hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03191.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DEGS1 | Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-) | 5 | UniProt NCBI |
| UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | 5 | UniProt NCBI |
| NPLOC4 | Nuclear protein localization protein 4 homolog (Protein NPL4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6280 | 2.05032700758e-05 | 0.666666666667 | NPLOC4 UFD1 | NUB1L-UFD1-NPL4-NEDD8 complex |
| REAC:R-HSA-110320 | 0.0011650518872 | 0.666666666667 | NPLOC4 UFD1 | Translesion Synthesis by POLH |
| GO:0036501 | 0.00140460216025 | 0.666666666667 | NPLOC4 UFD1 | UFD1-NPL4 complex |
| REAC:R-HSA-110313 | 0.00478550282195 | 0.666666666667 | NPLOC4 UFD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-73893 | 0.00735562020533 | 0.666666666667 | NPLOC4 UFD1 | DNA Damage Bypass |
| KEGG:04141 | 0.00916431091176 | 0.666666666667 | NPLOC4 UFD1 | Protein processing in endoplasmic reticulum |
| GO:0039536 | 0.0140440992017 | 0.666666666667 | NPLOC4 UFD1 | negative regulation of RIG-I signaling pathway |
| REAC:R-HSA-9755511 | 0.0363497159339 | 0.666666666667 | NPLOC4 UFD1 | KEAP1-NFE2L2 pathway |
| GO:0034098 | 0.0393180950424 | 0.666666666667 | NPLOC4 UFD1 | VCP-NPL4-UFD1 AAA ATPase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFD1 | NPLOC4 | 1.0 | 0.738 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| DEGS1 | NPLOC4 | 0.965 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DEGS1 | UFD1 | 0.936 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| DEGS1 | huMAP3_01234.1 huMAP3_03191.1 huMAP3_06004.1 huMAP3_06937.1 huMAP3_10598.1 huMAP3_13609.1 |
| UFD1 | huMAP3_03191.1 huMAP3_10598.1 huMAP3_13609.1 huMAP3_15201.1 |
| NPLOC4 | huMAP3_03191.1 huMAP3_10598.1 huMAP3_13609.1 |