hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_03276.1

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
ERBB3	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)	5	UniProt NCBI
GLOD4	Glyoxalase domain-containing protein 4	4	UniProt NCBI
NRG1	Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]	5	UniProt NCBI
TMEM39B	Transmembrane protein 39B	3	UniProt NCBI

Showing 1 to 4 of 4 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2864	0.002406667175	0.5	ERBB3 NRG1	Apoptosis related network due to altered Notch3 in ovarian cancer
KEGG:01521	0.00673027197618	0.5	ERBB3 NRG1	EGFR tyrosine kinase inhibitor resistance
KEGG:04012	0.00710024614077	0.5	ERBB3 NRG1	ErbB signaling pathway
WP:WP4806	0.00781315318354	0.5	ERBB3 NRG1	EGFR tyrosine kinase inhibitor resistance
WP:WP673	0.00821485966847	0.5	ERBB3 NRG1	ErbB signaling pathway
GO:0043125	0.0280843539964	0.5	ERBB3 NRG1	ErbB-3 class receptor binding
CORUM:5441	0.049938562206	0.25	NRG1	NRG1-IKZF4 complex
CORUM:6505	0.049938562206	0.25	ERBB3	ERBB3-SPG1 complex

Showing 1 to 8 of 8 entries

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
ERBB3	NRG1	0.996		bioplex3_WMM bioplex3_HCT116 WMM_only
GLOD4	NRG1	0.978		bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM39B	NRG1	0.976		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TMEM39B	ERBB3	0.042	0.06	bioplex3_WMM WMM_only
GLOD4	ERBB3	0.005		bioplex3_HCT116 WMM_only
TMEM39B	GLOD4	0.002		bioplex3_HCT116 WMM_only

Showing 1 to 6 of 6 entries

Related Complexes

Genename	Complexes
TMEM39B	huMAP3_02076.1 huMAP3_03276.1 huMAP3_07557.1
GLOD4	huMAP3_02374.1 huMAP3_03276.1 huMAP3_13697.1 huMAP3_14870.1
ERBB3	huMAP3_02374.1 huMAP3_03276.1 huMAP3_11283.1 huMAP3_14574.1
NRG1	huMAP3_02374.1 huMAP3_03276.1 huMAP3_07557.1