hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03197.1

Complex Portal: CPX-14201

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
WDR87	WD repeat-containing protein 87 (Testis development protein NYD-SP11)	3	UniProt NCBI
SETD5	Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)	5	UniProt NCBI
NCOR1	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	5	UniProt NCBI
TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)	5	UniProt NCBI
NCOR2	Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)	5	UniProt NCBI
ANKRD11	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	5	UniProt NCBI
GPS2	G protein pathway suppressor 2 (GPS-2)	5	UniProt NCBI
TBL1X	F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9022537	1.28721601153e-14	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Loss of MECP2 binding ability to the NCoR/SMRT complex
REAC:R-HSA-9005891	5.40260728514e-13	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Loss of function of MECP2 in Rett syndrome
REAC:R-HSA-9697154	5.40260728514e-13	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Disorders of Nervous System Development
REAC:R-HSA-9005895	5.40260728514e-13	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Pervasive developmental disorders
REAC:R-HSA-9675151	5.40260728514e-13	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Disorders of Developmental Biology
CORUM:741	1.68018318789e-11	0.5	TBL1X TBL1XR1 NCOR1 GPS2	NCOR-HDAC3 complex
CORUM:58	1.68018318789e-11	0.5	TBL1X TBL1XR1 GPS2 NCOR2	SMRT complex
CORUM:15	5.03944556454e-11	0.5	TBL1X TBL1XR1 NCOR1 GPS2	NCOR complex
REAC:R-HSA-9022692	2.53770772028e-10	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Regulation of MECP2 expression and activity
REAC:R-HSA-9029569	3.62962999131e-10	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
CORUM:2183	7.0490440398e-10	0.5	TBL1X TBL1XR1 NCOR1 GPS2	Kaiso-NCOR complex
WP:WP4312	7.7780255084e-10	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Rett syndrome causing genes
REAC:R-HSA-9024446	1.22824377961e-09	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	NR1H2 and NR1H3-mediated signaling
REAC:R-HSA-8986944	6.1071250098e-09	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Transcriptional Regulation by MECP2
REAC:R-HSA-3214815	5.09241824227e-08	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	HDACs deacetylate histones
REAC:R-HSA-350054	5.71078496603e-08	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Notch-HLH transcription pathway
REAC:R-HSA-1989781	1.51014067495e-07	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	PPARA activates gene expression
REAC:R-HSA-400206	1.58934837241e-07	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Regulation of lipid metabolism by PPARalpha
REAC:R-HSA-9609690	4.00935131734e-07	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	HCMV Early Events
REAC:R-HSA-2122947	7.10666264099e-07	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	NOTCH1 Intracellular Domain Regulates Transcription
REAC:R-HSA-9609646	9.39081445557e-07	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	HCMV Infection
REAC:R-HSA-2894858	1.38487166109e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REAC:R-HSA-2644603	1.38487166109e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Signaling by NOTCH1 in Cancer
REAC:R-HSA-2644606	1.38487166109e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REAC:R-HSA-2894862	1.38487166109e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REAC:R-HSA-2644602	1.38487166109e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Signaling by NOTCH1 PEST Domain Mutants in Cancer
GO:0017053	2.28962267525e-06	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	transcription repressor complex
REAC:R-HSA-1980143	3.52441758827e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Signaling by NOTCH1
REAC:R-HSA-9707564	3.52441758827e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Cytoprotection by HMOX1
REAC:R-HSA-381340	9.3792090956e-06	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Transcriptional regulation of white adipocyte differentiation
REAC:R-HSA-9006931	1.51385517358e-05	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Signaling by Nuclear Receptors
REAC:R-HSA-3247509	1.60800453506e-05	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Chromatin modifying enzymes
REAC:R-HSA-4839726	1.60800453506e-05	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Chromatin organization
CORUM:1188	7.17483486175e-05	0.25	NCOR2 TBL1X	SMRT core complex
CORUM:7480	7.17483486175e-05	0.25	NCOR2 NCOR1	HDAC3-H1.3-SMRT-N-Cor complex
CORUM:752	7.17483486175e-05	0.25	NCOR2 TBL1X	SMRT core complex
REAC:R-HSA-9707616	0.000260330782854	0.375	TBL1XR1 NCOR1 TBL1X	Heme signaling
REAC:R-HSA-9711123	0.000340687483594	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Cellular response to chemical stress
GO:0003714	0.000390282000203	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	transcription corepressor activity
REAC:R-HSA-2151201	0.000391615111842	0.375	TBL1XR1 NCOR1 TBL1X	Transcriptional activation of mitochondrial biogenesis
CORUM:1505	0.000501688733948	0.25	NCOR2 NCOR1	NCOR2 complex
REAC:R-HSA-157118	0.000525460865622	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Signaling by NOTCH
REAC:R-HSA-400253	0.00081216394806	0.375	TBL1XR1 NCOR1 TBL1X	Circadian Clock
GO:0000118	0.00115498793492	0.5	TBL1X SETD5 NCOR1 TBL1XR1	histone deacetylase complex
REAC:R-HSA-556833	0.00135885625735	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Metabolism of lipids
REAC:R-HSA-9623433	0.00200443712543	0.25	NCOR2 NCOR1	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
REAC:R-HSA-1592230	0.0022946325687	0.375	TBL1XR1 NCOR1 TBL1X	Mitochondrial biogenesis
REAC:R-HSA-9824446	0.00267983185965	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Viral Infection Pathways
REAC:R-HSA-5663202	0.00561322778787	0.5	TBL1X TBL1XR1 NCOR1 NCOR2	Diseases of signal transduction by growth factor receptors and second messengers
REAC:R-HSA-1368082	0.00666866305696	0.25	TBL1XR1 TBL1X	RORA activates gene expression
HPA:0490692	0.00688674603574	0.875	ANKRD11 NCOR1 SETD5 NCOR2 TBL1XR1 TBL1X GPS2	smooth muscle; smooth muscle cells[>=Medium]
REAC:R-HSA-5663205	0.00732097255999	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Infectious disease
HPA:0270363	0.013058488019	0.75	SETD5 NCOR1 ANKRD11 TBL1X GPS2 TBL1XR1	kidney; cells in tubules[High]
REAC:R-HSA-1368108	0.0140328389809	0.25	TBL1XR1 TBL1X	BMAL1:CLOCK,NPAS2 activates circadian gene expression
REAC:R-HSA-212436	0.0167421784996	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	Generic Transcription Pathway
HPA:0170251	0.0169899383154	0.875	ANKRD11 NCOR1 SETD5 NCOR2 TBL1XR1 TBL1X GPS2	endometrium 2; cells in endometrial stroma[>=Low]
WP:WP61	0.0223720274659	0.25	NCOR2 NCOR1	Notch signaling pathway
REAC:R-HSA-2173795	0.0224821270291	0.25	NCOR2 NCOR1	Downregulation of SMAD2/3:SMAD4 transcriptional activity
GO:0005667	0.0229204338906	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	transcription regulator complex
HPA:0630222	0.0249041935213	0.875	ANKRD11 NCOR1 SETD5 NCOR2 TBL1XR1 TBL1X GPS2	cervix; squamous epithelial cells[>=Medium]
REAC:R-HSA-383280	0.0274432906045	0.25	NCOR2 NCOR1	Nuclear Receptor transcription pathway
REAC:R-HSA-73857	0.0284039231402	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	RNA Polymerase II Transcription
REAC:R-HSA-2426168	0.0367988237757	0.25	TBL1XR1 TBL1X	Activation of gene expression by SREBF (SREBP)
HPA:0400053	0.0405975965631	0.75	SETD5 NCOR1 ANKRD11 TBL1X GPS2 TBL1XR1	rectum; glandular cells[High]
HPA:0160251	0.0461011612967	0.875	ANKRD11 NCOR1 SETD5 NCOR2 TBL1XR1 TBL1X GPS2	endometrium 1; cells in endometrial stroma[>=Low]
HPA:0600432	0.0465230549318	0.875	ANKRD11 NCOR1 SETD5 NCOR2 TBL1XR1 TBL1X GPS2	tonsil; germinal center cells[>=Medium]
GO:0003712	0.0481643445486	0.625	TBL1X TBL1XR1 GPS2 NCOR1 NCOR2	transcription coregulator activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
NCOR1	GPS2	1.0	0.152		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
NCOR2	GPS2	1.0	0.274		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
TBL1XR1	GPS2	1.0	0.166	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
GPS2	TBL1X	1.0	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
ANKRD11	GPS2	0.999	0.136		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
WDR87	GPS2	0.995			bioplex3_WMM bioplex3_HCT116 WMM_only
SETD5	GPS2	0.986	0.132		bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
NCOR1	TBL1XR1	0.969	0.148		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
SETD5	TBL1XR1	0.967	0.112	structurally_consistent (dimer)	hein_WMM bioplex3_WMM youn_WMM hein ()
NCOR2	TBL1X	0.955	0.216		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ANKRD11	TBL1X	0.954	0.066		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR1	TBL1X	0.95	0.154		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR2	ANKRD11	0.92	0.288		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TBL1XR1	ANKRD11	0.913	0.134		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TBL1XR1	TBL1X	0.91	0.954	mutually_exclusive (Q9BQ87) structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
WDR87	ANKRD11	0.908			bioplex3_WMM WMM_only
TBL1XR1	NCOR2	0.89	0.124		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
WDR87	NCOR2	0.89			bioplex3_WMM WMM_only
SETD5	NCOR2	0.89	0.296333333333		hein_WMM bioplex3_WMM youn_WMM hein ()
SETD5	ANKRD11	0.885	0.16		hein_WMM bioplex3_WMM youn_WMM hein ()
NCOR1	ANKRD11	0.885	0.242		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
SETD5	NCOR1	0.862	0.209		hein_WMM bioplex3_WMM youn_WMM hein ()
SETD5	WDR87	0.768			bioplex3_WMM WMM_only
WDR87	TBL1X	0.715			bioplex3_WMM WMM_only
NCOR1	NCOR2	0.676	0.19		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
WDR87	NCOR1	0.675			bioplex3_WMM WMM_only
WDR87	TBL1XR1	0.654			bioplex3_WMM WMM_only
SETD5	TBL1X	0.258	0.046		bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
WDR87	huMAP3_03197.1 huMAP3_04325.1 huMAP3_04657.1 huMAP3_05576.1 huMAP3_05713.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_10289.1 huMAP3_13269.1
SETD5	huMAP3_00867.1 huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_07695.1 huMAP3_12111.1 huMAP3_13269.1
NCOR1	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1XR1	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_13269.1
NCOR2	huMAP3_03197.1 huMAP3_05713.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
ANKRD11	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07614.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
GPS2	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1X	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_03197.1

Complex Portal: CPX-14201