hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03161.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein) | 5 | UniProt NCBI |
| TOPBP1 | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | 5 | UniProt NCBI |
| DNAJC4 | DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6732 | 3.41752350426e-06 | 0.666666666667 | TOPBP1 RHNO1 | RHINO-TopBP1 complex |
| REAC:R-HSA-9709570 | 0.00381957013228 | 0.666666666667 | TOPBP1 RHNO1 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 0.00405087414568 | 0.666666666667 | TOPBP1 RHNO1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 0.00504394814871 | 0.666666666667 | TOPBP1 RHNO1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 0.00530917647079 | 0.666666666667 | TOPBP1 RHNO1 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 0.00530917647079 | 0.666666666667 | TOPBP1 RHNO1 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 0.00585997836812 | 0.666666666667 | TOPBP1 RHNO1 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-9675135 | 0.00800131218049 | 0.666666666667 | TOPBP1 RHNO1 | Diseases of DNA repair |
| REAC:R-HSA-5685942 | 0.0145828870271 | 0.666666666667 | TOPBP1 RHNO1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-69473 | 0.0254089329805 | 0.666666666667 | TOPBP1 RHNO1 | G2/M DNA damage checkpoint |
| REAC:R-HSA-6804756 | 0.0265950995478 | 0.666666666667 | TOPBP1 RHNO1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.0271982878007 | 0.666666666667 | TOPBP1 RHNO1 | Processing of DNA double-strand break ends |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TOPBP1 | DNAJC4 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TOPBP1 | RHNO1 | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RHNO1 | huMAP3_03161.1 huMAP3_05223.1 huMAP3_12787.1 |
| TOPBP1 | huMAP3_02497.1 huMAP3_03161.1 huMAP3_03983.1 huMAP3_10078.1 |
| DNAJC4 | huMAP3_03161.1 huMAP3_03983.1 huMAP3_04203.1 huMAP3_06921.1 huMAP3_06964.1 huMAP3_07406.1 huMAP3_14088.1 |