hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03146.1

Complex Portal: CPX-16470

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PIGH	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H)	5	UniProt NCBI
PIGQ	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q)	5	UniProt NCBI
CYP4F11	Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78)	5	UniProt NCBI
KCNH2	Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)	5	UniProt NCBI
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	5	UniProt NCBI
ABCC10	ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7)	5	UniProt NCBI
ENTREP3	Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)	5	UniProt NCBI
PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)	5	UniProt NCBI
SLC4A11	Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1)	5	UniProt NCBI
PIGA	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A)	5	UniProt NCBI
ANO1	Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2)	5	UniProt NCBI
AREL1	Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)	5	UniProt NCBI
DHRS3	Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1)	5	UniProt NCBI
IL18RAP	Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:118	3.65216022462e-08	0.214285714286	PIGH PIGA PIGQ	GPI-GnT activity complex
GO:0000506	1.31622611039e-07	0.285714285714	PIGH PIGP PIGA PIGQ	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
KEGG:00563	1.73723337966e-07	0.285714285714	PIGH PIGP PIGA PIGQ	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
REAC:R-HSA-162710	4.3023961342e-05	0.214285714286	PIGH PIGA PIGP	Synthesis of glycosylphosphatidylinositol (GPI)
GO:0006506	0.000276827676899	0.285714285714	PIGH PIGP PIGA PIGQ	GPI anchor biosynthetic process
GO:0006505	0.000329376191771	0.285714285714	PIGH PIGP PIGA PIGQ	GPI anchor metabolic process
REAC:R-HSA-163125	0.00829016430714	0.214285714286	PIGH PIGA PIGP	Post-translational modification: synthesis of GPI-anchored proteins
GO:0009247	0.0116315040525	0.285714285714	PIGH PIGP PIGA PIGQ	glycolipid biosynthetic process
GO:0006497	0.0172460095997	0.285714285714	PIGH PIGP PIGA PIGQ	protein lipidation
GO:0042158	0.0183485824937	0.285714285714	PIGH PIGP PIGA PIGQ	lipoprotein biosynthetic process
HP:0010841	0.0259278542726	0.214285714286	PIGQ PIGA PIGP	Multifocal epileptiform discharges
HP:0020221	0.0313967924823	0.214285714286	PIGQ PIGA PIGP	Clonic seizure
GO:0042157	0.0399566756791	0.285714285714	PIGH PIGP PIGA PIGQ	lipoprotein metabolic process
KEGG:01100	0.0431573281632	0.428571428571	PIGQ HMGCR PIGH DHRS3 PIGA PIGP	Metabolic pathways
GO:0006664	0.0463487954988	0.285714285714	PIGH PIGP PIGA PIGQ	glycolipid metabolic process
GO:1903509	0.0463487954988	0.285714285714	PIGH PIGP PIGA PIGQ	liposaccharide metabolic process
CORUM:6571	0.0499958217778	0.0714285714286	KCNH2	KCNE1-KCNH2 complex
CORUM:6578	0.0499958217778	0.0714285714286	KCNH2	KCNE2-KCNH2 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PIGP	PIGH	1.0		mutually_exclusive (P37287) structurally_consistent (dimer)
KCNH2	PIGH	0.998
PIGH	SLC4A11	0.997	0.136
PIGH	CYP4F11	0.997	0.1
PIGH	ENTREP3	0.995
PIGA	PIGH	0.992	0.11	mutually_exclusive (P57054) structurally_consistent (dimer)
PIGH	ANO1	0.991	0.092
PIGH	PIGQ	0.99	0.094
ABCC10	PIGH	0.99	0.08
DHRS3	PIGH	0.99	0.06
PIGH	AREL1	0.986
IL18RAP	PIGH	0.983
HMGCR	AREL1	0.975
ENTREP3	AREL1	0.975
PIGH	HMGCR	0.974	0.11
PIGA	PIGP	0.97		structurally_consistent (dimer)
PIGA	IL18RAP	0.969
PIGA	AREL1	0.965
PIGA	ENTREP3	0.963
PIGA	HMGCR	0.908	0.114
PIGP	ANO1	0.904
PIGP	CYP4F11	0.902
PIGP	SLC4A11	0.902
KCNH2	CYP4F11	0.902
CYP4F11	SLC4A11	0.902	0.076
KCNH2	SLC4A11	0.902
KCNH2	PIGP	0.902
DHRS3	SLC4A11	0.902	0.052
KCNH2	ANO1	0.902
CYP4F11	ANO1	0.902	0.124
DHRS3	CYP4F11	0.902	0.252
SLC4A11	ANO1	0.902	0.044
KCNH2	DHRS3	0.892
CYP4F11	AREL1	0.869
SLC4A11	AREL1	0.869
ABCC10	PIGA	0.828	0.144
PIGA	DHRS3	0.776	0.078
PIGP	DHRS3	0.768
ABCC10	PIGQ	0.763	0.078
PIGQ	CYP4F11	0.73	0.126
PIGQ	SLC4A11	0.73	0.054
KCNH2	AREL1	0.73
HMGCR	ENTREP3	0.727
PIGQ	AREL1	0.718
ABCC10	CYP4F11	0.715	0.086
ABCC10	SLC4A11	0.715	0.054
ABCC10	ENTREP3	0.696
PIGQ	ENTREP3	0.692
PIGA	SLC4A11	0.675	0.102
KCNH2	PIGQ	0.675
PIGP	PIGQ	0.675
KCNH2	PIGA	0.675
PIGA	CYP4F11	0.675	0.16
PIGP	AREL1	0.675
ABCC10	PIGP	0.675
PIGQ	ANO1	0.675	0.118
KCNH2	ABCC10	0.675
DHRS3	PIGQ	0.653	0.134
CYP4F11	ENTREP3	0.652
ENTREP3	SLC4A11	0.652
PIGA	PIGQ	0.639	0.108
PIGA	ANO1	0.606	0.066
KCNH2	ENTREP3	0.552
ABCC10	AREL1	0.546
PIGP	ENTREP3	0.545
ABCC10	DHRS3	0.527	0.062
DHRS3	ENTREP3	0.51
PIGQ	HMGCR	0.479	0.108
DHRS3	ANO1	0.401	0.124
ANO1	AREL1	0.356
DHRS3	AREL1	0.343
ABCC10	ANO1	0.343	0.074
CYP4F11	HMGCR	0.292	0.128
HMGCR	SLC4A11	0.292	0.072
PIGP	HMGCR	0.283
ENTREP3	ANO1	0.261
KCNH2	HMGCR	0.235
ABCC10	HMGCR	0.227	0.104
HMGCR	ANO1	0.154	0.106
DHRS3	HMGCR	0.148	0.06

Related Complexes

Genename	Complexes
PIGH	huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_15113.1
PIGQ	huMAP3_03146.1 huMAP3_04385.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_11593.1 huMAP3_12160.1 huMAP3_12877.1 huMAP3_15019.1 huMAP3_15113.1
CYP4F11	huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_13180.1 huMAP3_14053.1
KCNH2	huMAP3_00913.1 huMAP3_03146.1 huMAP3_07567.1 huMAP3_13180.1 huMAP3_14053.1
HMGCR	huMAP3_03146.1 huMAP3_15113.1
ABCC10	huMAP3_02164.1 huMAP3_03146.1 huMAP3_07757.1 huMAP3_08888.1 huMAP3_15113.1
ENTREP3	huMAP3_03146.1 huMAP3_04446.1 huMAP3_05985.1 huMAP3_06467.1 huMAP3_07567.1 huMAP3_07790.1 huMAP3_07953.1 huMAP3_09484.1 huMAP3_10060.1 huMAP3_15113.1 huMAP3_15126.1
PIGP	huMAP3_02836.1 huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_13180.1 huMAP3_14053.1
SLC4A11	huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_13180.1 huMAP3_14053.1
PIGA	huMAP3_02836.1 huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_13102.1 huMAP3_15113.1
ANO1	huMAP3_03146.1 huMAP3_04609.1 huMAP3_08888.1 huMAP3_09336.1 huMAP3_09405.1 huMAP3_12142.1 huMAP3_13180.1 huMAP3_14053.1
AREL1	huMAP3_03146.1 huMAP3_07567.1 huMAP3_10323.1 huMAP3_15093.1 huMAP3_15113.1
DHRS3	huMAP3_03028.1 huMAP3_03146.1 huMAP3_08888.1 huMAP3_11853.1 huMAP3_13180.1 huMAP3_14053.1 huMAP3_14647.1
IL18RAP	huMAP3_02836.1 huMAP3_03146.1 huMAP3_07567.1 huMAP3_08888.1 huMAP3_13102.1 huMAP3_15113.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_03146.1

Complex Portal: CPX-16470