hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03271.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPTOR | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | 5 | UniProt NCBI |
| RRAGA | Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1) | 5 | UniProt NCBI |
| LAMTOR4 | Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed] | 5 | UniProt NCBI |
| LAMTOR3 | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) | 5 | UniProt NCBI |
| LAMTOR5 | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | 5 | UniProt NCBI |
| RRAGB | Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-166208 | 1.82986319898e-15 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | mTORC1-mediated signalling |
| REAC:R-HSA-380972 | 6.45800482018e-15 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 6.11294163981e-14 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | MTOR signalling |
| REAC:R-HSA-9639288 | 3.12112156329e-13 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Amino acids regulate mTORC1 |
| REAC:R-HSA-8943724 | 4.93347030298e-13 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Regulation of PTEN gene transcription |
| REAC:R-HSA-5628897 | 3.77896585315e-12 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | TP53 Regulates Metabolic Genes |
| GO:0071230 | 4.97332291692e-12 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to amino acid stimulus |
| GO:0071229 | 8.59682292869e-12 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to acid chemical |
| GO:0043200 | 1.20648594511e-11 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to amino acid |
| GO:0001101 | 2.25440881952e-11 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to acid chemical |
| KEGG:04150 | 5.04248004732e-11 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | mTOR signaling pathway |
| REAC:R-HSA-1632852 | 6.69586253065e-11 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Macroautophagy |
| REAC:R-HSA-6807070 | 1.0212516238e-10 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | PTEN Regulation |
| REAC:R-HSA-9612973 | 1.33215415472e-10 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Autophagy |
| REAC:R-HSA-9711097 | 2.19333607619e-10 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Cellular response to starvation |
| GO:0032008 | 3.05442546692e-10 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | positive regulation of TOR signaling |
| GO:0038202 | 2.14887657454e-09 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | TORC1 signaling |
| REAC:R-HSA-1257604 | 2.61739309821e-09 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 6.17695829337e-09 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Intracellular signaling by second messengers |
| GO:0032006 | 1.65128897823e-08 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | regulation of TOR signaling |
| REAC:R-HSA-3700989 | 2.69262180848e-08 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Transcriptional Regulation by TP53 |
| GO:0031929 | 3.17725189114e-08 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | TOR signaling |
| GO:1990877 | 8.28303368884e-08 | 0.666666666667 | LAMTOR5 LAMTOR4 RRAGA LAMTOR3 | FNIP-folliculin RagC/D GAP |
| GO:1904263 | 1.14175047996e-07 | 0.833333333333 | LAMTOR5 LAMTOR4 RRAGB RRAGA LAMTOR3 | positive regulation of TORC1 signaling |
| GO:1902773 | 1.30147699894e-07 | 0.666666666667 | LAMTOR5 LAMTOR4 RRAGA LAMTOR3 | GTPase activator complex |
| GO:0150005 | 7.17391174374e-07 | 0.666666666667 | LAMTOR5 LAMTOR4 RRAGA LAMTOR3 | enzyme activator complex |
| CORUM:6888 | 1.69968198401e-06 | 0.5 | LAMTOR4 LAMTOR5 LAMTOR3 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| GO:1903432 | 1.7640596292e-06 | 0.833333333333 | LAMTOR5 LAMTOR4 RRAGB RRAGA LAMTOR3 | regulation of TORC1 signaling |
| REAC:R-HSA-2262752 | 2.64149968796e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Cellular responses to stress |
| REAC:R-HSA-8953897 | 2.79926993011e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Cellular responses to stimuli |
| GO:0005765 | 5.88616286932e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | lysosomal membrane |
| GO:0098852 | 5.88616286932e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | lytic vacuole membrane |
| GO:0071417 | 6.81537085513e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to organonitrogen compound |
| GO:0005774 | 9.35997841262e-06 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | vacuolar membrane |
| GO:1901699 | 1.46280336928e-05 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to nitrogen compound |
| WP:WP1471 | 1.64258598412e-05 | 0.5 | RPTOR RRAGA RRAGB | Target of rapamycin signaling |
| REAC:R-HSA-212436 | 2.1578946509e-05 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Generic Transcription Pathway |
| GO:0071986 | 3.84302573496e-05 | 0.5 | LAMTOR4 LAMTOR5 LAMTOR3 | Ragulator complex |
| REAC:R-HSA-73857 | 4.17740470622e-05 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | RNA Polymerase II Transcription |
| GO:0010243 | 4.6478203476e-05 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to organonitrogen compound |
| REAC:R-HSA-74160 | 8.88513506469e-05 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Gene expression (Transcription) |
| GO:1901698 | 0.000109395490892 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to nitrogen compound |
| GO:0000323 | 0.000177070043467 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | lytic vacuole |
| GO:0005764 | 0.000177070043467 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | lysosome |
| GO:0005773 | 0.000316551917827 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | vacuole |
| GO:1901701 | 0.000411170968199 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to oxygen-containing compound |
| GO:1902533 | 0.000617295553083 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | positive regulation of intracellular signal transduction |
| KEGG:04140 | 0.00120621676501 | 0.5 | RPTOR RRAGA RRAGB | Autophagy - animal |
| REAC:R-HSA-162582 | 0.00128853291586 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | Signal Transduction |
| GO:1901700 | 0.00155564667877 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to oxygen-containing compound |
| GO:0032045 | 0.00185822071527 | 0.5 | LAMTOR4 LAMTOR5 LAMTOR3 | guanyl-nucleotide exchange factor complex |
| GO:0071495 | 0.00193018044108 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to endogenous stimulus |
| GO:0009719 | 0.00322757972864 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to endogenous stimulus |
| KEGG:05131 | 0.00369808394071 | 0.5 | RPTOR RRAGA RRAGB | Shigellosis |
| HPA:0570741 | 0.00422505994474 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | testis; cells in seminiferous ducts[>=Low] |
| GO:0009967 | 0.00644255832273 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | positive regulation of signal transduction |
| GO:0071310 | 0.00868484611575 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cellular response to organic substance |
| GO:0010647 | 0.0107782253297 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | positive regulation of cell communication |
| GO:0023056 | 0.0110671698551 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | positive regulation of signaling |
| GO:1902531 | 0.0167276191802 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | regulation of intracellular signal transduction |
| HPA:0630052 | 0.02278471139 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cervix; glandular cells[>=Medium] |
| HPA:0090162 | 0.0260213768635 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | cerebellum; Purkinje cells[>=Medium] |
| HPA:0250132 | 0.0311695988487 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | hippocampus; neuronal cells[>=Medium] |
| HPA:0241102 | 0.035034386841 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | heart muscle; cardiomyocytes[>=Medium] |
| GO:0010033 | 0.0366453483103 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | response to organic substance |
| GO:0061462 | 0.037407051376 | 0.5 | LAMTOR4 RRAGA LAMTOR5 | protein localization to lysosome |
| HPA:0360052 | 0.0400703067036 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | parathyroid gland; glandular cells[>=Medium] |
| GO:1990131 | 0.042122686785 | 0.333333333333 | RRAGA RRAGB | Gtr1-Gtr2 GTPase complex |
| GO:0098588 | 0.046464555054 | 1.0 | LAMTOR4 RPTOR LAMTOR5 RRAGB LAMTOR3 RRAGA | bounding membrane of organelle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RRAGA | LAMTOR5 | 0.999 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LAMTOR4 | LAMTOR5 | 0.998 | 0.582 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LAMTOR4 | LAMTOR3 | 0.998 | 0.912 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGB | LAMTOR4 | 0.998 | 0.34 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LAMTOR3 | LAMTOR5 | 0.997 | 0.332 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGA | LAMTOR3 | 0.994 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RRAGB | LAMTOR3 | 0.992 | 0.232 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGB | RPTOR | 0.989 | 0.068 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGA | LAMTOR4 | 0.988 | 0.266 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPTOR | RRAGA | 0.988 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RPTOR | LAMTOR4 | 0.986 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPTOR | LAMTOR5 | 0.981 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPTOR | LAMTOR3 | 0.965 | 0.052 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGB | LAMTOR5 | 0.923 | 0.134 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RRAGB | RRAGA | 0.634 | 0.348 | bioplex3_WMM WMM_only |
Related Complexes