hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03023.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 5 | UniProt NCBI |
| HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | 5 | UniProt NCBI |
| HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | 5 | UniProt NCBI |
| HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1296061 | 9.60315000334e-14 | 1.0 | HCN3 HCN1 HCN4 HCN2 | HCN channels |
| GO:0098855 | 2.63126310092e-11 | 1.0 | HCN3 HCN1 HCN4 HCN2 | HCN channel complex |
| GO:0005248 | 3.59167413275e-08 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated sodium channel activity |
| REAC:R-HSA-1296071 | 6.92118227041e-08 | 1.0 | HCN3 HCN1 HCN4 HCN2 | Potassium Channels |
| GO:0003254 | 3.93373833587e-07 | 1.0 | HCN3 HCN1 HCN4 HCN2 | regulation of membrane depolarization |
| GO:0005272 | 4.61786674211e-07 | 1.0 | HCN3 HCN1 HCN4 HCN2 | sodium channel activity |
| GO:0051899 | 2.6646801423e-06 | 1.0 | HCN3 HCN1 HCN4 HCN2 | membrane depolarization |
| KEGG:04929 | 4.86072516083e-06 | 0.75 | HCN3 HCN2 HCN1 | GnRH secretion |
| GO:0005249 | 6.05979892141e-06 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated potassium channel activity |
| GO:0008076 | 8.32139586928e-06 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated potassium channel complex |
| GO:0005222 | 1.34540429244e-05 | 0.75 | HCN1 HCN4 HCN2 | intracellular cAMP-activated cation channel activity |
| GO:0034705 | 1.37313780553e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | potassium channel complex |
| GO:0005267 | 1.37313780553e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | potassium channel activity |
| REAC:R-HSA-112316 | 3.09235191422e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | Neuronal System |
| GO:0005221 | 3.22863876272e-05 | 0.75 | HCN1 HCN4 HCN2 | intracellular cyclic nucleotide-activated monoatomic cation channel activity |
| GO:0043855 | 3.22863876272e-05 | 0.75 | HCN1 HCN4 HCN2 | cyclic nucleotide-activated monoatomic ion channel activity |
| GO:0022843 | 4.60223703929e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated monoatomic cation channel activity |
| GO:0035725 | 5.07702478448e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | sodium ion transmembrane transport |
| GO:0015079 | 5.32774205779e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | potassium ion transmembrane transporter activity |
| WP:WP1992 | 5.36057998926e-05 | 0.5 | HCN4 HCN2 | Genes targeted by miRNAs in adipocytes |
| GO:0015081 | 6.42456040004e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | sodium ion transmembrane transporter activity |
| GO:0022832 | 9.90506366677e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated channel activity |
| GO:0005244 | 9.90506366677e-05 | 1.0 | HCN3 HCN1 HCN4 HCN2 | voltage-gated monoatomic ion channel activity |
| GO:0006814 | 0.000157586478677 | 1.0 | HCN3 HCN1 HCN4 HCN2 | sodium ion transport |
| GO:0071805 | 0.000238882641259 | 1.0 | HCN3 HCN1 HCN4 HCN2 | potassium ion transmembrane transport |
| GO:0034703 | 0.000298882018117 | 1.0 | HCN3 HCN1 HCN4 HCN2 | cation channel complex |
| GO:0006813 | 0.000317929863268 | 1.0 | HCN3 HCN1 HCN4 HCN2 | potassium ion transport |
| GO:0005217 | 0.000510886175237 | 0.75 | HCN1 HCN4 HCN2 | intracellular ligand-gated monoatomic ion channel activity |
| GO:0034702 | 0.000822442198332 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic ion channel complex |
| GO:0022836 | 0.0010638907158 | 1.0 | HCN3 HCN1 HCN4 HCN2 | gated channel activity |
| GO:0071320 | 0.00112321912057 | 0.75 | HCN1 HCN4 HCN2 | cellular response to cAMP |
| GO:0005261 | 0.0017020312212 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic cation channel activity |
| GO:0042391 | 0.00177167286169 | 1.0 | HCN3 HCN1 HCN4 HCN2 | regulation of membrane potential |
| GO:0051591 | 0.00209449363787 | 0.75 | HCN1 HCN4 HCN2 | response to cAMP |
| GO:1902495 | 0.00379124230895 | 1.0 | HCN3 HCN1 HCN4 HCN2 | transmembrane transporter complex |
| GO:0046873 | 0.00481998395444 | 1.0 | HCN3 HCN1 HCN4 HCN2 | metal ion transmembrane transporter activity |
| GO:0005216 | 0.00512653502568 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic ion channel activity |
| GO:1990351 | 0.0052054047953 | 1.0 | HCN3 HCN1 HCN4 HCN2 | transporter complex |
| GO:0030425 | 0.00569790407237 | 1.0 | HCN3 HCN1 HCN4 HCN2 | dendrite |
| GO:0097447 | 0.00586958333309 | 1.0 | HCN3 HCN1 HCN4 HCN2 | dendritic tree |
| GO:0030424 | 0.00678688822342 | 1.0 | HCN3 HCN1 HCN4 HCN2 | axon |
| GO:0015267 | 0.00780772871207 | 1.0 | HCN3 HCN1 HCN4 HCN2 | channel activity |
| GO:0022803 | 0.00791579416137 | 1.0 | HCN3 HCN1 HCN4 HCN2 | passive transmembrane transporter activity |
| GO:0046683 | 0.00951168180783 | 0.75 | HCN1 HCN4 HCN2 | response to organophosphorus |
| GO:0014074 | 0.0118300289699 | 0.75 | HCN1 HCN4 HCN2 | response to purine-containing compound |
| GO:0022890 | 0.0143938923455 | 1.0 | HCN3 HCN1 HCN4 HCN2 | inorganic cation transmembrane transporter activity |
| GO:0036477 | 0.0173144759806 | 1.0 | HCN3 HCN1 HCN4 HCN2 | somatodendritic compartment |
| GO:0008324 | 0.0202159896681 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic cation transmembrane transporter activity |
| GO:0070305 | 0.0280843539964 | 0.5 | HCN4 HCN2 | response to cGMP |
| GO:0071321 | 0.0280843539964 | 0.5 | HCN4 HCN2 | cellular response to cGMP |
| GO:0098797 | 0.0296421612139 | 1.0 | HCN3 HCN1 HCN4 HCN2 | plasma membrane protein complex |
| GO:0098662 | 0.0299356479586 | 1.0 | HCN3 HCN1 HCN4 HCN2 | inorganic cation transmembrane transport |
| GO:0015318 | 0.0305291540849 | 1.0 | HCN3 HCN1 HCN4 HCN2 | inorganic molecular entity transmembrane transporter activity |
| KEGG:04024 | 0.0306683825257 | 0.5 | HCN4 HCN2 | cAMP signaling pathway |
| GO:0098655 | 0.0311314419202 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic cation transmembrane transport |
| GO:0099094 | 0.0378152735667 | 0.75 | HCN1 HCN4 HCN2 | ligand-gated monoatomic cation channel activity |
| HP:0020219 | 0.0400888551418 | 0.75 | HCN1 HCN4 HCN2 | Motor seizure |
| GO:0015075 | 0.0409056153775 | 1.0 | HCN3 HCN1 HCN4 HCN2 | monoatomic ion transmembrane transporter activity |
| GO:0098660 | 0.0416553027564 | 1.0 | HCN3 HCN1 HCN4 HCN2 | inorganic ion transmembrane transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HCN4 | HCN1 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HCN4 | HCN2 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HCN4 | HCN3 | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HCN2 | HCN3 | 0.391 | bioplex3_WMM WMM_only |
Related Complexes