hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_03360.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CD8B | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) | 5 | UniProt NCBI |
| FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) | 5 | UniProt NCBI |
| PRSS3 | Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV) | 5 | UniProt NCBI |
| PRSS1 | Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2] | 5 | UniProt NCBI |
| PRSS2 | Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04974 | 2.73701816965e-06 | 1.0 | PRSS1 PRSS3 PRSS2 | Protein digestion and absorption |
| KEGG:04972 | 3.11554307054e-06 | 1.0 | PRSS1 PRSS3 PRSS2 | Pancreatic secretion |
| KEGG:05164 | 2.54584376622e-05 | 1.0 | PRSS1 PRSS3 PRSS2 | Influenza A |
| HP:0005206 | 3.79604886547e-05 | 0.666666666667 | PRSS1 PRSS2 | Pancreatic pseudocyst |
| HPA:0481353 | 5.42879636956e-05 | 1.0 | PRSS1 PRSS3 PRSS2 | small intestine; paneth cells[High] |
| KEGG:04080 | 5.60236181806e-05 | 1.0 | PRSS1 PRSS3 PRSS2 | Neuroactive ligand-receptor interaction |
| HPA:0151353 | 6.45227621189e-05 | 1.0 | PRSS1 PRSS3 PRSS2 | duodenum; paneth cells[High] |
| HP:0005213 | 7.59175135241e-05 | 0.666666666667 | PRSS1 PRSS2 | Pancreatic calcification |
| REAC:R-HSA-9758881 | 0.000143154936711 | 0.666666666667 | PRSS1 PRSS3 | Uptake of dietary cobalamins into enterocytes |
| HPA:0481352 | 0.000158630372583 | 1.0 | PRSS1 PRSS3 PRSS2 | small intestine; paneth cells[>=Medium] |
| REAC:R-HSA-1462054 | 0.000190864539041 | 0.666666666667 | PRSS3 PRSS2 | Alpha-defensins |
| HPA:0151352 | 0.000216250894893 | 1.0 | PRSS1 PRSS3 PRSS2 | duodenum; paneth cells[>=Medium] |
| HPA:0481351 | 0.000241421635567 | 1.0 | PRSS1 PRSS3 PRSS2 | small intestine; paneth cells[>=Low] |
| TF:M03886_1 | 0.000249912106799 | 1.0 | PRSS1 PRSS3 PRSS2 | Factor: Sox-2; motif: NNCCWTTGTTNTKN; match class: 1 |
| HPA:0151351 | 0.000282725979499 | 1.0 | PRSS1 PRSS3 PRSS2 | duodenum; paneth cells[>=Low] |
| REAC:R-HSA-196741 | 0.000817692256233 | 0.666666666667 | PRSS1 PRSS3 | Cobalamin (Cbl, vitamin B12) transport and metabolism |
| HP:0100027 | 0.00132788970801 | 0.666666666667 | PRSS1 PRSS2 | Recurrent pancreatitis |
| REAC:R-HSA-1461973 | 0.00157362645287 | 0.666666666667 | PRSS3 PRSS2 | Defensins |
| REAC:R-HSA-1592389 | 0.00188000535098 | 0.666666666667 | PRSS1 PRSS2 | Activation of Matrix Metalloproteinases |
| HP:0030247 | 0.00193466002352 | 0.666666666667 | PRSS1 PRSS2 | Splanchnic vein thrombosis |
| REAC:R-HSA-6803157 | 0.0108549519561 | 0.666666666667 | PRSS3 PRSS2 | Antimicrobial peptides |
| HP:0011227 | 0.0114052550978 | 0.666666666667 | PRSS1 PRSS2 | Elevated circulating C-reactive protein concentration |
| GO:0004252 | 0.0120707547584 | 1.0 | PRSS1 PRSS3 PRSS2 | serine-type endopeptidase activity |
| TF:M13133 | 0.0124731132503 | 1.0 | PRSS1 PRSS3 PRSS2 | Factor: GABPBETA; motif: NGMTGATGCAAYN |
| HP:0032436 | 0.0125029572242 | 0.666666666667 | PRSS1 PRSS2 | Abnormal circulating C-reactive protein concentration |
| HP:0002570 | 0.0142438401108 | 0.666666666667 | PRSS1 PRSS2 | Steatorrhea |
| HP:0002630 | 0.0154672949612 | 0.666666666667 | PRSS1 PRSS2 | Fat malabsorption |
| GO:0008236 | 0.0219076797621 | 1.0 | PRSS1 PRSS3 PRSS2 | serine-type peptidase activity |
| HP:0001738 | 0.022338444757 | 0.666666666667 | PRSS1 PRSS2 | Exocrine pancreatic insufficiency |
| HP:0012092 | 0.023094623718 | 0.666666666667 | PRSS1 PRSS2 | Abnormality of exocrine pancreas physiology |
| GO:0017171 | 0.0231134095574 | 1.0 | PRSS1 PRSS3 PRSS2 | serine hydrolase activity |
| HP:0004936 | 0.0254384546332 | 0.666666666667 | PRSS1 PRSS2 | Venous thrombosis |
| HP:0001733 | 0.0313463863633 | 0.666666666667 | PRSS1 PRSS2 | Pancreatitis |
| HP:0002202 | 0.0331471884053 | 0.666666666667 | PRSS1 PRSS2 | Pleural effusion |
| REAC:R-HSA-196849 | 0.0336004634561 | 0.666666666667 | PRSS1 PRSS3 | Metabolism of water-soluble vitamins and cofactors |
| REAC:R-HSA-1474228 | 0.037053837229 | 0.666666666667 | PRSS1 PRSS2 | Degradation of the extracellular matrix |
| HP:0012090 | 0.0439470786184 | 0.666666666667 | PRSS1 PRSS2 | Abnormal pancreas morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRSS3 | PRSS2 | 0.997 | 0.44 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| FCER1A | PRSS2 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CD8B | PRSS2 | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PRSS1 | PRSS2 | 0.953 | 0.372 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PRSS3 | PRSS1 | 0.343 | 0.278 | bioplex3_WMM WMM_only boldt_WMM |
Related Complexes