hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03100.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRIPTO | Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1) | 5 | UniProt NCBI |
| SKI | Ski oncogene (Proto-oncogene c-Ski) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| SPON1 | Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) | 5 | UniProt NCBI |
| GID8 | Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) | 5 | UniProt NCBI |
| RANBP9 | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | 5 | UniProt NCBI |
| HBP1 | HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) | 5 | UniProt NCBI |
| GDF15 | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | 5 | UniProt NCBI |
| PRG3 | Proteoglycan 3 (Eosinophil major basic protein homolog) (Prepro-major basic protein homolog) (Prepro-MBPH) | 5 | UniProt NCBI |
| RMND5A | E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A) | 5 | UniProt NCBI |
| INSL6 | Insulin-like peptide INSL6 (Insulin-like peptide 6) (Relaxin/insulin-like factor 1) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain] | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:639 | 0.000164069436391 | 0.222222222222 | GID8 RANBP9 | RANBPM-Muskelin-TWA1-HSMpp8 complex |
| CORUM:3071 | 0.000273361732609 | 0.222222222222 | RANBP9 RMND5A | CTLH complex |
| WP:WP4352 | 0.00044167157014 | 0.444444444444 | GID8 RMND5A HTRA2 RANBP9 | Ciliary landscape |
| WP:WP5381 | 0.00632141732043 | 0.333333333333 | RMND5A RANBP9 HBP1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| CORUM:641 | 0.0499842271994 | 0.111111111111 | RANBP9 | RANBPM-SMP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RANBP9 | RMND5A | 1.0 | 0.272 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| GID8 | RANBP9 | 1.0 | 0.264 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| HTRA2 | RMND5A | 0.999 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| GID8 | RMND5A | 0.999 | 0.482 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| RMND5A | INSL6 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SKI | RMND5A | 0.996 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PRG3 | RMND5A | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GID8 | HBP1 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RANBP9 | PRG3 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HTRA2 | GID8 | 0.993 | 0.066 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| GID8 | PRG3 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HBP1 | RMND5A | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CRIPTO | RMND5A | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RANBP9 | INSL6 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SKI | GID8 | 0.988 | 0.106 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CRIPTO | GID8 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CRIPTO | RANBP9 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RANBP9 | GDF15 | 0.979 | 0.044 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPON1 | RANBP9 | 0.979 | 0.054 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HTRA2 | SKI | 0.976 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| GID8 | INSL6 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SPON1 | GID8 | 0.972 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GID8 | GDF15 | 0.969 | 0.036 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HTRA2 | RANBP9 | 0.967 | 0.05 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| GDF15 | RMND5A | 0.967 | 0.052 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPON1 | RMND5A | 0.964 | 0.064 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| HTRA2 | HBP1 | 0.948 | bioplex_WMM bioplex3_WMM WMM_only | |
| HTRA2 | GDF15 | 0.947 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RANBP9 | HBP1 | 0.87 | bioplex_WMM bioplex3_WMM WMM_only | |
| HTRA2 | INSL6 | 0.863 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GDF15 | PRG3 | 0.856 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SKI | RANBP9 | 0.832 | 0.096 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SKI | HBP1 | 0.777 | bioplex3_WMM WMM_only | |
| HBP1 | GDF15 | 0.663 | bioplex3_WMM WMM_only | |
| CRIPTO | HTRA2 | 0.354 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SKI | GDF15 | 0.305 | 0.086 | bioplex3_WMM WMM_only |
| HTRA2 | PRG3 | 0.294 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SPON1 | GDF15 | 0.038 | 0.056 | bioplex3_WMM WMM_only |
| CRIPTO | GDF15 | 0.027 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes