hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03127.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
| PABPC1L | Polyadenylate-binding protein 1-like | 3 | UniProt NCBI |
| MKRN2 | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03015 | 4.15157123412e-05 | 0.75 | ETF1 GSPT2 PABPC1L | mRNA surveillance pathway |
| WP:WP107 | 0.00299043061896 | 0.5 | ETF1 GSPT2 | Translation factors |
| GO:0018444 | 0.00842684400117 | 0.5 | ETF1 GSPT2 | translation release factor complex |
| CORUM:809 | 0.0249718442456 | 0.25 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
| REAC:R-HSA-72764 | 0.041644107744 | 0.5 | ETF1 GSPT2 | Eukaryotic Translation Termination |
| GO:0003747 | 0.042122686785 | 0.5 | ETF1 GSPT2 | translation release factor activity |
| GO:0008079 | 0.042122686785 | 0.5 | ETF1 GSPT2 | translation termination factor activity |
| REAC:R-HSA-975956 | 0.0444386798825 | 0.5 | ETF1 GSPT2 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GSPT2 | ETF1 | 0.987 | 0.686 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| MKRN2 | GSPT2 | 0.983 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MKRN2 | ETF1 | 0.025 | 0.13 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes