hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03164.1
Complex Portal: CPX-15390
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIN52 | Protein lin-52 homolog | 3 | UniProt NCBI |
| LIN37 | Protein lin-37 homolog (Antolefinin) | 5 | UniProt NCBI |
| LIN54 | Protein lin-54 homolog (CXC domain-containing protein 1) | 5 | UniProt NCBI |
| MYBL2 | Myb-related protein B (B-Myb) (Myb-like protein 2) | 5 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | 5 | UniProt NCBI |
| MYBL1 | Myb-related protein A (A-Myb) (Myb-like protein 1) | 5 | UniProt NCBI |
| LIN9 | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | 5 | UniProt NCBI |
| TESMIN | Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5589 | 1.91772524101e-12 | 0.8 | LIN9 LIN37 RBL1 LIN54 | LINC complex, S-phase |
| REAC:R-HSA-1362300 | 5.82712811345e-10 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 1.30608654531e-09 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Transcription of E2F targets under negative control by DREAM complex |
| REAC:R-HSA-1538133 | 6.37824653444e-09 | 0.8 | LIN9 LIN37 RBL1 LIN54 | G0 and Early G1 |
| REAC:R-HSA-69205 | 7.4870963414e-09 | 0.8 | LIN9 LIN37 RBL1 LIN54 | G1/S-Specific Transcription |
| CORUM:5593 | 1.12081835382e-08 | 0.6 | LIN37 LIN9 LIN54 | LINC core complex |
| WP:WP5180 | 5.21269766855e-08 | 0.8 | LIN9 LIN37 RBL1 LIN54 | DYRK1A involvement regarding cell proliferation in brain development |
| CORUM:5596 | 5.60294116544e-08 | 0.6 | LIN37 LIN9 LIN54 | LINC complex, quiescent cells |
| REAC:R-HSA-156711 | 1.41820648707e-06 | 0.6 | LIN37 LIN9 LIN54 | Polo-like kinase mediated events |
| KEGG:04218 | 1.94348974044e-06 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Cellular senescence |
| REAC:R-HSA-69206 | 4.81850742601e-06 | 0.8 | LIN9 LIN37 RBL1 LIN54 | G1/S Transition |
| REAC:R-HSA-453279 | 7.91332898893e-06 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69202 | 0.000274139762819 | 0.6 | LIN37 LIN9 LIN54 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 0.00029489329261 | 0.6 | LIN37 LIN9 LIN54 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-69278 | 0.00130844914147 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Cell Cycle, Mitotic |
| REAC:R-HSA-69242 | 0.00201875981781 | 0.6 | LIN37 LIN9 LIN54 | S Phase |
| REAC:R-HSA-1640170 | 0.00298118644627 | 0.8 | LIN9 LIN37 RBL1 LIN54 | Cell Cycle |
| REAC:R-HSA-69275 | 0.0033903418593 | 0.6 | LIN37 LIN9 LIN54 | G2/M Transition |
| REAC:R-HSA-453274 | 0.0034989765428 | 0.6 | LIN37 LIN9 LIN54 | Mitotic G2-G2/M phases |
| CORUM:839 | 0.0498708842806 | 0.2 | LIN9 | LIN9-BMYB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LIN37 | LIN54 | 1.0 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN37 | LIN9 | 1.0 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN52 | LIN9 | 1.0 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIN37 | MYBL2 | 1.0 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN54 | LIN9 | 1.0 | 0.324 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN52 | LIN37 | 1.0 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MYBL2 | LIN9 | 1.0 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| MYBL1 | LIN9 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIN37 | MYBL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIN52 | MYBL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIN52 | LIN54 | 0.998 | 0.21 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LIN54 | MYBL1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIN52 | MYBL2 | 0.99 | 0.184 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LIN37 | TESMIN | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LIN9 | TESMIN | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LIN37 | RBL1 | 0.967 | 0.16 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYBL2 | MYBL1 | 0.967 | bioplex_WMM bioplex3_WMM WMM_only | ||
| LIN54 | MYBL2 | 0.965 | 0.206 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RBL1 | LIN9 | 0.962 | 0.184 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RBL1 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| LIN52 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| MYBL1 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| MYBL2 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| LIN54 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| RBL1 | MYBL1 | 0.616 | bioplex3_WMM WMM_only | ||
| MYBL2 | RBL1 | 0.616 | 0.238 | bioplex3_WMM WMM_only | |
| LIN52 | RBL1 | 0.404 | 0.108 | bioplex3_WMM WMM_only | |
| LIN54 | RBL1 | 0.372 | 0.206 | bioplex3_WMM WMM_only |
Related Complexes