hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03070.1
Complex Portal: CPX-25084
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | 5 | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | 5 | UniProt NCBI |
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 1.21479847542e-09 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | Signaling by BMP |
| KEGG:04350 | 5.22938873215e-08 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | TGF-beta signaling pathway |
| REAC:R-HSA-9006936 | 5.14641931672e-07 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | Signaling by TGFB family members |
| GO:0046332 | 9.66436624335e-06 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | SMAD binding |
| GO:0030509 | 6.42456040004e-05 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | BMP signaling pathway |
| GO:0071772 | 7.35215694974e-05 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | response to BMP |
| GO:0071773 | 7.35215694974e-05 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | cellular response to BMP stimulus |
| WP:WP3876 | 0.000114838123418 | 0.5 | SMAD1 SMAD5 | BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation |
| WP:WP1425 | 0.000114838123418 | 0.5 | SMAD1 SMURF1 | Bone morphogenic protein signaling and regulation |
| GO:0070411 | 0.000174830724535 | 0.75 | SMAD5 SMAD1 SMURF1 | I-SMAD binding |
| WP:WP3927 | 0.000346844620397 | 0.5 | SMAD1 SMAD5 | BMP signaling in eyelid development |
| GO:0007179 | 0.000518885109813 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | transforming growth factor beta receptor signaling pathway |
| WP:WP2895 | 0.000535373329556 | 0.5 | SMAD1 SMAD5 | Differentiation of white and brown adipocyte |
| GO:0071560 | 0.000883719448116 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | cellular response to transforming growth factor beta stimulus |
| GO:0071559 | 0.000993378785041 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | response to transforming growth factor beta |
| WP:WP4331 | 0.00126323103486 | 0.5 | SMAD1 SMAD5 | Neovascularisation processes |
| WP:WP4249 | 0.00169541860832 | 0.5 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| WP:WP560 | 0.0022974831852 | 0.5 | SMAD1 SMAD5 | TGF beta receptor signaling |
| KEGG:04340 | 0.00247340401034 | 0.5 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| WP:WP4816 | 0.00251837499235 | 0.5 | SMAD1 SMAD5 | TGF beta receptor signaling in skeletal dysplasias |
| GO:0141091 | 0.00254488754804 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | transforming growth factor beta receptor superfamily signaling pathway |
| REAC:R-HSA-2173788 | 0.00258893271292 | 0.5 | SMURF2 SMURF1 | Downregulation of TGF-beta receptor signaling |
| WP:WP5352 | 0.0027493593259 | 0.5 | SMAD1 SMAD5 | 10q11 21q11 23 copy number variation syndrome |
| WP:WP5236 | 0.0027493593259 | 0.5 | SMAD1 SMAD5 | Markers of kidney cell lineage |
| GO:0007178 | 0.00314873966928 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| WP:WP5094 | 0.00561306746582 | 0.5 | SMAD1 SMAD5 | Orexin receptor pathway |
| WP:WP5205 | 0.00578263137464 | 0.5 | SMAD1 SMAD5 | Clock controlled autophagy in bone metabolism |
| WP:WP5353 | 0.00685264055756 | 0.5 | SMAD1 SMAD5 | A network map of Macrophage stimulating protein MSP signaling |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | SMURF2 SMURF1 | TGF-beta receptor signaling activates SMADs |
| KEGG:04520 | 0.00909742323246 | 0.5 | SMURF2 SMURF1 | Adherens junction |
| KEGG:04137 | 0.0118173906169 | 0.5 | SMURF2 SMURF1 | Mitophagy - animal |
| WP:WP3931 | 0.0125286636678 | 0.5 | SMAD1 SMAD5 | Embryonic stem cell pluripotency pathways |
| WP:WP4787 | 0.0130350149263 | 0.5 | SMAD1 SMAD5 | Osteoblast differentiation and related diseases |
| REAC:R-HSA-8941858 | 0.0146019089592 | 0.5 | SMURF2 SMURF1 | Regulation of RUNX3 expression and activity |
| KEGG:04550 | 0.0177164397058 | 0.5 | SMAD1 SMAD5 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP366 | 0.0177395403747 | 0.5 | SMURF2 SMURF1 | TGF beta signaling pathway |
| REAC:R-HSA-4608870 | 0.0199119958937 | 0.5 | SMURF2 SMURF1 | Asymmetric localization of PCP proteins |
| KEGG:04120 | 0.0224124539322 | 0.5 | SMURF2 SMURF1 | Ubiquitin mediated proteolysis |
| GO:0071363 | 0.0296421612139 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | cellular response to growth factor stimulus |
| REAC:R-HSA-5632684 | 0.0297941212351 | 0.5 | SMURF2 SMURF1 | Hedgehog 'on' state |
| GO:0070848 | 0.0339527319479 | 1.0 | SMURF2 SMAD5 SMAD1 SMURF1 | response to growth factor |
| WP:WP5115 | 0.0365498826325 | 0.5 | SMAD1 SMAD5 | Network map of SARS CoV 2 signaling pathway |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | SMURF2 SMURF1 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-8878159 | 0.0389395459224 | 0.5 | SMURF2 SMURF1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-4086400 | 0.041644107744 | 0.5 | SMURF2 SMURF1 | PCP/CE pathway |
| GO:0017151 | 0.042122686785 | 0.5 | SMAD1 SMAD5 | DEAD/H-box RNA helicase binding |
| CORUM:2996 | 0.049938562206 | 0.25 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| CORUM:2992 | 0.049938562206 | 0.25 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2958 | 0.049938562206 | 0.25 | SMAD1 | SMAD1-CBP complex |
| CORUM:2642 | 0.049938562206 | 0.25 | SMAD1 | SMAD1-P300 complex |
| CORUM:3972 | 0.049938562206 | 0.25 | SMURF2 | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMAD5 | SMURF2 | 0.974 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMURF2 | SMURF1 | 0.969 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMAD1 | SMURF2 | 0.966 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMAD1 | SMURF1 | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD5 | SMURF1 | 0.32 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD5 | SMAD1 | 0.3 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes