hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03149.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | 5 | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | 5 | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | 5 | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | 5 | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | 5 | UniProt NCBI |
| AP3S2 | AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) | 5 | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 3.69911140533e-24 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | AP3 adaptor complex |
| GO:0035654 | 1.77187436315e-21 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| GO:0035652 | 1.77187436315e-21 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | clathrin-coated vesicle cargo loading |
| CORUM:652 | 2.38037818933e-20 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | AP3-BLOC1 complex |
| GO:0030123 | 6.37874770736e-20 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | AP-3 adaptor complex |
| GO:0048490 | 5.6388129733e-17 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | anterograde synaptic vesicle transport |
| GO:0099514 | 5.6388129733e-17 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | synaptic vesicle cytoskeletal transport |
| GO:0099517 | 5.6388129733e-17 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | synaptic vesicle transport along microtubule |
| GO:0035459 | 4.65927652849e-15 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle cargo loading |
| GO:0048489 | 5.96387395647e-15 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | synaptic vesicle transport |
| GO:0030119 | 1.19150045925e-14 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | AP-type membrane coat adaptor complex |
| GO:0097479 | 1.82422828934e-14 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | synaptic vesicle localization |
| GO:0047496 | 3.983517312e-14 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle transport along microtubule |
| GO:0008089 | 4.7802207744e-14 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | anterograde axonal transport |
| KEGG:04142 | 1.3136608824e-13 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | Lysosome |
| GO:0016183 | 1.89092208334e-13 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle coating |
| GO:0098930 | 3.13799941964e-13 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | axonal transport |
| GO:0008088 | 6.84310140421e-13 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | axo-dendritic transport |
| GO:0099518 | 9.8032611783e-13 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle cytoskeletal trafficking |
| GO:0072384 | 2.35639924599e-12 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | organelle transport along microtubule |
| GO:0016185 | 3.97003041564e-12 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0070142 | 3.97003041564e-12 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle budding |
| GO:0030117 | 1.0353692615e-11 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | membrane coat |
| GO:0048475 | 1.0353692615e-11 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | coated membrane |
| GO:0010970 | 2.58594976163e-10 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | transport along microtubule |
| GO:0099111 | 6.00303577729e-10 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | microtubule-based transport |
| GO:0051650 | 1.16994821771e-09 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | establishment of vesicle localization |
| GO:0030705 | 1.44189762778e-09 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | cytoskeleton-dependent intracellular transport |
| GO:0051648 | 1.50233645051e-09 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle localization |
| GO:1903232 | 1.61774021211e-09 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | melanosome assembly |
| GO:0060155 | 3.84081723488e-09 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | platelet dense granule organization |
| GO:0005769 | 3.40013315453e-08 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | early endosome |
| GO:0007018 | 3.49028820029e-08 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | microtubule-based movement |
| GO:0016050 | 4.51063082443e-08 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle organization |
| WP:WP5408 | 5.97191980241e-08 | 0.571428571429 | AP3M2 AP3B2 AP3D1 AP3S1 | 15q25 copy number variation |
| GO:0006901 | 6.1175480481e-08 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | vesicle coating |
| GO:0048753 | 7.1034375646e-08 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | pigment granule organization |
| GO:0032438 | 7.1034375646e-08 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | melanosome organization |
| GO:0033363 | 9.4556351205e-08 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | secretory granule organization |
| GO:0048488 | 2.29972126346e-07 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle endocytosis |
| GO:0140238 | 2.29972126346e-07 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | presynaptic endocytosis |
| GO:0051656 | 2.97622789789e-07 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | establishment of organelle localization |
| GO:0036465 | 5.94667985582e-07 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle recycling |
| GO:0033059 | 6.54059959197e-07 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | cellular pigmentation |
| GO:0051640 | 1.67755128319e-06 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | organelle localization |
| GO:0006900 | 2.62550964059e-06 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | vesicle budding from membrane |
| GO:0043473 | 2.81823908869e-06 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | pigmentation |
| GO:0099504 | 1.80511788521e-05 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | synaptic vesicle cycle |
| CORUM:2308 | 2.05265451394e-05 | 0.285714285714 | AP3S1 AP3D1 | AP3D1-AP3S1 complex |
| CORUM:2307 | 2.05265451394e-05 | 0.285714285714 | AP3D1 AP3S2 | AP3D1-AP3S2 complex |
| GO:0099003 | 2.0831028993e-05 | 0.714285714286 | AP3S2 AP3M2 AP3B2 AP3D1 AP3S1 | vesicle-mediated transport in synapse |
| GO:0007017 | 2.64445381062e-05 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | microtubule-based process |
| GO:0005768 | 3.07342837776e-05 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | endosome |
| GO:0098796 | 0.000196114631356 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | membrane protein complex |
| GO:0006897 | 0.000304470789292 | 0.857142857143 | AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | endocytosis |
| GO:0046907 | 0.000594741825979 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | intracellular transport |
| GO:0016192 | 0.000663584374918 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | vesicle-mediated transport |
| GO:0098657 | 0.00153212690263 | 0.857142857143 | AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | import into cell |
| HP:0011125 | 0.00166533696614 | 0.285714285714 | AP3B1 AP3D1 | Abnormality of dermal melanosomes |
| GO:0051649 | 0.00341941525307 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | establishment of localization in cell |
| GO:0031410 | 0.0119560068448 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | cytoplasmic vesicle |
| GO:0097708 | 0.0121085422015 | 1.0 | AP3B1 AP3M1 AP3M2 AP3S2 AP3S1 AP3D1 AP3B2 | intracellular vesicle |
| HP:0001022 | 0.0199339480346 | 0.285714285714 | AP3B1 AP3D1 | Albinism |
| GO:0010256 | 0.0233487573869 | 0.714285714286 | AP3S2 AP3B1 AP3D1 AP3S1 AP3M1 | endomembrane system organization |
| HP:0001107 | 0.0348446257606 | 0.285714285714 | AP3B1 AP3D1 | Ocular albinism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP3M1 | AP3S1 | 1.0 | 0.522 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3S1 | AP3B2 | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3M1 | AP3B2 | 1.0 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| AP3B1 | AP3S1 | 1.0 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3M1 | 1.0 | 0.782 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AP3M1 | AP3D1 | 1.0 | 0.794 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3M2 | AP3S1 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3S1 | AP3D1 | 0.999 | 0.482 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| AP3B1 | AP3M2 | 0.999 | 0.28 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3M2 | AP3M1 | 0.998 | 0.636 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3M2 | AP3D1 | 0.995 | 0.604 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| AP3B1 | AP3D1 | 0.993 | 0.806 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3M1 | AP3S2 | 0.991 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| AP3B1 | AP3B2 | 0.991 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3M2 | AP3B2 | 0.98 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only |
| AP3M2 | AP3S2 | 0.978 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AP3S1 | AP3S2 | 0.94 | 0.064 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3S2 | 0.938 | 0.136 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3D1 | AP3B2 | 0.921 | 0.038 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AP3B1 | AP3S2 | 0.834 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP3S2 | AP3B2 | 0.747 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes