hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03011.1
Complex Portal: CPX-18470
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TTN | Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) | 5 | UniProt NCBI |
| MYOZ1 | Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ) | 5 | UniProt NCBI |
| LATS2 | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | 5 | UniProt NCBI |
| MYBPC1 | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | 5 | UniProt NCBI |
| LATS1 | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | 5 | UniProt NCBI |
| MYOM1 | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 1.79630139566e-05 | 0.5 | TTN MYBPC1 MYOM1 | Striated muscle contraction pathway |
| WP:WP4533 | 0.00153714048185 | 0.333333333333 | LATS1 LATS2 | Transcription co factors SKI and SKIL protein partners |
| WP:WP4537 | 0.00171766688832 | 0.333333333333 | LATS1 LATS2 | Hippo YAP signaling |
| KEGG:04392 | 0.00235248417572 | 0.333333333333 | LATS1 LATS2 | Hippo signaling pathway - multiple species |
| WP:WP4542 | 0.00407076266464 | 0.333333333333 | LATS1 LATS2 | Leukocyte intrinsic Hippo pathway functions |
| GO:0030016 | 0.00428601543329 | 0.666666666667 | TTN MYOM1 MYBPC1 MYOZ1 | myofibril |
| REAC:R-HSA-2028269 | 0.00440152140132 | 0.333333333333 | LATS1 LATS2 | Signaling by Hippo |
| GO:0043292 | 0.0054625416235 | 0.666666666667 | TTN MYOM1 MYBPC1 MYOZ1 | contractile fiber |
| GO:0008307 | 0.0125202207278 | 0.5 | TTN MYBPC1 MYOM1 | structural constituent of muscle |
| REAC:R-HSA-390522 | 0.0135559590666 | 0.333333333333 | TTN MYBPC1 | Striated Muscle Contraction |
| HPA:0440342 | 0.0142822139719 | 1.0 | MYOZ1 LATS2 LATS1 MYBPC1 TTN MYOM1 | skeletal muscle; myocytes[>=Medium] |
| WP:WP4540 | 0.0329770277677 | 0.333333333333 | LATS1 LATS2 | Hippo signaling regulation pathways |
| GO:0031433 | 0.042122686785 | 0.333333333333 | TTN MYOZ1 | telethonin binding |
| WP:WP4541 | 0.0451642815361 | 0.333333333333 | LATS1 LATS2 | Hippo Merlin signaling dysregulation |
| CORUM:1987 | 0.0499436884912 | 0.166666666667 | MYOM1 | MYOM1 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LATS1 | MYOZ1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | LATS2 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| LATS1 | TTN | 0.989 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | MYBPC1 | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LATS1 | MYOM1 | 0.984 | 0.074 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYOZ1 | MYBPC1 | 0.902 | bioplex3_WMM WMM_only | ||
| MYOZ1 | MYOM1 | 0.902 | bioplex3_WMM WMM_only | ||
| MYOZ1 | TTN | 0.902 | bioplex3_WMM WMM_only | ||
| TTN | MYOM1 | 0.855 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TTN | MYBPC1 | 0.765 | bioplex3_WMM WMM_only | ||
| MYBPC1 | MYOM1 | 0.564 | bioplex3_WMM WMM_only | ||
| MYOZ1 | LATS2 | 0.214 | bioplex3_WMM WMM_only | ||
| LATS2 | MYBPC1 | 0.131 | bioplex3_WMM WMM_only | ||
| LATS2 | MYOM1 | 0.055 | bioplex3_WMM WMM_only | ||
| LATS2 | TTN | 0.043 | bioplex3_WMM WMM_only |
Related Complexes