hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03350.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BCL2L11 | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | 5 | UniProt NCBI |
| BBC3 | Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis) | 5 | UniProt NCBI |
| BAX | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | 5 | UniProt NCBI |
| BAK1 | Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 5.57992231338e-10 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Apoptosis - multiple species |
| GO:1903896 | 1.84188417064e-09 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of IRE1-mediated unfolded protein response |
| GO:1900103 | 1.30247523495e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of endoplasmic reticulum unfolded protein response |
| WP:WP4216 | 1.83346412872e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Chromosomal and microsatellite instability in colorectal cancer |
| REAC:R-HSA-109606 | 2.59981278465e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Intrinsic Pathway for Apoptosis |
| WP:WP254 | 2.60358699721e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Apoptosis |
| GO:1903894 | 2.63389436402e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of IRE1-mediated unfolded protein response |
| KEGG:05210 | 3.35116023993e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Colorectal cancer |
| WP:WP1772 | 3.41209042611e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Apoptosis modulation and signaling |
| GO:0036498 | 8.0516650888e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | IRE1-mediated unfolded protein response |
| WP:WP710 | 9.76659081482e-08 | 1.0 | BBC3 BAK1 BCL2L11 BAX | DNA damage response only ATM dependent |
| GO:0090200 | 1.92476895832e-07 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of release of cytochrome c from mitochondria |
| KEGG:04210 | 1.92988347597e-07 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Apoptosis |
| GO:1905898 | 3.32854782266e-07 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of response to endoplasmic reticulum stress |
| WP:WP4396 | 3.35937426591e-07 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Nonalcoholic fatty liver disease |
| GO:1900101 | 3.93373833587e-07 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of endoplasmic reticulum unfolded protein response |
| WP:WP4864 | 3.98113575652e-07 | 0.75 | BBC3 BCL2L11 BAX | Host pathogen interaction of human coronaviruses apoptosis |
| GO:0090199 | 1.54994552959e-06 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of release of cytochrome c from mitochondria |
| REAC:R-HSA-109581 | 2.92971891971e-06 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Apoptosis |
| GO:0001836 | 3.57196597212e-06 | 1.0 | BBC3 BAK1 BCL2L11 BAX | release of cytochrome c from mitochondria |
| WP:WP3611 | 4.30466180211e-06 | 0.75 | BAK1 BCL2L11 BAX | Photodynamic therapy induced AP 1 survival signaling |
| GO:0070059 | 4.69325242995e-06 | 1.0 | BBC3 BAK1 BCL2L11 BAX | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| REAC:R-HSA-5357801 | 5.49409425626e-06 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Programmed Cell Death |
| GO:0030968 | 1.03937523749e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | endoplasmic reticulum unfolded protein response |
| GO:0010822 | 1.28309598221e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of mitochondrion organization |
| GO:1905897 | 1.37313780553e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of response to endoplasmic reticulum stress |
| KEGG:01524 | 1.8726845031e-05 | 0.75 | BBC3 BAX BAK1 | Platinum drug resistance |
| GO:0034620 | 2.274729582e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | cellular response to unfolded protein |
| GO:0008637 | 3.75329946872e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | apoptotic mitochondrial changes |
| KEGG:05200 | 3.82134789115e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | Pathways in cancer |
| GO:0035967 | 4.16155309515e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | cellular response to topologically incorrect protein |
| GO:0097136 | 6.34131776058e-05 | 0.75 | BAK1 BCL2L11 BAX | Bcl-2 family protein complex |
| GO:2001056 | 6.72337716283e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of cysteine-type endopeptidase activity |
| GO:0006986 | 7.68259096995e-05 | 1.0 | BBC3 BAK1 BCL2L11 BAX | response to unfolded protein |
| REAC:R-HSA-111457 | 0.000102497642323 | 0.5 | BAX BAK1 | Release of apoptotic factors from the mitochondria |
| WP:WP4630 | 0.00010512283989 | 0.75 | BBC3 BAX BAK1 | Measles virus infection |
| KEGG:05162 | 0.000105799991328 | 0.75 | BBC3 BAX BAK1 | Measles |
| GO:0010950 | 0.000120988792772 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of endopeptidase activity |
| GO:0035966 | 0.000130712993938 | 1.0 | BBC3 BAK1 BCL2L11 BAX | response to topologically incorrect protein |
| GO:0010952 | 0.000163423014924 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of peptidase activity |
| GO:0010821 | 0.000175580923958 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of mitochondrion organization |
| KEGG:05169 | 0.000325152133201 | 0.75 | BAK1 BCL2L11 BAX | Epstein-Barr virus infection |
| REAC:R-HSA-111453 | 0.000368856835097 | 0.5 | BBC3 BCL2L11 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| GO:2000116 | 0.000369531169251 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of cysteine-type endopeptidase activity |
| WP:WP1742 | 0.000436026474737 | 0.5 | BBC3 BAX | TP53 network |
| WP:WP3872 | 0.000436026474737 | 0.5 | BAX BAK1 | Regulation of apoptosis by parathyroid hormone related protein |
| WP:WP3982 | 0.000436026474737 | 0.5 | BBC3 BAX | miRNA regulation of p53 pathway in prostate cancer |
| WP:WP2507 | 0.000436026474737 | 0.5 | BAX BAK1 | Nanomaterial induced apoptosis |
| GO:0032469 | 0.000437924933217 | 0.75 | BBC3 BAX BAK1 | endoplasmic reticulum calcium ion homeostasis |
| GO:0031334 | 0.000464844728187 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of protein-containing complex assembly |
| WP:WP4925 | 0.000588856887782 | 0.5 | BBC3 BCL2L11 | Unfolded protein response |
| GO:0005741 | 0.000657606458249 | 1.0 | BBC3 BAK1 BCL2L11 BAX | mitochondrial outer membrane |
| GO:0034976 | 0.000709501150068 | 1.0 | BBC3 BAK1 BCL2L11 BAX | response to endoplasmic reticulum stress |
| WP:WP3613 | 0.000764539714508 | 0.5 | BBC3 BCL2L11 | Photodynamic therapy induced unfolded protein response |
| WP:WP4838 | 0.000828175715845 | 0.5 | BAX BAK1 | Regucalcin in proximal tubule epithelial kidney cells |
| GO:0052548 | 0.000948358662764 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of endopeptidase activity |
| GO:0031968 | 0.00097067298424 | 1.0 | BBC3 BAK1 BCL2L11 BAX | organelle outer membrane |
| GO:0019867 | 0.000993378785041 | 1.0 | BBC3 BAK1 BCL2L11 BAX | outer membrane |
| REAC:R-HSA-9614657 | 0.00122873738811 | 0.5 | BBC3 BCL2L11 | FOXO-mediated transcription of cell death genes |
| REAC:R-HSA-111471 | 0.0013924419067 | 0.5 | BAX BAK1 | Apoptotic factor-mediated response |
| KEGG:05216 | 0.0014030052018 | 0.5 | BAX BAK1 | Thyroid cancer |
| WP:WP3614 | 0.00142851438729 | 0.5 | BAX BAK1 | Photodynamic therapy induced HIF 1 survival signaling |
| GO:0052547 | 0.00147434302567 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of peptidase activity |
| REAC:R-HSA-6803204 | 0.00175047124894 | 0.5 | BBC3 BAX | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| WP:WP1971 | 0.00198508114189 | 0.5 | BBC3 BAX | Integrated cancer pathway |
| GO:0097193 | 0.00219366470745 | 1.0 | BBC3 BAK1 BCL2L11 BAX | intrinsic apoptotic signaling pathway |
| REAC:R-HSA-5620971 | 0.00258893271292 | 0.5 | BAX BAK1 | Pyroptosis |
| GO:0097145 | 0.0028092043205 | 0.5 | BAX BAK1 | BAK complex |
| WP:WP5087 | 0.0029183957539 | 0.75 | BBC3 BAX BAK1 | Pleural mesothelioma |
| KEGG:05213 | 0.00331074310373 | 0.5 | BAX BAK1 | Endometrial cancer |
| WP:WP3959 | 0.00337093843289 | 0.5 | BAX BAK1 | DNA IR double strand breaks and cellular response via ATM |
| GO:2001233 | 0.00342971633668 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of apoptotic signaling pathway |
| KEGG:05217 | 0.00370671577133 | 0.5 | BAX BAK1 | Basal cell carcinoma |
| GO:0045862 | 0.00398236447266 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of proteolysis |
| WP:WP4155 | 0.00405547408869 | 0.5 | BAX BAK1 | Endometrial cancer |
| GO:2001244 | 0.00409056451107 | 0.75 | BBC3 BCL2L11 BAX | positive regulation of intrinsic apoptotic signaling pathway |
| REAC:R-HSA-114452 | 0.00444848198459 | 0.5 | BBC3 BCL2L11 | Activation of BH3-only proteins |
| WP:WP4685 | 0.00449637847065 | 0.5 | BAX BAK1 | Melanoma |
| KEGG:05218 | 0.00471711368352 | 0.5 | BAX BAK1 | Melanoma |
| KEGG:04115 | 0.00502800723414 | 0.5 | BBC3 BAX | p53 signaling pathway |
| WP:WP1530 | 0.00528146385782 | 0.5 | BBC3 BAX | miRNA regulation of DNA damage response |
| WP:WP707 | 0.00528146385782 | 0.5 | BBC3 BAX | DNA damage response |
| WP:WP4255 | 0.00561306746582 | 0.5 | BAX BAK1 | Non small cell lung cancer |
| KEGG:05214 | 0.0056793701001 | 0.5 | BAX BAK1 | Glioma |
| KEGG:05223 | 0.0056793701001 | 0.5 | BAX BAK1 | Non-small cell lung cancer |
| KEGG:05212 | 0.00637013094617 | 0.5 | BAX BAK1 | Pancreatic cancer |
| KEGG:01521 | 0.00673027197618 | 0.5 | BCL2L11 BAX | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.00673027197618 | 0.5 | BAX BAK1 | Chronic myeloid leukemia |
| REAC:R-HSA-5633008 | 0.00718390333861 | 0.5 | BBC3 BAX | TP53 Regulates Transcription of Cell Death Genes |
| GO:0043254 | 0.00749016343662 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of protein-containing complex assembly |
| WP:WP4806 | 0.00781315318354 | 0.5 | BCL2L11 BAX | EGFR tyrosine kinase inhibitor resistance |
| GO:0006919 | 0.0079870728422 | 0.75 | BBC3 BCL2L11 BAX | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0051345 | 0.00813528649859 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of hydrolase activity |
| WP:WP4263 | 0.00821485966847 | 0.5 | BAX BAK1 | Pancreatic adenocarcinoma pathway |
| WP:WP4963 | 0.00821485966847 | 0.5 | BBC3 BAX | p53 transcriptional gene network |
| KEGG:05222 | 0.00909742323246 | 0.5 | BAX BAK1 | Small cell lung cancer |
| WP:WP4658 | 0.00992155513194 | 0.5 | BAX BAK1 | Small cell lung cancer |
| WP:WP5090 | 0.00992155513194 | 0.5 | BAX BAK1 | Complement system in neuronal development and plasticity |
| GO:0043065 | 0.0100596833963 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of apoptotic process |
| GO:0043068 | 0.0120071462095 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of programmed cell death |
| WP:WP5322 | 0.0122792151382 | 0.5 | BCL2L11 BAX | CKAP4 signaling pathway map |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | BAX BAK1 | Regulated Necrosis |
| GO:0010248 | 0.0168521501606 | 0.5 | BAX BAK1 | establishment or maintenance of transmembrane electrochemical gradient |
| REAC:R-HSA-9614085 | 0.0180511544442 | 0.5 | BBC3 BCL2L11 | FOXO-mediated transcription |
| GO:0044089 | 0.0181092817595 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of cellular component biogenesis |
| KEGG:05224 | 0.0198400959038 | 0.5 | BAX BAK1 | Breast cancer |
| GO:0008630 | 0.0209740664347 | 0.75 | BAK1 BCL2L11 BAX | intrinsic apoptotic signaling pathway in response to DNA damage |
| KEGG:05226 | 0.0211069184789 | 0.5 | BAX BAK1 | Gastric cancer |
| KEGG:05160 | 0.0211069184789 | 0.5 | BAX BAK1 | Hepatitis C |
| WP:WP4262 | 0.0221503925292 | 0.5 | BAX BAK1 | Breast cancer pathway |
| KEGG:04932 | 0.0237566589162 | 0.5 | BCL2L11 BAX | Non-alcoholic fatty liver disease |
| GO:0007005 | 0.0242127020237 | 1.0 | BBC3 BAK1 BCL2L11 BAX | mitochondrion organization |
| WP:WP5381 | 0.0245369062383 | 0.5 | BCL2L11 BAX | Smith Magenis and Potocki Lupski syndrome copy number variation |
| CORUM:3492 | 0.0249718442456 | 0.25 | BAX | BAX homo-oligomer complex |
| CORUM:2000 | 0.0249718442456 | 0.25 | BAX | BAX homo-oligomer complex |
| KEGG:05164 | 0.0254912281659 | 0.5 | BAX BAK1 | Influenza A |
| GO:0097190 | 0.0254935353828 | 1.0 | BBC3 BAK1 BCL2L11 BAX | apoptotic signaling pathway |
| GO:0010638 | 0.0254935353828 | 1.0 | BBC3 BAK1 BCL2L11 BAX | positive regulation of organelle organization |
| GO:0080135 | 0.0265542529269 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of cellular response to stress |
| KEGG:05206 | 0.0269222811984 | 0.5 | BCL2L11 BAK1 | MicroRNAs in cancer |
| GO:2001235 | 0.0291371139957 | 0.75 | BBC3 BCL2L11 BAX | positive regulation of apoptotic signaling pathway |
| GO:0043280 | 0.0291371139957 | 0.75 | BBC3 BCL2L11 BAX | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| KEGG:05202 | 0.0295193078423 | 0.5 | BAX BAK1 | Transcriptional misregulation in cancer |
| KEGG:04141 | 0.0298999303213 | 0.5 | BAX BAK1 | Protein processing in endoplasmic reticulum |
| KEGG:05225 | 0.0310562109 | 0.5 | BAX BAK1 | Hepatocellular carcinoma |
| KEGG:05130 | 0.0334335704012 | 0.5 | BAX BAK1 | Pathogenic Escherichia coli infection |
| KEGG:05167 | 0.0346546128597 | 0.5 | BAX BAK1 | Kaposi sarcoma-associated herpesvirus infection |
| GO:0030162 | 0.0349344415021 | 1.0 | BBC3 BAK1 BCL2L11 BAX | regulation of proteolysis |
| MIRNA:hsa-miR-504-5p | 0.0405772675542 | 0.75 | BBC3 BCL2L11 BAX | hsa-miR-504-5p |
| KEGG:05203 | 0.0424327978034 | 0.5 | BAX BAK1 | Viral carcinogenesis |
| KEGG:05163 | 0.0451972531521 | 0.5 | BAX BAK1 | Human cytomegalovirus infection |
| KEGG:05170 | 0.0456663239038 | 0.5 | BAX BAK1 | Human immunodeficiency virus 1 infection |
| CORUM:5823 | 0.049938562206 | 0.25 | BAK1 | MCL1-BAK1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BCL2L11 | BAX | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BAX | BAK1 | 0.987 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BBC3 | BAX | 0.966 | bioplex_WMM bioplex3_WMM WMM_only | |
| BBC3 | BAK1 | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | |
| BCL2L11 | BBC3 | 0.956 | bioplex_WMM bioplex3_WMM WMM_only | |
| BCL2L11 | BAK1 | 0.947 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes