hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03275.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HPS5 | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | 5 | UniProt NCBI |
| HPS6 | BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru) | 5 | UniProt NCBI |
| HPS3 | BLOC-2 complex member HPS3 (Hermansky-Pudlak syndrome 3 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:12 | 2.33868713081e-10 | 1.0 | HPS3 HPS5 HPS6 | BLOC-2 (biogenesis of lysosome-related organelles complex 2) |
| CORUM:654 | 3.85883376584e-08 | 1.0 | HPS3 HPS5 HPS6 | BLOC1-BLOC2 complex |
| GO:0031084 | 9.61200410764e-08 | 1.0 | HPS3 HPS5 HPS6 | BLOC-2 complex |
| HP:0011883 | 1.42881142141e-07 | 1.0 | HPS3 HPS5 HPS6 | Abnormal platelet granules |
| HP:0001022 | 4.84929936962e-07 | 1.0 | HPS3 HPS5 HPS6 | Albinism |
| HP:0007513 | 2.25146042161e-06 | 1.0 | HPS3 HPS5 HPS6 | Generalized hypopigmentation |
| HP:0003540 | 3.16416783868e-06 | 1.0 | HPS3 HPS5 HPS6 | Impaired platelet aggregation |
| HP:0030402 | 3.89242869044e-06 | 1.0 | HPS3 HPS5 HPS6 | Abnormal platelet aggregation |
| HP:0011869 | 1.4041319514e-05 | 1.0 | HPS3 HPS5 HPS6 | Abnormal platelet function |
| HP:0000421 | 6.58777319363e-05 | 1.0 | HPS3 HPS5 HPS6 | Epistaxis |
| HP:0005599 | 7.66882057453e-05 | 1.0 | HPS3 HPS5 HPS6 | Hypopigmentation of hair |
| GO:1903232 | 7.84339535184e-05 | 1.0 | HPS3 HPS5 HPS6 | melanosome assembly |
| GO:0031082 | 9.31403198031e-05 | 1.0 | HPS3 HPS5 HPS6 | BLOC complex |
| HP:0012530 | 0.000126523416231 | 0.666666666667 | HPS5 HPS3 | Abnormal number of dense granules |
| GO:0060155 | 0.000127839654632 | 1.0 | HPS3 HPS5 HPS6 | platelet dense granule organization |
| HP:0009887 | 0.000144309953562 | 1.0 | HPS3 HPS5 HPS6 | Abnormality of hair pigmentation |
| HP:0012484 | 0.000189776464884 | 0.666666666667 | HPS5 HPS3 | Abnormal dense granules |
| HP:0000978 | 0.000458428515907 | 1.0 | HPS3 HPS5 HPS6 | Bruising susceptibility |
| HP:0004866 | 0.000569225481094 | 0.666666666667 | HPS5 HPS6 | Impaired ADP-induced platelet aggregation |
| GO:0032438 | 0.000686297093286 | 1.0 | HPS3 HPS5 HPS6 | melanosome organization |
| GO:0048753 | 0.000686297093286 | 1.0 | HPS3 HPS5 HPS6 | pigment granule organization |
| GO:0033363 | 0.000810868666521 | 1.0 | HPS3 HPS5 HPS6 | secretory granule organization |
| HP:0001010 | 0.000899042784202 | 1.0 | HPS3 HPS5 HPS6 | Hypopigmentation of the skin |
| HP:0001933 | 0.00141439774498 | 1.0 | HPS3 HPS5 HPS6 | Subcutaneous hemorrhage |
| GO:0033059 | 0.00252170927764 | 1.0 | HPS3 HPS5 HPS6 | cellular pigmentation |
| HP:0001107 | 0.00265505202111 | 0.666666666667 | HPS5 HPS6 | Ocular albinism |
| GO:0043473 | 0.00597828207479 | 1.0 | HPS3 HPS5 HPS6 | pigmentation |
| HP:0008059 | 0.0075178385046 | 0.666666666667 | HPS5 HPS6 | Aplasia/Hypoplasia of the macula |
| HP:0011875 | 0.00785695607115 | 1.0 | HPS3 HPS5 HPS6 | Abnormal platelet morphology |
| HP:0008061 | 0.00795970060154 | 0.666666666667 | HPS5 HPS6 | Aplasia/Hypoplasia of the retina |
| HP:0003010 | 0.00888120343534 | 0.666666666667 | HPS5 HPS6 | Prolonged bleeding time |
| HP:0001872 | 0.00923670297429 | 1.0 | HPS3 HPS5 HPS6 | Abnormality of thrombocytes |
| HP:0001000 | 0.0107692028076 | 1.0 | HPS3 HPS5 HPS6 | Abnormality of skin pigmentation |
| HP:0000493 | 0.0108752751697 | 0.666666666667 | HPS5 HPS6 | Abnormal foveal morphology |
| HP:0001892 | 0.0128902136124 | 1.0 | HPS3 HPS5 HPS6 | Abnormal bleeding |
| HP:0007730 | 0.0136509708315 | 0.666666666667 | HPS5 HPS6 | Iris hypopigmentation |
| HP:0007663 | 0.0168758042713 | 1.0 | HPS3 HPS5 HPS6 | Reduced visual acuity |
| HP:0011276 | 0.0177176911348 | 1.0 | HPS3 HPS5 HPS6 | Vascular skin abnormality |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HPS6 | HPS3 | 0.999 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HPS5 | HPS6 | 0.999 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HPS5 | HPS3 | 0.999 | 0.094 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| HPS5 | huMAP3_02706.1 huMAP3_03275.1 huMAP3_08447.1 huMAP3_08728.1 huMAP3_09141.1 huMAP3_13683.1 |
| HPS6 | huMAP3_02706.1 huMAP3_03275.1 |
| HPS3 | huMAP3_03275.1 |