hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03298.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP5F1C | ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) | 5 | UniProt NCBI |
| ATP5F1E | ATP synthase subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon) | 5 | UniProt NCBI |
| ATP5PO | ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:563 | 5.14511168779e-08 | 1.0 | ATP5F1C ATP5F1E ATP5PO | F1F0-ATP synthase, mitochondrial |
| REAC:R-HSA-163210 | 3.80747347177e-07 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Formation of ATP by chemiosmotic coupling |
| REAC:R-HSA-8949613 | 1.89440469306e-06 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Cristae formation |
| GO:0045261 | 1.92240082153e-06 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton-transporting ATP synthase complex, catalytic core F(1) |
| WP:WP111 | 1.17898981996e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Oxidative phosphorylation |
| REAC:R-HSA-1592230 | 4.77520631251e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Mitochondrial biogenesis |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Diabetic cardiomyopathy |
| GO:0046933 | 5.38272230028e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton-transporting ATP synthase activity, rotational mechanism |
| GO:0033178 | 6.5361627932e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton-transporting two-sector ATPase complex, catalytic domain |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Prion disease |
| GO:0045259 | 0.000127839654632 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton-transporting ATP synthase complex |
| GO:0005753 | 0.000127839654632 | 1.0 | ATP5F1C ATP5F1E ATP5PO | mitochondrial proton-transporting ATP synthase complex |
| GO:0015252 | 0.000127839654632 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton channel activity |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Alzheimer disease |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | ATP5F1C ATP5F1E ATP5PO | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Pathways of neurodegeneration - multiple diseases |
| GO:0016469 | 0.00127301382402 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton-transporting two-sector ATPase complex |
| REAC:R-HSA-1852241 | 0.00159971044576 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Organelle biogenesis and maintenance |
| WP:WP623 | 0.00193308448658 | 0.666666666667 | ATP5F1E ATP5PO | Oxidative phosphorylation |
| GO:0042776 | 0.00381702295119 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton motive force-driven mitochondrial ATP synthesis |
| WP:WP4932 | 0.00514316015145 | 0.666666666667 | ATP5F1E ATP5PO | 7q11 23 copy number variation syndrome |
| GO:0015986 | 0.00526161104852 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton motive force-driven ATP synthesis |
| GO:0006754 | 0.00851239083773 | 1.0 | ATP5F1C ATP5F1E ATP5PO | ATP biosynthetic process |
| GO:0009206 | 0.00915870199393 | 1.0 | ATP5F1C ATP5F1E ATP5PO | purine ribonucleoside triphosphate biosynthetic process |
| GO:0009145 | 0.00915870199393 | 1.0 | ATP5F1C ATP5F1E ATP5PO | purine nucleoside triphosphate biosynthetic process |
| GO:0009201 | 0.0109157763448 | 1.0 | ATP5F1C ATP5F1E ATP5PO | ribonucleoside triphosphate biosynthetic process |
| GO:0009142 | 0.0120707547584 | 1.0 | ATP5F1C ATP5F1E ATP5PO | nucleoside triphosphate biosynthetic process |
| GO:0015078 | 0.0120707547584 | 1.0 | ATP5F1C ATP5F1E ATP5PO | proton transmembrane transporter activity |
| GO:0000275 | 0.0140440992017 | 0.666666666667 | ATP5F1C ATP5F1E | mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) |
| KEGG:01100 | 0.0189521995452 | 1.0 | ATP5F1C ATP5F1E ATP5PO | Metabolic pathways |
| GO:0006119 | 0.025655976884 | 1.0 | ATP5F1C ATP5F1E ATP5PO | oxidative phosphorylation |
| GO:1904949 | 0.042099520671 | 1.0 | ATP5F1C ATP5F1E ATP5PO | ATPase complex |
| GO:0016874 | 0.0449053607901 | 1.0 | ATP5F1C ATP5F1E ATP5PO | ligase activity |
| GO:0098800 | 0.0498541011049 | 1.0 | ATP5F1C ATP5F1E ATP5PO | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATP5PO | ATP5F1C | 1.0 | 0.974 |
structurally_consistent (P25705)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| ATP5PO | ATP5F1E | 0.997 | 0.714 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| ATP5F1C | ATP5F1E | 0.994 | 0.762 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
Related Complexes