hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03145.1
Complex Portal: CPX-14915
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CLEC4G | C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin) | 5 | UniProt NCBI |
| AP4S1 | AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) | 5 | UniProt NCBI |
| TEPSIN | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | 5 | UniProt NCBI |
| AP4M1 | AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4) | 5 | UniProt NCBI |
| AP4E1 | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:67 | 1.12081835382e-08 | 0.6 | AP4E1 AP4S1 AP4M1 | AP4 adaptor complex |
| HP:5200020 | 1.5789202482e-06 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal interest in others |
| HP:0100962 | 1.5789202482e-06 | 0.6 | AP4E1 AP4S1 AP4M1 | Shyness |
| GO:0030124 | 3.84440695359e-06 | 0.6 | AP4E1 AP4S1 AP4M1 | AP-4 adaptor complex |
| HP:0008807 | 1.49843429512e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Acetabular dysplasia |
| REAC:R-HSA-432720 | 1.69745830215e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Lysosome Vesicle Biogenesis |
| HP:0002464 | 1.7479937387e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Spastic dysarthria |
| HP:0010803 | 2.02378479708e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Everted upper lip vermilion |
| HP:0007020 | 4.3024884775e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Progressive spastic paraplegia |
| HP:0002816 | 7.16187886385e-05 | 0.6 | AP4E1 AP4S1 AP4M1 | Genu recurvatum |
| HP:0025502 | 0.000101951828436 | 0.6 | AP4E1 AP4S1 AP4M1 | Overweight |
| HP:0002761 | 0.000101951828436 | 0.6 | AP4E1 AP4S1 AP4M1 | Generalized joint hypermobility |
| HP:0010500 | 0.000110679175074 | 0.6 | AP4E1 AP4S1 AP4M1 | Hyperextensibility of the knee |
| HP:0000297 | 0.000161829008877 | 0.6 | AP4E1 AP4S1 AP4M1 | Facial hypotonia |
| REAC:R-HSA-199992 | 0.000169658686915 | 0.6 | AP4E1 AP4S1 AP4M1 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 0.000278939673238 | 0.6 | AP4E1 AP4S1 AP4M1 | Lysosome |
| GO:0032588 | 0.000349949920328 | 0.8 | TEPSIN AP4S1 AP4E1 AP4M1 | trans-Golgi network membrane |
| HP:0003170 | 0.000918726168333 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal acetabulum morphology |
| HP:0034670 | 0.000955873343891 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal knee physiology |
| HP:0002307 | 0.00192267581507 | 0.6 | AP4E1 AP4S1 AP4M1 | Drooling |
| HP:0000646 | 0.00204495106592 | 0.6 | AP4E1 AP4S1 AP4M1 | Amblyopia |
| HP:0001258 | 0.0022378814793 | 0.6 | AP4E1 AP4S1 AP4M1 | Spastic paraplegia |
| HP:0003781 | 0.00244253615615 | 0.6 | AP4E1 AP4S1 AP4M1 | Excessive salivation |
| GO:0031904 | 0.00249322401434 | 0.6 | AP4E1 AP4S1 AP4M1 | endosome lumen |
| HP:0002515 | 0.00258565436429 | 0.6 | AP4E1 AP4S1 AP4M1 | Waddling gait |
| HP:0002518 | 0.00443745887352 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal periventricular white matter morphology |
| HP:0010550 | 0.00443745887352 | 0.6 | AP4E1 AP4S1 AP4M1 | Paraplegia |
| HP:0012433 | 0.00593647702079 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal social behavior |
| GO:0030119 | 0.00627040828674 | 0.6 | AP4E1 AP4S1 AP4M1 | AP-type membrane coat adaptor complex |
| HP:0100021 | 0.00659213000273 | 0.6 | AP4E1 AP4S1 AP4M1 | Cerebral palsy |
| HP:0000341 | 0.00744020362032 | 0.6 | AP4E1 AP4S1 AP4M1 | Narrow forehead |
| HP:0012472 | 0.0078900935851 | 0.6 | AP4E1 AP4S1 AP4M1 | Eclabion |
| HP:0100755 | 0.0105962255115 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormality of salivation |
| HP:0000414 | 0.0107832081447 | 0.6 | AP4E1 AP4S1 AP4M1 | Bulbous nose |
| HP:0002465 | 0.0107832081447 | 0.6 | AP4E1 AP4S1 AP4M1 | Poor speech |
| GO:0005802 | 0.0116840674116 | 0.8 | TEPSIN AP4S1 AP4E1 AP4M1 | trans-Golgi network |
| HP:0010551 | 0.0149955818628 | 0.6 | AP4E1 AP4S1 AP4M1 | Paraplegia/paraparesis |
| HP:0000154 | 0.0154684004463 | 0.6 | AP4E1 AP4S1 AP4M1 | Wide mouth |
| HP:0002061 | 0.0174583232226 | 0.6 | AP4E1 AP4S1 AP4M1 | Lower limb spasticity |
| HP:0000280 | 0.019057059631 | 0.6 | AP4E1 AP4S1 AP4M1 | Coarse facial features |
| HP:0002352 | 0.0198915186532 | 0.6 | AP4E1 AP4S1 AP4M1 | Leukoencephalopathy |
| GO:0098791 | 0.0223258532034 | 0.8 | TEPSIN AP4S1 AP4E1 AP4M1 | Golgi apparatus subcompartment |
| HP:0000322 | 0.0250797490255 | 0.6 | AP4E1 AP4S1 AP4M1 | Short philtrum |
| HP:0000733 | 0.0296001658067 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal repetitive mannerisms |
| HP:0031432 | 0.0296001658067 | 0.6 | AP4E1 AP4S1 AP4M1 | Restricted or repetitive behaviors or interests |
| HP:0031828 | 0.0354490916891 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal superficial reflex |
| HP:0003487 | 0.0354490916891 | 0.6 | AP4E1 AP4S1 AP4M1 | Babinski sign |
| HP:0002355 | 0.0371281686934 | 0.6 | AP4E1 AP4S1 AP4M1 | Difficulty walking |
| HP:0031815 | 0.0458227809051 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormal oral physiology |
| HP:0000301 | 0.0458227809051 | 0.6 | AP4E1 AP4S1 AP4M1 | Abnormality of facial musculature |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP4E1 | TEPSIN | 1.0 | 0.138 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4M1 | AP4E1 | 1.0 | 0.17 |
mutually_exclusive (Q9Y587)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4M1 | TEPSIN | 1.0 | 0.078 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 | |
| AP4S1 | AP4M1 | 0.999 | 0.112 |
mutually_exclusive (Q9Y6B7)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| AP4S1 | AP4E1 | 0.999 | 0.166342857143 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| AP4S1 | TEPSIN | 0.998 | 0.126 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CLEC4G | TEPSIN | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| AP4M1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4E1 | CLEC4G | 0.278 | bioplex3_WMM WMM_only | ||
| AP4S1 | CLEC4G | 0.274 | bioplex3_WMM WMM_only |
Related Complexes