hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03188.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ELOB | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | 5 | UniProt NCBI |
| ELOC | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | 5 | UniProt NCBI |
| AMBRA1 | Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) | 5 | UniProt NCBI |
| SOCS3 | Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9705462 | 2.4825378684e-06 | 0.75 | ELOC ELOB SOCS3 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-9674555 | 4.59102468944e-06 | 0.75 | ELOC ELOB SOCS3 | Signaling by CSF3 (G-CSF) |
| CORUM:6738 | 5.12628525639e-06 | 0.5 | ELOC ELOB | PRAME-ElonginBC ubiquitin ligase |
| CORUM:7576 | 1.53774525569e-05 | 0.5 | ELOC ELOB | VHL-ElonginB-ElonginC complex |
| CORUM:5270 | 1.53774525569e-05 | 0.5 | ELOC ELOB | VHL-TCEB1-TCEB2 complex |
| CORUM:6485 | 3.07520988333e-05 | 0.5 | ELOC ELOB | HIF1alpha-VHL-ElonginB-ElonginC complex |
| CORUM:622 | 3.07520988333e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) |
| CORUM:5267 | 3.07520988333e-05 | 0.5 | ELOC ELOB | VHL-VDU1-TCEB1-TCEB2 complex |
| CORUM:211 | 3.07520988333e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:6268 | 3.07520988333e-05 | 0.5 | ELOC ELOB | Cullin-RING E3 ubiquitin ligase complex |
| CORUM:207 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:205 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
| CORUM:209 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:208 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:210 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:214 | 5.12488211613e-05 | 0.5 | ELOC ELOB | Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) |
| WP:WP3300 | 5.36057998926e-05 | 0.5 | ELOC ELOB | Dual hijack model of Vif in HIV infection |
| WP:WP4860 | 7.14678770193e-05 | 0.5 | ELOC ELOB | Hijack of ubiquitination by SARS CoV 2 |
| CORUM:7556 | 7.68662167609e-05 | 0.5 | ELOC ELOB | PRAME complex |
| KEGG:04120 | 0.000136723260154 | 0.75 | ELOC ELOB SOCS3 | Ubiquitin mediated proteolysis |
| WP:WP4241 | 0.00126323103486 | 0.5 | ELOC ELOB | Type 2 papillary renal cell carcinoma |
| REAC:R-HSA-8951664 | 0.00259854618679 | 0.75 | ELOC ELOB SOCS3 | Neddylation |
| REAC:R-HSA-167238 | 0.00444848198459 | 0.5 | ELOC ELOB | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.00444848198459 | 0.5 | ELOC ELOB | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 0.00507136546841 | 0.5 | ELOC ELOB | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 0.00507136546841 | 0.5 | ELOC ELOB | HIV elongation arrest and recovery |
| REAC:R-HSA-983168 | 0.00511471388221 | 0.75 | ELOC ELOB SOCS3 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:05211 | 0.00518715200321 | 0.5 | ELOC ELOB | Renal cell carcinoma |
| GO:0070449 | 0.00842684400117 | 0.5 | ELOC ELOB | elongin complex |
| GO:0140958 | 0.00842684400117 | 0.5 | ELOC ELOB | target-directed miRNA degradation |
| REAC:R-HSA-167246 | 0.008795277704 | 0.5 | ELOC ELOB | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 0.008795277704 | 0.5 | ELOC ELOB | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 0.008795277704 | 0.5 | ELOC ELOB | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-983169 | 0.00943434452943 | 0.75 | ELOC ELOB SOCS3 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-167152 | 0.00966180252737 | 0.5 | ELOC ELOB | Formation of HIV elongation complex in the absence of HIV Tat |
| KEGG:04066 | 0.0120599434394 | 0.5 | ELOC ELOB | HIF-1 signaling pathway |
| REAC:R-HSA-180585 | 0.0135329645116 | 0.5 | ELOC ELOB | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-75955 | 0.0162811003561 | 0.5 | ELOC ELOB | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.0162811003561 | 0.5 | ELOC ELOB | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-6796648 | 0.0186613511621 | 0.5 | ELOC ELOB | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-1234176 | 0.0199119958937 | 0.5 | ELOC ELOB | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-167172 | 0.0232149434748 | 0.5 | ELOC ELOB | Transcription of the HIV genome |
| REAC:R-HSA-1234174 | 0.0246065982605 | 0.5 | ELOC ELOB | Cellular response to hypoxia |
| REAC:R-HSA-674695 | 0.0313666733646 | 0.5 | ELOC ELOB | RNA Polymerase II Pre-transcription Events |
| KEGG:05170 | 0.0456663239038 | 0.5 | ELOC ELOB | Human immunodeficiency virus 1 infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ELOB | ELOC | 1.0 | 0.944 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| ELOC | AMBRA1 | 0.992 | 0.21 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| AMBRA1 | SOCS3 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELOB | SOCS3 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELOC | SOCS3 | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELOB | AMBRA1 | 0.952 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes