hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03067.1
Complex Portal: CPX-20644
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH3GL1 | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | 5 | UniProt NCBI |
| SH3GL2 | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | 5 | UniProt NCBI |
| PRR5-ARHGAP8 | PRR5-ARHGAP8 readthrough | 2 | UniProt NCBI |
| SH3GL3 | Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) | 5 | UniProt NCBI |
| ARHGAP8 | Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8875360 | 1.13468173222e-06 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 3.01907146066e-06 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 3.55148388129e-06 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 9.10580767182e-06 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | EGFR downregulation |
| GO:0016191 | 1.92180881975e-05 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | synaptic vesicle uncoating |
| GO:0072318 | 3.362820138e-05 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | clathrin coat disassembly |
| REAC:R-HSA-177929 | 4.1157848778e-05 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Signaling by EGFR |
| GO:0072319 | 5.37995977657e-05 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | vesicle uncoating |
| REAC:R-HSA-9824439 | 0.000100871107769 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Bacterial Infection Pathways |
| REAC:R-HSA-6806834 | 0.00016240432487 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Signaling by MET |
| REAC:R-HSA-8856825 | 0.000414423725659 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 0.00120721178545 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.00184833104877 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Endocytosis |
| GO:0048488 | 0.0135806930791 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | synaptic vesicle endocytosis |
| GO:0140238 | 0.0135806930791 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | presynaptic endocytosis |
| GO:0036465 | 0.0237169649094 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | synaptic vesicle recycling |
| WP:WP4549 | 0.0347437372246 | 0.4 | SH3GL1 SH3GL3 | Fragile X syndrome |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | Signaling by Receptor Tyrosine Kinases |
| GO:0098978 | 0.0457443058639 | 0.6 | SH3GL1 SH3GL2 SH3GL3 | glutamatergic synapse |
| CORUM:2029 | 0.0498708842806 | 0.2 | ARHGAP8 | BNIP2-ARHGAP8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SH3GL1 | SH3GL3 | 1.0 | 0.194 |
mutually_exclusive (Q99962)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SH3GL2 | SH3GL3 | 1.0 | 0.206 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SH3GL1 | SH3GL2 | 1.0 | 0.144 |
mutually_exclusive (Q99963)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SH3GL3 | ARHGAP8 | 0.839 | bioplex () bioplex_WMM bioplex3_WMM | ||
| SH3GL2 | ARHGAP8 | 0.763 | bioplex () bioplex_WMM bioplex3_WMM | ||
| SH3GL1 | ARHGAP8 | 0.485 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| SH3GL1 | huMAP3_03067.1 huMAP3_14074.1 |
| SH3GL2 | huMAP3_03067.1 huMAP3_14074.1 |
| PRR5-ARHGAP8 | huMAP3_03067.1 huMAP3_06394.1 huMAP3_14074.1 |
| SH3GL3 | huMAP3_03067.1 huMAP3_14074.1 |
| ARHGAP8 | huMAP3_03067.1 huMAP3_14074.1 |