hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03281.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EMC6 | ER membrane protein complex subunit 6 (Transmembrane protein 93) | 5 | UniProt NCBI |
| EMC4 | ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85) | 5 | UniProt NCBI |
| EMC7 | Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7) | 5 | UniProt NCBI |
| EMC9 | ER membrane protein complex subunit 9 (Protein FAM158A) | 4 | UniProt NCBI |
| EMC1 | ER membrane protein complex subunit 1 | 5 | UniProt NCBI |
| EMC8 | ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) | 5 | UniProt NCBI |
| EMC2 | ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) | 5 | UniProt NCBI |
| EMC10 | ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) | 5 | UniProt NCBI |
| EMC3 | ER membrane protein complex subunit 3 (Transmembrane protein 111) | 5 | UniProt NCBI |
| NADSYN1 | Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072546 | 5.97842616607e-26 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | EMC complex |
| GO:0045050 | 3.2879317689e-25 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein insertion into ER membrane by stop-transfer membrane-anchor sequence |
| GO:0032977 | 6.83679080597e-23 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | membrane insertase activity |
| GO:0071816 | 1.45272848715e-22 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | tail-anchored membrane protein insertion into ER membrane |
| GO:0045048 | 5.98038660732e-20 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein insertion into ER membrane |
| GO:0140597 | 8.54288235729e-20 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein carrier chaperone |
| GO:0051205 | 9.72871536058e-19 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein insertion into membrane |
| GO:0007029 | 1.2251972299e-15 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endoplasmic reticulum organization |
| GO:0140104 | 1.38041848791e-15 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | molecular carrier activity |
| GO:0140534 | 1.78602842961e-14 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endoplasmic reticulum protein-containing complex |
| GO:0090150 | 1.03977629069e-11 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | establishment of protein localization to membrane |
| GO:0010256 | 8.58153354875e-09 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endomembrane system organization |
| GO:0072657 | 1.05325986162e-08 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein localization to membrane |
| GO:0051668 | 4.99920109885e-08 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | localization within membrane |
| GO:0061024 | 8.75659409748e-08 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | membrane organization |
| GO:0005789 | 6.28257785091e-07 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endoplasmic reticulum membrane |
| GO:0098827 | 7.22539559195e-07 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endoplasmic reticulum subcompartment |
| GO:0042175 | 7.7908749877e-07 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0033365 | 9.2658176879e-07 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein localization to organelle |
| GO:0098796 | 7.26942127428e-06 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | membrane protein complex |
| GO:0031984 | 8.5636928257e-06 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | organelle subcompartment |
| GO:0045184 | 1.51911761247e-05 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | establishment of protein localization |
| GO:0005783 | 0.000270206972234 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | endoplasmic reticulum |
| GO:0008104 | 0.00132771475498 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | protein localization |
| GO:0070727 | 0.00135662935195 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | cellular macromolecule localization |
| GO:0033036 | 0.00570021213464 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | macromolecule localization |
| GO:0051641 | 0.0345887146099 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | cellular localization |
| GO:0031090 | 0.0481586078992 | 0.9 | EMC3 EMC7 EMC8 EMC1 EMC6 EMC9 EMC4 EMC10 EMC2 | organelle membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EMC7 | EMC3 | 1.0 | 0.956 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC1 | EMC10 | 1.0 | 0.59 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC3 | 1.0 | 0.8 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC10 | EMC3 | 1.0 | 0.838 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC1 | EMC2 | 1.0 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC1 | 1.0 | 0.716 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC1 | EMC3 | 1.0 | 0.882 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC2 | 1.0 | 0.43 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC10 | 1.0 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC1 | EMC8 | 1.0 | 0.636 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC8 | EMC2 | 1.0 | 0.894 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC2 | EMC10 | 1.0 | 0.73 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC2 | 1.0 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC2 | EMC3 | 1.0 | 0.936 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC7 | EMC8 | 1.0 | 0.77 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC7 | EMC9 | 1.0 | 0.328 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC9 | 1.0 | 0.222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC7 | 1.0 | 0.532 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC1 | 1.0 | 0.258 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC8 | EMC3 | 1.0 | 0.706 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC7 | EMC10 | 1.0 | 0.888 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC2 | 1.0 | 0.668 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC4 | EMC8 | 1.0 | 0.324 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC7 | EMC1 | 1.0 | 0.89 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| EMC6 | EMC9 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC10 | 1.0 | 0.206 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC9 | EMC3 | 1.0 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EMC7 | EMC2 | 1.0 | 0.854 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC4 | 0.999 | 0.172 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC7 | 0.999 | 0.32 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC8 | 0.999 | 0.338 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC6 | EMC1 | 0.999 | 0.374 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| EMC6 | EMC3 | 0.999 | 0.364 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| EMC8 | EMC10 | 0.999 | 0.546 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC4 | EMC10 | 0.998 | 0.56 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC6 | NADSYN1 | 0.996 | 0.03 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| EMC9 | EMC8 | 0.971 | 0.288 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EMC2 | NADSYN1 | 0.971 | 0.04 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EMC3 | NADSYN1 | 0.745 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only |
| EMC4 | NADSYN1 | 0.725 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only |
| EMC8 | NADSYN1 | 0.716 | 0.016 | bioplex_WMM bioplex3_WMM WMM_only |
| EMC7 | NADSYN1 | 0.685 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only |
| EMC9 | NADSYN1 | 0.6 | 0.03 | bioplex3_WMM WMM_only |
| EMC10 | NADSYN1 | 0.58 | 0.012 | bioplex3_WMM WMM_only |
| EMC1 | NADSYN1 | 0.551 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes