hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03203.1
Complex Portal: CPX-11999
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RINT1 | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | 5 | UniProt NCBI |
| SCFD2 | Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) | 3 | UniProt NCBI |
| NBAS | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | 5 | UniProt NCBI |
| USE1 | Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) | 5 | UniProt NCBI |
| BET1 | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | 5 | UniProt NCBI |
| C19orf25 | UPF0449 protein C19orf25 | 5 | UniProt NCBI |
| BNIP1 | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | 5 | UniProt NCBI |
| STX18 | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | 5 | UniProt NCBI |
| GOSR2 | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | 5 | UniProt NCBI |
| CLEC12A | C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371) | 5 | UniProt NCBI |
| ZW10 | Centromere/kinetochore protein zw10 homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04130 | 7.14136810213e-10 | 0.454545454545 | BNIP1 STX18 GOSR2 USE1 BET1 | SNARE interactions in vesicular transport |
| REAC:R-HSA-6811442 | 5.13578066901e-09 | 0.636363636364 | BNIP1 RINT1 NBAS STX18 GOSR2 ZW10 USE1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-6811434 | 6.57693145155e-09 | 0.545454545455 | BNIP1 RINT1 NBAS STX18 ZW10 USE1 | COPI-dependent Golgi-to-ER retrograde traffic |
| GO:0006890 | 2.67995335791e-08 | 0.545454545455 | BNIP1 RINT1 NBAS STX18 ZW10 USE1 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| REAC:R-HSA-8856688 | 4.20843010097e-08 | 0.545454545455 | BNIP1 RINT1 NBAS STX18 ZW10 USE1 | Golgi-to-ER retrograde transport |
| GO:0048193 | 9.6251552605e-08 | 0.727272727273 | BNIP1 NBAS RINT1 BET1 STX18 GOSR2 ZW10 USE1 | Golgi vesicle transport |
| REAC:R-HSA-199991 | 2.04971495372e-07 | 0.727272727273 | BNIP1 NBAS RINT1 BET1 STX18 GOSR2 ZW10 USE1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 3.15503245116e-07 | 0.727272727273 | BNIP1 NBAS RINT1 BET1 STX18 GOSR2 ZW10 USE1 | Vesicle-mediated transport |
| GO:0031201 | 7.01905212201e-06 | 0.454545454545 | BNIP1 STX18 GOSR2 USE1 BET1 | SNARE complex |
| GO:0070939 | 1.58598067776e-05 | 0.272727272727 | ZW10 RINT1 NBAS | Dsl1/NZR complex |
| CORUM:705 | 0.000102551658964 | 0.181818181818 | RINT1 ZW10 | SNARE complex (RINT1, ZW10, p31) |
| GO:0016192 | 0.00017702999991 | 0.818181818182 | BNIP1 BET1 NBAS RINT1 SCFD2 STX18 GOSR2 ZW10 USE1 | vesicle-mediated transport |
| GO:0005484 | 0.00044927642714 | 0.363636363636 | BNIP1 GOSR2 USE1 BET1 | SNAP receptor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SCFD2 | ZW10 | 1.0 | 0.136 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| BNIP1 | ZW10 | 1.0 | 0.082 |
structurally_consistent (Q6NUQ1)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| RINT1 | ZW10 | 1.0 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| STX18 | RINT1 | 1.0 | 0.18 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SCFD2 | NBAS | 1.0 | 0.508 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| RINT1 | NBAS | 1.0 | 0.066 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| RINT1 | SCFD2 | 1.0 | 0.104 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NBAS | BNIP1 | 1.0 | 0.1 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| RINT1 | C19orf25 | 1.0 | 0.294 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| STX18 | NBAS | 1.0 | 0.12 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| STX18 | SCFD2 | 1.0 | 0.08 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| SCFD2 | BNIP1 | 1.0 | 0.036 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NBAS | ZW10 | 1.0 | 0.122 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| RINT1 | BNIP1 | 1.0 | 0.12 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| USE1 | ZW10 | 1.0 | 0.072 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| C19orf25 | ZW10 | 1.0 | 0.142 |
mutually_exclusive (Q6NUQ1)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| NBAS | USE1 | 1.0 | 0.308 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SCFD2 | C19orf25 | 1.0 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STX18 | BET1 | 1.0 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| STX18 | USE1 | 0.999 | 0.162 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| USE1 | C19orf25 | 0.999 | 0.134 |
mutually_exclusive (Q12981)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SCFD2 | USE1 | 0.999 | 0.326 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NBAS | C19orf25 | 0.999 | 0.184 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| C19orf25 | BNIP1 | 0.999 | 0.072 |
structurally_consistent (Q6NUQ1)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| STX18 | ZW10 | 0.999 | 0.136 |
structurally_consistent (Q6NUQ1)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| STX18 | C19orf25 | 0.999 | 0.332 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| USE1 | BET1 | 0.999 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| USE1 | BNIP1 | 0.998 | 0.17 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| RINT1 | USE1 | 0.998 | 0.20225 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| USE1 | GOSR2 | 0.997 | 0.11 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| BET1 | BNIP1 | 0.996 | 0.13 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| NBAS | BET1 | 0.995 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| STX18 | BNIP1 | 0.995 | 0.364 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| BET1 | GOSR2 | 0.995 | 0.05 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| BNIP1 | GOSR2 | 0.991 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SCFD2 | BET1 | 0.991 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| CLEC12A | STX18 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| BET1 | ZW10 | 0.984 | 0.214 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| STX18 | GOSR2 | 0.983 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CLEC12A | GOSR2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NBAS | GOSR2 | 0.978 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| SCFD2 | GOSR2 | 0.974 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CLEC12A | BNIP1 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RINT1 | GOSR2 | 0.839 | 0.078 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RINT1 | BET1 | 0.837 | 0.084 |
structurally_consistent (Q9H115)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| C19orf25 | GOSR2 | 0.831 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| GOSR2 | ZW10 | 0.831 | 0.108 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| BET1 | C19orf25 | 0.72 | 0.054 |
mutually_exclusive (Q12981)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes