hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03205.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MECOM | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | 5 | UniProt NCBI |
| TWIST2 | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) | 5 | UniProt NCBI |
| ZBTB20 | Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002550 | 0.00549749049527 | 0.666666666667 | TWIST2 ZBTB20 | Absent facial hair |
| HP:0005927 | 0.0128038952176 | 1.0 | TWIST2 MECOM ZBTB20 | Aplasia/hypoplasia involving bones of the hand |
| HP:0002298 | 0.0142438401108 | 0.666666666667 | TWIST2 ZBTB20 | Absent hair |
| HP:0006496 | 0.0156636491543 | 1.0 | TWIST2 MECOM ZBTB20 | Aplasia/hypoplasia involving bones of the upper limbs |
| HP:0003272 | 0.0159610532209 | 1.0 | TWIST2 MECOM ZBTB20 | Abnormal hip bone morphology |
| HP:0011927 | 0.0193708172899 | 1.0 | TWIST2 MECOM ZBTB20 | Short digit |
| HP:0002644 | 0.0223491530492 | 1.0 | TWIST2 MECOM ZBTB20 | Abnormal pelvic girdle bone morphology |
| HP:0045060 | 0.0264474241065 | 1.0 | TWIST2 MECOM ZBTB20 | Aplasia/hypoplasia involving bones of the extremities |
| HP:0005918 | 0.0280139348473 | 1.0 | TWIST2 MECOM ZBTB20 | Abnormal finger phalanx morphology |
| HP:0009815 | 0.0332445138436 | 1.0 | TWIST2 MECOM ZBTB20 | Aplasia/hypoplasia of the extremities |
| HPA:0570773 | 0.035534021141 | 0.666666666667 | ZBTB20 MECOM | testis; peritubular cells[High] |
| HP:0011314 | 0.0383682142819 | 1.0 | TWIST2 MECOM ZBTB20 | Abnormal long bone morphology |
| HP:0002867 | 0.0388502441646 | 0.666666666667 | TWIST2 ZBTB20 | Abnormal ilium morphology |
| HPA:0500703 | 0.047407125424 | 0.666666666667 | ZBTB20 MECOM | soft tissue 1; peripheral nerve[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TWIST2 | ZBTB20 | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MECOM | ZBTB20 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes