hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03029.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS25 | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) | 5 | UniProt NCBI |
| SNF8 | Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22) | 5 | UniProt NCBI |
| VPS36 | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1187 | 2.33868713081e-10 | 1.0 | VPS36 VPS25 SNF8 | ESCRT-II complex |
| GO:0000814 | 9.61200410764e-08 | 1.0 | VPS36 VPS25 SNF8 | ESCRT II complex |
| REAC:R-HSA-917729 | 1.89440469306e-06 | 1.0 | VPS36 VPS25 SNF8 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0043328 | 5.38272230028e-05 | 1.0 | VPS36 VPS25 SNF8 | protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| REAC:R-HSA-9610379 | 7.31860792369e-05 | 1.0 | VPS36 VPS25 SNF8 | HCMV Late Events |
| KEGG:04144 | 0.000105930292769 | 1.0 | VPS36 VPS25 SNF8 | Endocytosis |
| GO:0032511 | 0.000148024863258 | 1.0 | VPS36 VPS25 SNF8 | late endosome to vacuole transport via multivesicular body sorting pathway |
| REAC:R-HSA-9609646 | 0.000217987188301 | 1.0 | VPS36 VPS25 SNF8 | HCMV Infection |
| GO:0036452 | 0.000221076094476 | 1.0 | VPS36 VPS25 SNF8 | ESCRT complex |
| GO:0036258 | 0.000432059584639 | 1.0 | VPS36 VPS25 SNF8 | multivesicular body assembly |
| GO:0045324 | 0.000432059584639 | 1.0 | VPS36 VPS25 SNF8 | late endosome to vacuole transport |
| GO:0036257 | 0.000476755403739 | 1.0 | VPS36 VPS25 SNF8 | multivesicular body organization |
| GO:0043162 | 0.000524430944113 | 1.0 | VPS36 VPS25 SNF8 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0032509 | 0.000575182325801 | 1.0 | VPS36 VPS25 SNF8 | endosome transport via multivesicular body sorting pathway |
| GO:0071985 | 0.000949666005835 | 1.0 | VPS36 VPS25 SNF8 | multivesicular body sorting pathway |
| GO:0090148 | 0.00102463963787 | 1.0 | VPS36 VPS25 SNF8 | membrane fission |
| GO:0072666 | 0.00225170808226 | 1.0 | VPS36 VPS25 SNF8 | establishment of protein localization to vacuole |
| GO:0072665 | 0.00649050577369 | 1.0 | VPS36 VPS25 SNF8 | protein localization to vacuole |
| GO:0007032 | 0.00820096190464 | 1.0 | VPS36 VPS25 SNF8 | endosome organization |
| REAC:R-HSA-199991 | 0.0145539954891 | 1.0 | VPS36 VPS25 SNF8 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.017135828319 | 1.0 | VPS36 VPS25 SNF8 | Vesicle-mediated transport |
| REAC:R-HSA-9824446 | 0.0269033233908 | 1.0 | VPS36 VPS25 SNF8 | Viral Infection Pathways |
| GO:0007034 | 0.0360123345897 | 1.0 | VPS36 VPS25 SNF8 | vacuolar transport |
| REAC:R-HSA-5663205 | 0.0499835710674 | 1.0 | VPS36 VPS25 SNF8 | Infectious disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS25 | VPS36 | 1.0 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction |
| SNF8 | VPS36 | 1.0 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () fraction |
| VPS25 | SNF8 | 1.0 | 0.822 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| VPS25 | huMAP3_03029.1 huMAP3_12909.1 |
| SNF8 | huMAP3_03029.1 huMAP3_12523.1 huMAP3_12909.1 |
| VPS36 | huMAP3_03029.1 huMAP3_12909.1 |