hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_03331.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5624958 | 5.12628525639e-06 | 1.0 | PDE6D INPP5E | ARL13B-mediated ciliary trafficking of INPP5E |
| CORUM:6741 | 5.12628525639e-06 | 1.0 | PDE6D INPP5E | INPP5E-PDE6D-RPGR complex |
| HP:0002335 | 0.000266566833332 | 1.0 | PDE6D INPP5E | Agenesis of cerebellar vermis |
| HP:0007973 | 0.000943236487175 | 1.0 | PDE6D INPP5E | Retinal dysplasia |
| WP:WP4656 | 0.00105770799037 | 1.0 | PDE6D INPP5E | Joubert syndrome |
| WP:WP5234 | 0.00121306550203 | 1.0 | PDE6D INPP5E | Bardet Biedl syndrome |
| REAC:R-HSA-5620920 | 0.00176856841345 | 1.0 | PDE6D INPP5E | Cargo trafficking to the periciliary membrane |
| HP:0002419 | 0.00191723068589 | 1.0 | PDE6D INPP5E | Molar tooth sign on MRI |
| HP:0002876 | 0.00401900764101 | 1.0 | PDE6D INPP5E | Episodic tachypnea |
| WP:WP4803 | 0.00514595155073 | 1.0 | PDE6D INPP5E | Ciliopathies |
| HP:0004422 | 0.0054543675128 | 1.0 | PDE6D INPP5E | Biparietal narrowing |
| HP:0001830 | 0.00667442340382 | 1.0 | PDE6D INPP5E | Postaxial foot polydactyly |
| HP:0002418 | 0.00801751014099 | 1.0 | PDE6D INPP5E | Abnormal midbrain morphology |
| HP:0001162 | 0.0110727761538 | 1.0 | PDE6D INPP5E | Postaxial hand polydactyly |
| HP:0010322 | 0.0110727761538 | 1.0 | PDE6D INPP5E | Abnormal fifth toe morphology |
| HP:0002789 | 0.011629832485 | 1.0 | PDE6D INPP5E | Tachypnea |
| HP:0001696 | 0.0146201655512 | 1.0 | PDE6D INPP5E | Situs inversus totalis |
| HP:0011534 | 0.0152592424465 | 1.0 | PDE6D INPP5E | Abnormal spatial orientation of the cardiac segments |
| HP:0000657 | 0.0162434892157 | 1.0 | PDE6D INPP5E | Oculomotor apraxia |
| HP:0011815 | 0.0183042558888 | 1.0 | PDE6D INPP5E | Cephalocele |
| HP:0002084 | 0.0183042558888 | 1.0 | PDE6D INPP5E | Encephalocele |
| HP:0001651 | 0.0208639809935 | 1.0 | PDE6D INPP5E | Dextrocardia |
| HP:0004307 | 0.0212433261025 | 1.0 | PDE6D INPP5E | Abnormal anatomic location of the heart |
| HP:0001829 | 0.0231913144999 | 1.0 | PDE6D INPP5E | Foot polydactyly |
| HP:0009136 | 0.0248112206409 | 1.0 | PDE6D INPP5E | Duplication involving bones of the feet |
| HP:0100259 | 0.026912997596 | 1.0 | PDE6D INPP5E | Postaxial polydactyly |
| HP:0034237 | 0.0273436055576 | 1.0 | PDE6D INPP5E | Open neural tube defect |
| HP:0004362 | 0.0299990213204 | 1.0 | PDE6D INPP5E | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.0299990213204 | 1.0 | PDE6D INPP5E | Aganglionic megacolon |
| REAC:R-HSA-5617833 | 0.0303578612883 | 1.0 | PDE6D INPP5E | Cilium Assembly |
| HP:0012331 | 0.0304535519464 | 1.0 | PDE6D INPP5E | Abnormal autonomic nervous system morphology |
| HP:0025028 | 0.0304535519464 | 1.0 | PDE6D INPP5E | Abnormal enteric nervous system morphology |
| HP:0001161 | 0.0418509928331 | 1.0 | PDE6D INPP5E | Hand polydactyly |
| HP:0000612 | 0.0440177027348 | 1.0 | PDE6D INPP5E | Iris coloboma |
| CORUM:6740 | 0.0499419797295 | 0.5 | INPP5E | AURKA-INPP5E complex |
| HP:0007271 | 0.0499436884913 | 0.5 | INPP5E | Occipital myelomeningocele |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE6D | INPP5E | 0.998 | bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
Related Complexes