hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03089.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NLGN3 | Neuroligin-3 (Gliotactin homolog) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| NLGN4X | Neuroligin-4, X-linked (Neuroligin X) (HNLX) | 5 | UniProt NCBI |
| NLGN1 | Neuroligin-1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0098985 | 2.63126310092e-11 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | asymmetric, glutamatergic, excitatory synapse |
| GO:0097104 | 3.94689465137e-10 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | postsynaptic membrane assembly |
| GO:0097105 | 1.84188417064e-09 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | presynaptic membrane assembly |
| GO:0097090 | 3.31539150715e-09 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | presynaptic membrane organization |
| GO:0060077 | 3.31539150715e-09 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | inhibitory synapse |
| GO:0007158 | 5.52565251192e-09 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | neuron cell-cell adhesion |
| GO:0042043 | 1.30247523495e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | neurexin family protein binding |
| GO:0099068 | 1.30247523495e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | postsynapse assembly |
| REAC:R-HSA-6794361 | 1.5670900333e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | Neurexins and neuroligins |
| GO:0098982 | 2.63389436402e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | GABA-ergic synapse |
| GO:0001941 | 3.59167413275e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | postsynaptic membrane organization |
| GO:0060076 | 8.0516650888e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | excitatory synapse |
| REAC:R-HSA-6794362 | 8.80508022231e-08 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | Protein-protein interactions at synapses |
| KEGG:04514 | 1.08025707832e-07 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | Cell adhesion molecules |
| WP:WP5398 | 1.2715614816e-07 | 0.75 | NLGN3 NLGN4X NLGN1 | NRXN1 deletion syndrome |
| GO:0099054 | 2.32998347586e-07 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | presynapse assembly |
| GO:0099172 | 2.79598017103e-07 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | presynapse organization |
| WP:WP4875 | 8.03005285051e-07 | 0.75 | NLGN3 NLGN4X NLGN1 | Disruption of postsynaptic signaling by CNV |
| GO:0098983 | 1.53784171933e-06 | 0.75 | NLGN3 NLGN4X NLGN4Y | symmetric, GABA-ergic, inhibitory synapse |
| GO:0140238 | 3.92045045721e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | presynaptic endocytosis |
| GO:0048488 | 3.92045045721e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synaptic vesicle endocytosis |
| GO:0097110 | 4.69325242995e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | scaffold protein binding |
| GO:0071709 | 5.5750150077e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | membrane assembly |
| GO:0044091 | 7.12348702995e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | membrane biogenesis |
| GO:0032280 | 7.68841921772e-06 | 0.75 | NLGN3 NLGN4X NLGN4Y | symmetric synapse |
| GO:0036465 | 8.32139586928e-06 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synaptic vesicle recycling |
| GO:0098978 | 2.01681054159e-05 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | glutamatergic synapse |
| GO:0071625 | 2.15253635486e-05 | 0.75 | NLGN3 NLGN4X NLGN4Y | vocalization behavior |
| REAC:R-HSA-112316 | 3.09235191422e-05 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | Neuronal System |
| GO:0099173 | 3.75329946872e-05 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | postsynapse organization |
| GO:0007416 | 8.74095077072e-05 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synapse assembly |
| GO:0099504 | 0.000125780428129 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synaptic vesicle cycle |
| GO:0099003 | 0.000141011889278 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | vesicle-mediated transport in synapse |
| HP:5200104 | 0.000200620835246 | 0.5 | NLGN3 NLGN4X | Abnormal play |
| HP:0000721 | 0.000200620835246 | 0.5 | NLGN3 NLGN4X | Lack of spontaneous play |
| GO:0032279 | 0.000208942050999 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | asymmetric synapse |
| GO:0098984 | 0.000246845395967 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | neuron to neuron synapse |
| GO:0035176 | 0.000372255315939 | 0.75 | NLGN3 NLGN4X NLGN4Y | social behavior |
| HP:5200130 | 0.000501460556964 | 0.5 | NLGN3 NLGN4X | Insistence on sameness |
| HP:0000732 | 0.000501460556964 | 0.5 | NLGN3 NLGN4X | Inflexible adherence to routines |
| GO:0051703 | 0.000510886175237 | 0.75 | NLGN3 NLGN4X NLGN4Y | biological process involved in intraspecies interaction between organisms |
| GO:0098815 | 0.000680215375943 | 0.75 | NLGN3 NLGN4X NLGN1 | modulation of excitatory postsynaptic potential |
| HP:5200016 | 0.000701980712879 | 0.5 | NLGN3 NLGN4X | Abnormal peer relationships |
| HP:0002332 | 0.000701980712879 | 0.5 | NLGN3 NLGN4X | Lack of peer relationships |
| WP:WP5420 | 0.00101030857977 | 0.75 | NLGN3 NLGN4X NLGN1 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0007610 | 0.00121610733906 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | behavior |
| GO:0050804 | 0.00160144369006 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | modulation of chemical synaptic transmission |
| GO:0099177 | 0.00163446314759 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | regulation of trans-synaptic signaling |
| GO:0060079 | 0.00209449363787 | 0.75 | NLGN3 NLGN4X NLGN1 | excitatory postsynaptic potential |
| HP:0003144 | 0.00220521848756 | 0.5 | NLGN3 NLGN4X | Increased serum serotonin |
| GO:0050808 | 0.00254488754804 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synapse organization |
| HP:5200024 | 0.00260592941411 | 0.5 | NLGN3 NLGN4X | Abnormal relationship |
| GO:0099565 | 0.00298219742351 | 0.75 | NLGN3 NLGN4X NLGN1 | chemical synaptic transmission, postsynaptic |
| HP:0000723 | 0.00400802433742 | 0.5 | NLGN3 NLGN4X | Restrictive behavior |
| GO:0007612 | 0.00409056451107 | 0.75 | NLGN3 NLGN4X NLGN4Y | learning |
| GO:0060078 | 0.00473512798232 | 0.75 | NLGN3 NLGN4X NLGN1 | regulation of postsynaptic membrane potential |
| GO:0034329 | 0.00553001869835 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | cell junction assembly |
| GO:0031644 | 0.00951168180783 | 0.75 | NLGN3 NLGN4X NLGN1 | regulation of nervous system process |
| GO:0098916 | 0.016735764789 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | anterograde trans-synaptic signaling |
| GO:0007268 | 0.016735764789 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | chemical synaptic transmission |
| GO:0099537 | 0.0175106740088 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | trans-synaptic signaling |
| GO:0099536 | 0.0220295332932 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | synaptic signaling |
| CORUM:7344 | 0.0249718442456 | 0.25 | NLGN1 | NLGN1-NRXN1 complex |
| GO:0034330 | 0.0329918597872 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | cell junction organization |
| GO:0007611 | 0.0449670283878 | 0.75 | NLGN3 NLGN4X NLGN4Y | learning or memory |
| GO:0006897 | 0.0467824894143 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | endocytosis |
| GO:0050877 | 0.0471955798286 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | nervous system process |
| GO:0050839 | 0.0476113999152 | 1.0 | NLGN3 NLGN1 NLGN4X NLGN4Y | cell adhesion molecule binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NLGN4Y | NLGN3 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | NLGN1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN3 | NLGN4X | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NLGN4Y | NLGN4X | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| NLGN4X | NLGN1 | 0.543 | bioplex_WMM bioplex3_WMM WMM_only | |
| NLGN4Y | NLGN1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes