.000620139908703 | 0.666666666667 | CEBPB DDIT3 | Response of EIF2AK1 (HRI) to heme deficiency |
| GO:0140467 | 0.000686297093286 | 1.0 | CEBPA DDIT3 CEBPB | integrated stress response signaling |
| WP:WP395 | 0.00122198206637 | 0.666666666667 | CEBPA CEBPB | IL 4 signaling pathway |
| WP:WP4879 | 0.00122198206637 | 0.666666666667 | CEBPA CEBPB | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:1990647 | 0.00140460216025 | 0.666666666667 | CEBPA CEBPB | C/EBP complex |
| REAC:R-HSA-380994 | 0.00221357222266 | 0.666666666667 | CEBPB DDIT3 | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 0.00316638779295 | 0.666666666667 | CEBPB DDIT3 | PERK regulates gene expression |
| KEGG:04932 | 0.00727572841175 | 0.666666666667 | CEBPA DDIT3 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 0.0104876474497 | 0.666666666667 | CEBPA DDIT3 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-9616222 | 0.0168905285744 | 0.666666666667 | CEBPA CEBPB | Transcriptional regulation of granulopoiesis |
| REAC:R-HSA-381340 | 0.0188582038017 | 0.666666666667 | CEBPA CEBPB | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-381119 | 0.023680221974 | 0.666666666667 | CEBPB DDIT3 | Unfolded Protein Response (UPR) |
| CORUM:746 | 0.0249718442456 | 0.333333333333 | CEBPA | C/EBPalpha-HNF6 complex |
| REAC:R-HSA-9633012 | 0.0336004634561 | 0.666666666667 | CEBPB DDIT3 | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| CORUM:5383 | 0.0499402709677 | 0.333333333333 | DDIT3 | TRIB3-DDIT3 complex |
| CORUM:6068 | 0.0499402709677 | 0.333333333333 | CEBPB | ESR1-CEBPB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CEBPB | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | CEBPB | 0.415 | bioplex3_WMM WMM_only |
Related Complexes