hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03257.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GIPC1 | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | 5 | UniProt NCBI |
| GIPC3 | PDZ domain-containing protein GIPC3 | 4 | UniProt NCBI |
| APPL1 | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | 5 | UniProt NCBI |
| APPL2 | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1905303 | 0.0028092043205 | 0.5 | APPL1 APPL2 | positive regulation of macropinocytosis |
| GO:1905449 | 0.0028092043205 | 0.5 | APPL1 APPL2 | regulation of Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:1905301 | 0.00842684400117 | 0.5 | APPL1 APPL2 | regulation of macropinocytosis |
| GO:0033211 | 0.042122686785 | 0.5 | APPL1 APPL2 | adiponectin-activated signaling pathway |
| CORUM:2159 | 0.049938562206 | 0.25 | APPL1 | AR-AKT-APPL complex |
| CORUM:2486 | 0.049938562206 | 0.25 | GIPC1 | GIPC1-LHCGR complex |
| CORUM:2487 | 0.049938562206 | 0.25 | GIPC1 | GIPC1-NTRK1-RGS19 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| APPL1 | APPL2 | 1.0 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| GIPC1 | GIPC3 | 0.999 | 0.06 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GIPC1 | APPL1 | 0.991 | 0.038 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction |
| GIPC1 | APPL2 | 0.983 | 0.064 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GIPC3 | APPL2 | 0.946 | 0.044 | bioplex3_WMM WMM_only |
| GIPC3 | APPL1 | 0.494 | 0.096 | bioplex3_WMM WMM_only |
Related Complexes