hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03347.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GBA1 | Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Beta-glucosylceramidase 1) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Glucosylceramidase beta 1) (Imiglucerase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase) | 5 | UniProt NCBI |
| SCARB2 | Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005230 | 3.41752350426e-06 | 1.0 | GBA1 SCARB2 | Biliary tract obstruction |
| HP:0003656 | 3.41752350426e-06 | 1.0 | GBA1 SCARB2 | Decreased beta-glucocerebrosidase level |
| HP:0032640 | 3.41752350426e-06 | 1.0 | GBA1 SCARB2 | Elevated circulating CCL18 level |
| HP:0031830 | 3.41752350426e-06 | 1.0 | GBA1 SCARB2 | Pinguecula |
| HP:0012223 | 3.41752350426e-05 | 1.0 | GBA1 SCARB2 | Splenic rupture |
| HP:0034336 | 5.12628525639e-05 | 1.0 | GBA1 SCARB2 | Splenic infarction |
| WP:WP4153 | 5.7886634483e-05 | 1.0 | GBA1 SCARB2 | Degradation pathway of sphingolipids including diseases |
| HP:0006775 | 9.56906581192e-05 | 1.0 | GBA1 SCARB2 | Multiple myeloma |
| HP:0004975 | 9.56906581192e-05 | 1.0 | GBA1 SCARB2 | Erlenmeyer flask deformity of the femurs |
| HP:0025409 | 0.000522881096151 | 1.0 | GBA1 SCARB2 | Abnormal spleen physiology |
| HP:0001971 | 0.000522881096151 | 1.0 | GBA1 SCARB2 | Hypersplenism |
| KEGG:04142 | 0.00121976041763 | 1.0 | GBA1 SCARB2 | Lysosome |
| HP:0002176 | 0.00169509165811 | 1.0 | GBA1 SCARB2 | Spinal cord compression |
| HP:0002953 | 0.00227607065384 | 1.0 | GBA1 SCARB2 | Vertebral compression fracture |
| HP:0003281 | 0.00240251902349 | 1.0 | GBA1 SCARB2 | Increased circulating ferritin concentration |
| HP:0040133 | 0.00253238491666 | 1.0 | GBA1 SCARB2 | Abnormal circulating ferritin concentration |
| HP:0003233 | 0.00323297723503 | 1.0 | GBA1 SCARB2 | Decreased HDL cholesterol concentration |
| HP:0002758 | 0.00338334826922 | 1.0 | GBA1 SCARB2 | Osteoarthritis |
| HP:0031888 | 0.00353713682691 | 1.0 | GBA1 SCARB2 | Abnormal HDL cholesterol concentration |
| HP:0000225 | 0.00353713682691 | 1.0 | GBA1 SCARB2 | Gingival bleeding |
| HP:0002756 | 0.00435734246793 | 1.0 | GBA1 SCARB2 | Pathologic fracture |
| HP:0010981 | 0.00470934738887 | 1.0 | GBA1 SCARB2 | Hypolipoproteinemia |
| HP:0001409 | 0.00625406801279 | 1.0 | GBA1 SCARB2 | Portal hypertension |
| HP:0001081 | 0.00710844888886 | 1.0 | GBA1 SCARB2 | Cholelithiasis |
| HP:0012440 | 0.0077851185427 | 1.0 | GBA1 SCARB2 | Abnormal biliary tract morphology |
| HPA:0381223 | 0.0078480791653 | 1.0 | GBA1 SCARB2 | placenta; syncytiotrophoblasts - microvilli[High] |
| HP:0002653 | 0.00801751014099 | 1.0 | GBA1 SCARB2 | Bone pain |
| HP:0006707 | 0.00873519007688 | 1.0 | GBA1 SCARB2 | Abnormality of the hepatic vasculature |
| HP:0002070 | 0.00873519007688 | 1.0 | GBA1 SCARB2 | Limb ataxia |
| HP:0010979 | 0.00898125176919 | 1.0 | GBA1 SCARB2 | Abnormality of lipoprotein cholesterol concentration |
| HP:0012437 | 0.009230730985 | 1.0 | GBA1 SCARB2 | Abnormal gallbladder morphology |
| HP:0002797 | 0.0102628230833 | 1.0 | GBA1 SCARB2 | Osteolysis |
| HP:0010885 | 0.0107993742735 | 1.0 | GBA1 SCARB2 | Avascular necrosis |
| HP:0001080 | 0.0107993742735 | 1.0 | GBA1 SCARB2 | Biliary tract abnormality |
| HP:0010702 | 0.011629832485 | 1.0 | GBA1 SCARB2 | Increased circulating antibody level |
| HP:0007141 | 0.011629832485 | 1.0 | GBA1 SCARB2 | Sensorimotor neuropathy |
| HP:0005264 | 0.0133830220427 | 1.0 | GBA1 SCARB2 | Abnormality of the gallbladder |
| HPA:0461421 | 0.0161258438244 | 1.0 | GBA1 SCARB2 | skin 1; eccrine glands[>=Low] |
| HP:0002039 | 0.0165784065192 | 1.0 | GBA1 SCARB2 | Anorexia |
| HP:0001541 | 0.0193807757926 | 1.0 | GBA1 SCARB2 | Ascites |
| HP:0001876 | 0.0208639809935 | 1.0 | GBA1 SCARB2 | Pancytopenia |
| HPA:0381203 | 0.0220168680517 | 1.0 | GBA1 SCARB2 | placenta; hofbauer cells[High] |
| HPA:0381222 | 0.0223436456751 | 1.0 | GBA1 SCARB2 | placenta; syncytiotrophoblasts - microvilli[>=Medium] |
| HPA:0471393 | 0.0240136418168 | 1.0 | GBA1 SCARB2 | skin 2; cells in basal layer[High] |
| HP:0001300 | 0.0252247409849 | 1.0 | GBA1 SCARB2 | Parkinsonism |
| HP:0033578 | 0.0260620342435 | 1.0 | GBA1 SCARB2 | Pre-capillary pulmonary hypertension |
| HP:0002092 | 0.0260620342435 | 1.0 | GBA1 SCARB2 | Pulmonary arterial hypertension |
| HP:0004890 | 0.026485807158 | 1.0 | GBA1 SCARB2 | Elevated pulmonary artery pressure |
| HPA:0460203 | 0.0268108101291 | 1.0 | GBA1 SCARB2 | skin 1; endothelial cells[High] |
| HP:0006530 | 0.026912997596 | 1.0 | GBA1 SCARB2 | Abnormal pulmonary interstitial morphology |
| HPA:0470203 | 0.0271712885755 | 1.0 | GBA1 SCARB2 | skin 2; endothelial cells[High] |
| HP:0003107 | 0.0273436055576 | 1.0 | GBA1 SCARB2 | Abnormal circulating cholesterol concentration |
| HP:0033331 | 0.0291002126388 | 1.0 | GBA1 SCARB2 | Acute phase response |
| HP:0001394 | 0.0304535519464 | 1.0 | GBA1 SCARB2 | Cirrhosis |
| HPA:0381221 | 0.0305239186675 | 1.0 | GBA1 SCARB2 | placenta; syncytiotrophoblasts - microvilli[>=Low] |
| HPA:0381213 | 0.0307158929988 | 1.0 | GBA1 SCARB2 | placenta; syncytiotrophoblasts - cell body[High] |
| HP:0001433 | 0.030911500096 | 1.0 | GBA1 SCARB2 | Hepatosplenomegaly |
| HP:0001882 | 0.0313728657691 | 1.0 | GBA1 SCARB2 | Leukopenia |
| HP:0001399 | 0.0323058496858 | 1.0 | GBA1 SCARB2 | Hepatic failure |
| HP:0000502 | 0.033730956987 | 1.0 | GBA1 SCARB2 | Abnormal conjunctiva morphology |
| HP:0000978 | 0.0371758206793 | 1.0 | GBA1 SCARB2 | Bruising susceptibility |
| HPA:0381202 | 0.0376010915058 | 1.0 | GBA1 SCARB2 | placenta; hofbauer cells[>=Medium] |
| HP:0012145 | 0.0397389633075 | 1.0 | GBA1 SCARB2 | Abnormality of multiple cell lineages in the bone marrow |
| KEGG:00511 | 0.0403663802771 | 0.5 | GBA1 | Other glycan degradation |
| HP:0000790 | 0.0423875440233 | 1.0 | GBA1 SCARB2 | Hematuria |
| HP:0012614 | 0.0423875440233 | 1.0 | GBA1 SCARB2 | Abnormal urine cytology |
| HP:0030875 | 0.0423875440233 | 1.0 | GBA1 SCARB2 | Abnormality of pulmonary circulation |
| HP:0000823 | 0.0451215628267 | 1.0 | GBA1 SCARB2 | Delayed puberty |
| HPA:0381201 | 0.047783554467 | 1.0 | GBA1 SCARB2 | placenta; hofbauer cells[>=Low] |
| HP:0007975 | 0.0499436884913 | 0.5 | GBA1 | Hypometric horizontal saccades |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GBA1 | SCARB2 | 0.981 | 0.364 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| GBA1 | huMAP3_03347.1 huMAP3_08802.1 huMAP3_09327.1 |
| SCARB2 | huMAP3_03347.1 huMAP3_05184.1 huMAP3_07165.1 huMAP3_08042.1 huMAP3_13304.1 |