hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03088.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EGFLAM | Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) | 5 | UniProt NCBI |
| PDCD4 | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | 5 | UniProt NCBI |
| FOXN2 | Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor) | 4 | UniProt NCBI |
| CDC25B | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | 5 | UniProt NCBI |
| ZNF704 | Zinc finger protein 704 | 3 | UniProt NCBI |
| STARD8 | StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) | 5 | UniProt NCBI |
| CDC25A | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | 5 | UniProt NCBI |
| USP37 | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | 5 | UniProt NCBI |
| HIVEP2 | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | 5 | UniProt NCBI |
| INKA1 | PAK4-inhibitor INKA1 (Induced in neural crest by AP2-alpha protein homolog) (Inca) (Inka-box actin regulator 1) | 5 | UniProt NCBI |
| USP47 | Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) | 5 | UniProt NCBI |
| BTRC | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | 5 | UniProt NCBI |
| UBE2R2 | Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) | 5 | UniProt NCBI |
| TFAP4 | Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) | 5 | UniProt NCBI |
| CDC34 | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) | 5 | UniProt NCBI |
| SPANXN3 | Sperm protein associated with the nucleus on the X chromosome N3 (Nuclear-associated protein SPAN-Xn3) (SPANX-N3) (SPANX family member N3) | 4 | UniProt NCBI |
| TRPV6 | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | 5 | UniProt NCBI |
| BHLHE40 | Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04120 | 0.0184337566966 | 0.2 | BTRC UBE2R2 CDC34 | Ubiquitin mediated proteolysis |
| KEGG:04710 | 0.0239827597744 | 0.133333333333 | BTRC BHLHE40 | Circadian rhythm |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| UBE2R2 | CDC34 | 0.999 | 0.186 |
| TFAP4 | BTRC | 0.999 | 0.216 |
| BTRC | USP47 | 0.999 | |
| BTRC | ZNF704 | 0.997 | |
| BTRC | CDC34 | 0.995 | 0.122 |
| BTRC | BHLHE40 | 0.994 | |
| BTRC | CDC25A | 0.993 | |
| BTRC | HIVEP2 | 0.992 | 0.074 |
| USP37 | BTRC | 0.992 | 0.25 |
| BTRC | CDC25B | 0.991 | 0.22 |
| SPANXN3 | BTRC | 0.987 | |
| BTRC | TRPV6 | 0.977 | |
| BTRC | FOXN2 | 0.975 | |
| PDCD4 | BTRC | 0.973 | 0.142 |
| BTRC | UBE2R2 | 0.971 | 0.152 |
| BTRC | STARD8 | 0.968 | 0.132 |
| BTRC | INKA1 | 0.966 | |
| BTRC | EGFLAM | 0.963 | |
| HIVEP2 | CDC25B | 0.863 | 0.086 |
| TFAP4 | HIVEP2 | 0.837 | 0.1 |
| TFAP4 | BHLHE40 | 0.817 | |
| USP37 | BHLHE40 | 0.814 | |
| HIVEP2 | BHLHE40 | 0.806 | |
| USP37 | CDC34 | 0.782 | 0.092 |
| TFAP4 | USP37 | 0.776 | 0.162 |
| TFAP4 | CDC34 | 0.768 | 0.058 |
| PDCD4 | BHLHE40 | 0.768 | |
| HIVEP2 | CDC34 | 0.768 | 0.036 |
| BHLHE40 | CDC34 | 0.768 | |
| BHLHE40 | CDC25B | 0.768 | |
| PDCD4 | HIVEP2 | 0.763 | 0.072 |
| PDCD4 | CDC34 | 0.763 | 0.098 |
| USP37 | PDCD4 | 0.746 | 0.066 |
| USP47 | CDC34 | 0.707 | |
| TFAP4 | USP47 | 0.707 | |
| USP37 | HIVEP2 | 0.685 | 0.108 |
| CDC25B | USP47 | 0.678 | |
| USP37 | CDC25B | 0.675 | 0.136 |
| TFAP4 | PDCD4 | 0.663 | 0.096 |
| CDC25B | CDC34 | 0.658 | 0.046 |
| TFAP4 | CDC25B | 0.658 | 0.132 |
| PDCD4 | CDC25B | 0.651 | 0.118 |
| PDCD4 | USP47 | 0.63 | |
| BHLHE40 | USP47 | 0.589 | |
| USP37 | TRPV6 | 0.572 | |
| EGFLAM | TRPV6 | 0.572 | |
| USP37 | USP47 | 0.561 | |
| TRPV6 | BHLHE40 | 0.557 | |
| TRPV6 | CDC25A | 0.502 | |
| TFAP4 | TRPV6 | 0.502 | |
| PDCD4 | TRPV6 | 0.502 | |
| TRPV6 | CDC34 | 0.502 | |
| HIVEP2 | USP47 | 0.489 | |
| CDC25B | CDC25A | 0.475 | |
| TRPV6 | CDC25B | 0.35 | |
| HIVEP2 | TRPV6 | 0.35 | |
| USP37 | EGFLAM | 0.333 | |
| USP37 | CDC25A | 0.333 | |
| HIVEP2 | CDC25A | 0.304 | |
| EGFLAM | BHLHE40 | 0.303 | |
| EGFLAM | USP47 | 0.214 | |
| EGFLAM | CDC25A | 0.172 | |
| BHLHE40 | CDC25A | 0.172 | |
| TFAP4 | EGFLAM | 0.164 | |
| PDCD4 | CDC25A | 0.164 | |
| HIVEP2 | EGFLAM | 0.164 | |
| PDCD4 | EGFLAM | 0.164 | |
| CDC25A | CDC34 | 0.164 | |
| EGFLAM | CDC25B | 0.164 | |
| EGFLAM | CDC34 | 0.164 | |
| TFAP4 | CDC25A | 0.164 | |
| CDC25A | USP47 | 0.144 | |
| TRPV6 | USP47 | 0.143 | |
| TRPV6 | UBE2R2 | 0.11 | |
| CDC25B | UBE2R2 | 0.11 | 0.064 |
| BHLHE40 | UBE2R2 | 0.11 | |
| TFAP4 | UBE2R2 | 0.11 | 0.052 |
| HIVEP2 | UBE2R2 | 0.11 | 0.014 |
| CDC25A | UBE2R2 | 0.11 | |
| USP37 | UBE2R2 | 0.11 | 0.052 |
| EGFLAM | UBE2R2 | 0.11 | |
| USP47 | UBE2R2 | 0.099 | |
| PDCD4 | UBE2R2 | 0.095 | 0.044 |
Related Complexes