hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03020.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SGO1 | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | 5 | UniProt NCBI |
| CCNG1 | Cyclin-G1 (Cyclin-G) | 5 | UniProt NCBI |
| PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | 5 | UniProt NCBI |
| PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | 5 | UniProt NCBI |
| C1orf21 | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5117 | 5.41229412316e-06 | 0.6 | PPP2R5A SGO1 PPP2R5E | Cohesin complex Cornelia de Lange syndrome |
| KEGG:04114 | 0.000168183083601 | 0.6 | PPP2R5A SGO1 PPP2R5E | Oocyte meiosis |
| REAC:R-HSA-141444 | 0.000388335652279 | 0.6 | PPP2R5A SGO1 PPP2R5E | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.000388335652279 | 0.6 | PPP2R5A SGO1 PPP2R5E | Amplification of signal from the kinetochores |
| KEGG:04110 | 0.000516961308947 | 0.6 | PPP2R5A SGO1 PPP2R5E | Cell cycle |
| REAC:R-HSA-69618 | 0.000630278165562 | 0.6 | PPP2R5A SGO1 PPP2R5E | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.000722460713996 | 0.6 | PPP2R5A SGO1 PPP2R5E | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.000887870732144 | 0.6 | PPP2R5A SGO1 PPP2R5E | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.00115380230305 | 0.6 | PPP2R5A SGO1 PPP2R5E | RHO GTPases Activate Formins |
| REAC:R-HSA-5467348 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839735 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | Signaling by AXIN mutants |
| REAC:R-HSA-5467337 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467340 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-4839748 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | Signaling by AMER1 mutants |
| REAC:R-HSA-4839744 | 0.0013810496636 | 0.4 | PPP2R5E PPP2R5A | Signaling by APC mutants |
| REAC:R-HSA-5358751 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | CTNNB1 S45 mutants aren't phosphorylated |
| REAC:R-HSA-5358752 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | CTNNB1 T41 mutants aren't phosphorylated |
| REAC:R-HSA-5358747 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | CTNNB1 S33 mutants aren't phosphorylated |
| REAC:R-HSA-5339716 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | Signaling by GSK3beta mutants |
| REAC:R-HSA-5358749 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | CTNNB1 S37 mutants aren't phosphorylated |
| REAC:R-HSA-4839743 | 0.001593300657 | 0.4 | PPP2R5E PPP2R5A | Signaling by CTNNB1 phospho-site mutants |
| REAC:R-HSA-432142 | 0.0018206657072 | 0.4 | PPP2R5E PPP2R5A | Platelet sensitization by LDL |
| REAC:R-HSA-196299 | 0.00206313859056 | 0.4 | PPP2R5E PPP2R5A | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-389513 | 0.00232071308473 | 0.4 | PPP2R5E PPP2R5A | CTLA4 inhibitory signaling |
| REAC:R-HSA-2467813 | 0.0031285811726 | 0.6 | PPP2R5A SGO1 PPP2R5E | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.00372311058954 | 0.6 | PPP2R5A SGO1 PPP2R5E | Mitotic Prometaphase |
| WP:WP500 | 0.00389862536801 | 0.4 | PPP2R5E PPP2R5A | Glycogen synthesis and degradation |
| REAC:R-HSA-68882 | 0.00556290465695 | 0.6 | PPP2R5A SGO1 PPP2R5E | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00563783422619 | 0.6 | PPP2R5A SGO1 PPP2R5E | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-5673000 | 0.0065872694687 | 0.4 | PPP2R5E PPP2R5A | RAF activation |
| REAC:R-HSA-4641262 | 0.00704059925156 | 0.4 | PPP2R5E PPP2R5A | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-4791275 | 0.00799229651072 | 0.4 | PPP2R5E PPP2R5A | Signaling by WNT in cancer |
| REAC:R-HSA-5675221 | 0.0106339701454 | 0.4 | PPP2R5E PPP2R5A | Negative regulation of MAPK pathway |
| REAC:R-HSA-69620 | 0.0108605941756 | 0.6 | PPP2R5A SGO1 PPP2R5E | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.0129544055333 | 0.6 | PPP2R5A SGO1 PPP2R5E | RHO GTPase Effectors |
| KEGG:03015 | 0.0183886697314 | 0.4 | PPP2R5E PPP2R5A | mRNA surveillance pathway |
| KEGG:04660 | 0.0235498516465 | 0.4 | PPP2R5E PPP2R5A | T cell receptor signaling pathway |
| KEGG:04071 | 0.0235498516465 | 0.4 | PPP2R5E PPP2R5A | Sphingolipid signaling pathway |
| REAC:R-HSA-388841 | 0.0240791876622 | 0.4 | PPP2R5E PPP2R5A | Costimulation by the CD28 family |
| KEGG:04728 | 0.0263659307172 | 0.4 | PPP2R5E PPP2R5A | Dopaminergic synapse |
| KEGG:04152 | 0.028330266578 | 0.4 | PPP2R5E PPP2R5A | AMPK signaling pathway |
| REAC:R-HSA-68886 | 0.0287469323532 | 0.6 | PPP2R5A SGO1 PPP2R5E | M Phase |
| KEGG:04261 | 0.0314069031448 | 0.4 | PPP2R5E PPP2R5A | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-418346 | 0.0384836492499 | 0.4 | PPP2R5E PPP2R5A | Platelet homeostasis |
| REAC:R-HSA-6811558 | 0.0406556405791 | 0.4 | PPP2R5E PPP2R5A | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.0487218825663 | 0.4 | PPP2R5E PPP2R5A | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-195253 | 0.0487218825663 | 0.4 | PPP2R5E PPP2R5A | Degradation of beta-catenin by the destruction complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PPP2R5E | PPP2R5A | 1.0 | 0.102 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PPP2R5E | C1orf21 | 0.997 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SGO1 | PPP2R5E | 0.993 | 0.138 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPP2R5A | C1orf21 | 0.993 | 0.056375 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SGO1 | PPP2R5A | 0.993 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCNG1 | PPP2R5E | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCNG1 | PPP2R5A | 0.356 | bioplex3_WMM WMM_only | |
| SGO1 | C1orf21 | 0.076 | 0.062 | bioplex3_WMM WMM_only |
| SGO1 | CCNG1 | 0.043 | bioplex3_WMM WMM_only |
Related Complexes