hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03261.1
Complex Portal: CPX-10812
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | 5 | UniProt NCBI |
| MAPK7 | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-198765 | 1.70876175213e-06 | 1.0 | MAP2K5 MAPK7 | Signalling to ERK5 |
| WP:WP2795 | 0.00036647347272 | 1.0 | MAP2K5 MAPK7 | Cardiac hypertrophic response |
| KEGG:04540 | 0.000403985690766 | 1.0 | MAP2K5 MAPK7 | Gap junction |
| KEGG:04722 | 0.000804719987643 | 1.0 | MAP2K5 MAPK7 | Neurotrophin signaling pathway |
| WP:WP1544 | 0.000998544444832 | 1.0 | MAP2K5 MAPK7 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:05418 | 0.0011031979467 | 1.0 | MAP2K5 MAPK7 | Fluid shear stress and atherosclerosis |
| KEGG:04921 | 0.00112221860095 | 1.0 | MAP2K5 MAPK7 | Oxytocin signaling pathway |
| WP:WP185 | 0.00148377064565 | 1.0 | MAP2K5 MAPK7 | Integrin mediated cell adhesion |
| WP:WP3931 | 0.00210690324038 | 1.0 | MAP2K5 MAPK7 | Embryonic stem cell pluripotency pathways |
| WP:WP3915 | 0.0027415280346 | 1.0 | MAP2K5 MAPK7 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP2380 | 0.00319355454799 | 1.0 | MAP2K5 MAPK7 | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP481 | 0.00432149264637 | 1.0 | MAP2K5 MAPK7 | Insulin signaling |
| WP:WP437 | 0.00438235873998 | 1.0 | MAP2K5 MAPK7 | EGF EGFR signaling pathway |
| GO:0071499 | 0.00468200720083 | 1.0 | MAP2K5 MAPK7 | cellular response to laminar fluid shear stress |
| KEGG:04010 | 0.0047800367266 | 1.0 | MAP2K5 MAPK7 | MAPK signaling pathway |
| GO:0034616 | 0.00702301080125 | 1.0 | MAP2K5 MAPK7 | response to laminar fluid shear stress |
| REAC:R-HSA-187037 | 0.00795599471791 | 1.0 | MAP2K5 MAPK7 | Signaling by NTRK1 (TRKA) |
| WP:WP382 | 0.00855530406698 | 1.0 | MAP2K5 MAPK7 | MAPK signaling pathway |
| REAC:R-HSA-166520 | 0.0110061344455 | 1.0 | MAP2K5 MAPK7 | Signaling by NTRKs |
| GO:0034115 | 0.016855225923 | 1.0 | MAP2K5 MAPK7 | negative regulation of heterotypic cell-cell adhesion |
| GO:0070587 | 0.016855225923 | 1.0 | MAP2K5 MAPK7 | regulation of cell-cell adhesion involved in gastrulation |
| GO:0070586 | 0.016855225923 | 1.0 | MAP2K5 MAPK7 | cell-cell adhesion involved in gastrulation |
| GO:0071498 | 0.016855225923 | 1.0 | MAP2K5 MAPK7 | cellular response to fluid shear stress |
| WP:WP5087 | 0.0293715080819 | 1.0 | MAP2K5 MAPK7 | Pleural mesothelioma |
| GO:0034405 | 0.0365196561665 | 1.0 | MAP2K5 MAPK7 | response to fluid shear stress |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP2K5 | MAPK7 | 0.996 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| MAP2K5 | huMAP3_02733.1 huMAP3_03261.1 huMAP3_03708.1 huMAP3_10808.1 huMAP3_10861.1 |
| MAPK7 | huMAP3_02733.1 huMAP3_03261.1 huMAP3_10861.1 |