hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03095.1
Complex Portal: CPX-25277
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SYNRG | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | 5 | UniProt NCBI |
| KIF13A | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | 5 | UniProt NCBI |
| HEATR5B | HEAT repeat-containing protein 5B | 5 | UniProt NCBI |
| AP1G2 | AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) | 5 | UniProt NCBI |
| AFTPH | Aftiphilin | 5 | UniProt NCBI |
| AP1M2 | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | 5 | UniProt NCBI |
| MEA1 | Male-enhanced antigen 1 (MEA-1) | 3 | UniProt NCBI |
| AP1S3 | AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin) | 5 | UniProt NCBI |
| AP1S2 | AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) | 5 | UniProt NCBI |
| AP1AR | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030121 | 1.62924420516e-13 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | AP-1 adaptor complex |
| CORUM:144 | 4.16907122432e-13 | 0.5 | AP1M2 AP1AR AP1G2 AP1S2 AP1S3 | Gamma-BAR-AP1 complex |
| GO:0030130 | 7.16530924676e-13 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin coat of trans-Golgi network vesicle |
| GO:0012510 | 2.32763219017e-12 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | trans-Golgi network transport vesicle membrane |
| GO:0030131 | 1.43754889331e-11 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin adaptor complex |
| GO:0030140 | 2.91053289042e-10 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | trans-Golgi network transport vesicle |
| GO:0030125 | 3.66894003456e-10 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin vesicle coat |
| CORUM:36 | 5.63923523184e-10 | 0.4 | AP1M2 AP1G2 AP1S2 AP1S3 | AP1 adaptor complex |
| GO:0030119 | 1.25192287374e-09 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | AP-type membrane coat adaptor complex |
| GO:0030118 | 2.51405460706e-09 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin coat |
| GO:0030660 | 6.26742705426e-09 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | Golgi-associated vesicle membrane |
| GO:0030120 | 2.78442044942e-08 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | vesicle coat |
| GO:0005798 | 9.17232207211e-08 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | Golgi-associated vesicle |
| GO:0030117 | 3.84746777847e-07 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | membrane coat |
| GO:0048475 | 3.84746777847e-07 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | coated membrane |
| GO:0030665 | 5.42648709152e-07 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin-coated vesicle membrane |
| REAC:R-HSA-432720 | 1.081952275e-06 | 0.4 | AP1M2 AP1G2 AP1S2 AP1S3 | Lysosome Vesicle Biogenesis |
| GO:0030658 | 2.12967255275e-06 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | transport vesicle membrane |
| GO:0030133 | 2.39454320468e-06 | 0.7 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1AR AP1S3 | transport vesicle |
| REAC:R-HSA-164940 | 6.66981091631e-06 | 0.3 | AP1M2 AP1S3 AP1S2 | Nef mediated downregulation of MHC class I complex cell surface expression |
| GO:0030136 | 8.37665369569e-06 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | clathrin-coated vesicle |
| GO:0030662 | 9.49376861115e-06 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | coated vesicle membrane |
| REAC:R-HSA-199992 | 2.39497785462e-05 | 0.4 | AP1M2 AP1G2 AP1S2 AP1S3 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 4.85769358756e-05 | 0.4 | AP1M2 AP1G2 AP1S2 AP1S3 | Lysosome |
| REAC:R-HSA-164938 | 7.36319907643e-05 | 0.3 | AP1M2 AP1S3 AP1S2 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| GO:0032588 | 0.000102961120901 | 0.5 | AP1M2 KIF13A AP1S3 AP1S2 AFTPH | trans-Golgi network membrane |
| GO:0030135 | 0.000117750582977 | 0.6 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1S3 | coated vesicle |
| REAC:R-HSA-164952 | 0.000161586017522 | 0.3 | AP1M2 AP1S3 AP1S2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| KEGG:05170 | 0.000292946666588 | 0.4 | AP1M2 AP1G2 AP1S2 AP1S3 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-432722 | 0.00135700365651 | 0.3 | AP1M2 AP1S3 AP1S2 | Golgi Associated Vesicle Biogenesis |
| GO:0031410 | 0.00137129474097 | 0.9 | AP1S2 HEATR5B AP1M2 SYNRG AP1S3 AFTPH AP1AR KIF13A AP1G2 | cytoplasmic vesicle |
| GO:0097708 | 0.00139355619292 | 0.9 | AP1S2 HEATR5B AP1M2 SYNRG AP1S3 AFTPH AP1AR KIF13A AP1G2 | intracellular vesicle |
| GO:0005794 | 0.00240439645893 | 0.8 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH AP1AR KIF13A AP1S3 | Golgi apparatus |
| GO:0030659 | 0.00482091360928 | 0.7 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH KIF13A AP1S3 | cytoplasmic vesicle membrane |
| GO:0012506 | 0.00537693251814 | 0.7 | AP1S2 AP1M2 SYNRG AP1G2 AFTPH KIF13A AP1S3 | vesicle membrane |
| GO:0005802 | 0.00817366085861 | 0.5 | AP1M2 KIF13A AP1S3 AP1S2 AFTPH | trans-Golgi network |
| REAC:R-HSA-2132295 | 0.0139121018372 | 0.3 | AP1M2 AP1S3 AP1S2 | MHC class II antigen presentation |
| REAC:R-HSA-162909 | 0.0169447369121 | 0.3 | AP1M2 AP1S3 AP1S2 | Host Interactions of HIV factors |
| GO:0098791 | 0.0182422070876 | 0.5 | AP1M2 KIF13A AP1S3 AP1S2 AFTPH | Golgi apparatus subcompartment |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP1S2 | AP1G2 | 1.0 | 0.104 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| AP1S2 | HEATR5B | 1.0 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| AP1G2 | AP1M2 | 0.999 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AP1S2 | AP1AR | 0.999 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| AP1S2 | AFTPH | 0.999 | 0.072 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| AP1S2 | SYNRG | 0.999 | 0.152 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| SYNRG | AFTPH | 0.999 | 0.126 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| HEATR5B | AP1S3 | 0.999 | 0.032 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 bioplex_WMM WMM_only | |
| AP1M2 | AP1S3 | 0.999 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AP1S2 | AP1M2 | 0.999 | 0.174 |
mutually_exclusive (O75843)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AFTPH | AP1S3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP1M2 | MEA1 | 0.998 | 0.068 |
mutually_exclusive (Q9BXS5)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KIF13A | AP1S3 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SYNRG | AP1S3 | 0.997 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HEATR5B | AFTPH | 0.995 | 0.326 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| AP1AR | AP1S3 | 0.994 | 0.096 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP1S2 | MEA1 | 0.992 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP1G2 | AP1S3 | 0.991 | 0.046 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SYNRG | HEATR5B | 0.991 | 0.125 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| HEATR5B | AP1G2 | 0.99 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| AP1S2 | AP1S3 | 0.99 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF13A | AP1M2 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| AP1G2 | AFTPH | 0.979 | 0.06 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MEA1 | AP1S3 | 0.978 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEATR5B | AP1M2 | 0.953 | 0.086 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM | |
| AFTPH | AP1M2 | 0.951 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SYNRG | AP1M2 | 0.951 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SYNRG | AP1G2 | 0.947 | 0.222 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AP1G2 | MEA1 | 0.946 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP1AR | SYNRG | 0.933 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| AP1AR | AFTPH | 0.918 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| AP1AR | HEATR5B | 0.905 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| AP1AR | AP1G2 | 0.893 | 0.06 |
structurally_consistent (O43747)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| AP1S2 | KIF13A | 0.839 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AFTPH | MEA1 | 0.822 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF13A | HEATR5B | 0.795 | bioplex3_WMM WMM_only | ||
| SYNRG | KIF13A | 0.795 | bioplex3_WMM WMM_only | ||
| KIF13A | AFTPH | 0.795 | bioplex3_WMM WMM_only | ||
| KIF13A | AP1G2 | 0.783 | bioplex3_WMM WMM_only bioplex_WMM | ||
| HEATR5B | MEA1 | 0.777 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF13A | MEA1 | 0.726 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYNRG | MEA1 | 0.578 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| AP1AR | KIF13A | 0.49 | bioplex3_WMM WMM_only | ||
| AP1AR | AP1M2 | 0.402 | 0.05 |
mutually_exclusive (Q9BXS5)
|
bioplex3_WMM WMM_only |
| AP1AR | MEA1 | 0.178 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes